Primary Castleman's disease in the liver: A case report and literature review

Lv,Kun; Zhang,Chun‑Li; Xu,Mao‑Sheng

doi:10.3892/mco.2018.1576

Primary Castleman's disease in the liver: A case report and literature review

Authors:
- Kun Lv
- Chun‑Li Zhang
- Mao‑Sheng Xu
View Affiliations

Affiliations: The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Pathology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
Published online on: February 15, 2018 https://doi.org/10.3892/mco.2018.1576
Pages: 575-578

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Castleman's disease (CD) is a lymphoproliferative abnormality, also referred to as giant lymph node hyperplasia or follicular lymphoid hyperplasia. The occurrence of CD in the liver is rare. Radiological diagnosis of hepatic CD by computed tomography (CT) and magnetic resonance imaging (MRI) remains difficult. On imaging, hepatic CD is often expressed as a single, well‑defined soft tissue lesion, with rare cystic degeneration and focal necrosis. The CD lesions appear as hypervascular with abundant cell proliferation on CT and MRI. Polymorphic calcification is commonly identified in the lesion. However, these findings are non‑specific for a definitive radiological diagnosis. We herein present a case of hepatic CD and review its pathological and imaging characteristics. In particular, a strip‑like area was observed extending from the nodule, which may be helpful for the diagnosis of CD in the liver.

View Figures

View References

1	Travis WD, Linnoila RI, Tsokos MG, et al: Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol. 15:529–553. 1991. View Article : Google Scholar : PubMed/NCBI
2	Lukina O, Gorbunkov S, Dvorakovskaja I, Varlamov V and Akopov A: Fast-growing large cell neuroendocrine carcinoma of mediastinum. Ann Thorac Surg. 91:1618–1620. 2011. View Article : Google Scholar : PubMed/NCBI
3	Faggiano A, Sabourin JC, Ducreux M, et al: Pulmonary and extrapulmonary poorly differentiated large cell neuroendocrine carcinomas: diagnostic and prognostic features. Cancer. 110:265–274. 2007. View Article : Google Scholar : PubMed/NCBI
4	Erhan Y, Dikmen Y, Yucebilgin MS, Zekioglu O, Mgoyi L and Terek MC: Large cell neuroendocrine carcinoma of the uterine corpus metastatic to brain and lung: case report and review of the literature. Eur J Gynaecol Oncol. 25:109–112. 2004.PubMed/NCBI
5	Nguyen ML, Han L, Minors AM, et al: Rare large cell neuroendocrine tumor of the endometrium: A case report and review of the literature. Int J Surg Case Rep. 4:651–655. 2013. View Article : Google Scholar : PubMed/NCBI
6	Kobayashi A, Yahata T, Nanjo S, et al: Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature. Mol Clin Oncol. 6:881–885. 2017. View Article : Google Scholar : PubMed/NCBI
7	Froio E, D' Adda T, Fellegara G, et al: Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis. Lung Cancer. 64:371–377. 2009. View Article : Google Scholar : PubMed/NCBI
8	Ono K, Yokota NR, Yoshioka E, et al: Metastatic large cell neuroendocrine carcinoma of the lung arising from the uterus: A pitfall in lung cancer diagnosis. Pathol Res Pract. 212:654–657. 2016. View Article : Google Scholar : PubMed/NCBI
9	Gilks CB, Young RH, Gersell DJ and Clement PB: Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol. 21:905–914. 1997. View Article : Google Scholar : PubMed/NCBI
10	Wang KL, Yang YC, Wang TY, et al: Neuroendocrine carcinoma of the uterine cervix: A clinicopathologic retrospective study of 31 cases with prognostic implications. J Chemother. 18:209–216. 2006. View Article : Google Scholar : PubMed/NCBI
11	Kurman RJ, Ronnett B.M..Sherman M.E..Wilkinson E.J.: Tumor of the cervix. ARP press; Silver Spring, Maryland: 2010
12	Mulvany NJ and Allen DG: Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. Int J Gynecol Pathol. 27:49–57. 2008. View Article : Google Scholar : PubMed/NCBI
13	Posligua L, Malpica A, Liu J, Brown J and Deavers MT: Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread. Arch Pathol Lab Med. 132:1821–1824. 2008.PubMed/NCBI
14	Makihara N, Maeda T, Nishimura M, et al: Large cell neuroendocrine carcinoma originating from the uterine endometrium: a report on magnetic resonance features of 2 cases with very rare and aggressive tumor. Rare Tumors. 4:e372012. View Article : Google Scholar : PubMed/NCBI
15	McCluggage WG, Oliva E, Connolly LE, McBride HA and Young RH: An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. Int J Gynecol Pathol. 23:330–336. 2004. View Article : Google Scholar : PubMed/NCBI