Squamous cell carcinoma of the breast as a clinical diagnostic challenge

Jakubowska,Katarzyna; Kańczuga‑Koda,Luiza; Kisielewski,Wojciech; Koda,Mariusz; Famulski,Waldemar

doi:10.3892/mco.2018.1581

April-2018 Volume 8 Issue 4

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April-2018 Volume 8 Issue 4

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Article

Squamous cell carcinoma of the breast as a clinical diagnostic challenge

Authors:
- Katarzyna Jakubowska
- Luiza Kańczuga‑Koda
- Wojciech Kisielewski
- Mariusz Koda
- Waldemar Famulski
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Affiliations: Department of Pathomorphology, Comprehensive Cancer Center, 15‑027 Białystok, Poland, Department of Medical Pathomorphology, Medical University of Białystok, 15‑269 Białystok, Poland, Department of General Pathomorphology, Medical University of Białystok, 15‑269 Białystok, Poland
Pages: 582-586
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Published online on: February 22, 2018

https://doi.org/10.3892/mco.2018.1581
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Abstract

Squamous cell carcinoma (SqCC) of the breast should be differentiated between the primary skin keratinizing squamous carcinoma and squamous metaplastic cancer. In the current study, the cases of two patients who were diagnosed with SqCC originated from skin and the breast were discussed. A fine‑needle aspiration biopsy confirmed the presence of atypical squamous cells. In both cases, the microscopic examination of the surgical specimen revealed a malignant neoplasm differentiated into SqCC characterized by keratinizing cancer cells with abundant eosiphilic cytoplasm with large, hyperchromatic vesicular nuclei. Immunohistochemical studies showed negative for progesterone and estrogen receptors and human epidermal growth factor receptor 2. Moreover, negative expression of cytokeratin 7 and 20 was confirmed. The diagnosis of the both tumors was established based on the detailed analysis of clinical, macroscopical and microscopical information. SqCC localized in the breast is a great diagnostic challenge in pathomorphology and more attention should be paid for analysis of such lesions in daily practice.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Squamous cell carcinoma of the breast as a clinical diagnostic challenge

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Abstract

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