Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

Ogura,Jumpei; Adachi,Yasushi; Yasumoto,Koji; Okamura,Akiharu; Nonogaki,Hirofumi; Kakui,Kazuyo; Yamanoi,Koji; Suginami,Koh; Koyama,Takashi; Ikehara,Susumu

doi:10.3892/mco.2018.1583

April-2018 Volume 8 Issue 4

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April-2018 Volume 8 Issue 4

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Case Report

Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

Authors:
- Jumpei Ogura
- Yasushi Adachi
- Koji Yasumoto
- Akiharu Okamura
- Hirofumi Nonogaki
- Kazuyo Kakui
- Koji Yamanoi
- Koh Suginami
- Takashi Koyama
- Susumu Ikehara
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Affiliations: Department of Obstetrics and Gynecology, Toyooka Hospital, Toyooka, Hyogo 668-8501, Japan, Department of Diagnostic Pathology, Toyooka Hospital, Toyooka, Hyogo 668-8501, Japan, Department of Diagnostic Pathology, Kakogawa Central City Hospital, Kakogawa, Hyogo 675-8611, Japan, Department of Radiology, Toyooka Hospital, Toyooka, Hyogo 668‑8501, Japan, Professor Emeritus, Kansai Medical University, Hirakata, Osaka 573-1010, Japan
Pages: 571-574
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Published online on: February 26, 2018

https://doi.org/10.3892/mco.2018.1583
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Abstract

Large-cell neuroendocrine carcinoma (LCNEC) of the endometrium is an extremely rare, high-grade malignant tumor. We herein report a case of a rapidly growing LCNEC arising in the endometrium. A 52-year-old woman was referred to Toyooka Hospital (Tooyoka, Japan) due to genital bleeding in February 2016. There had been no abnormalities on a regular gynecological and physical examination 3 months prior to the consultation. Imaging (computed tomography and magnetic resonance imaging) and a pelvic examination revealed a tumor sized 16.9x8.4x7.8 mm occupying the intrauterine cavity and extending into the vaginal cavity. Multiple metastatic pelvic and paraaortic lymph nodes were also identified. Continuous bleeding from the tumor was observed, and a blood examination revealed anemia, which was likely due to that bleeding. Biopsy of the tumor was performed, and large atypical cells were identified. The tumor cells were negative for cytokeratin AE1/AE3 and chromogranin A, but positive for CD56 and synaptophysin. There was also an abundance of Ki-67-positive cells in the tumor, altogether suggesting that the tumor was an LCNEC. The patient succumbed to the disease 36 days after the first consultation. Based on the findings of the present case and previously published cases, LCNECs arising in the endometrium may progress rapidly and are associated with an unfavourable outcome. LCNEC should be included in the differential diagnosis in cases of rapidly growing tumors of the uterine corpus.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

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