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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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May-2018 Volume 8 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report

  • Authors:
    • Noriyuki Horiguchi
    • Tomomitsu Tahara
    • Tomohiko Kawamura
    • Masaaki Okubo
    • Takamitsu Ishizuka
    • Naoko Nakano
    • Yoshihito Nakagawa
    • Mitsuo Nagasaka
    • Mitsuru Nakagawa
    • Tetsuya Tsukamoto
    • Tomoyuki Shibata
    • Naoki Ohmiya

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, School of Medicine, Fujita Health University, Toyoake, Aichi 470‑1192, Japan, Department of Diagnostic Pathology I, School of Medicine, Fujita Health University, Toyoake, Aichi 470‑1192, Japan
  • Pages: 657-660
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/mco.2018.1586
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Abstract

Epstein-Barr virus (EBV) infection is involved in a subset of gastric carcinoma (GC) cases, and is associated with distinct clinicopathological features. The present study reports a unique case of EBV‑associated early‑stage GC compared with the other cases experienced in our hospital. A 72‑year‑old male receiving treatment for cerebral infarction underwent an esophagogastroduodenoscopy (EGD) for suspicion of gastrointestinal bleeding. EGD revealed a type 0‑I protruding lesion in the lesser curvature of the upper gastric corpus. Biopsy indicated well‑differentiated adenocarcinoma. As the tumor diameter was >3 cm and the thickness of the tumor suggested submucosal invasion, laparoscopic gastrectomy was performed. Histological assessment revealed polypoid growth of an intramucosal, differentiated, tubular or papillary adenocarcinoma, with dense infiltration of lymphocytes. The carcinoma crypts were found to be EBV‑positive on in situ hybridization. A review of the clinicopathological features of 25 EBV‑associated GCs from 20 patients treated in our hospital between 2005 and 2014 was performed. All of these tumors, except that in the current case, appeared as shallow, depressed or ulcerative lesions. Thus, the current case appears to represent an unusual growth of EBV-positive GC.
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Copy and paste a formatted citation
Spandidos Publications style
Horiguchi N, Tahara T, Kawamura T, Okubo M, Ishizuka T, Nakano N, Nakagawa Y, Nagasaka M, Nakagawa M, Tsukamoto T, Tsukamoto T, et al: Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report. Mol Clin Oncol 8: 657-660, 2018.
APA
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N. ... Ohmiya, N. (2018). Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report. Molecular and Clinical Oncology, 8, 657-660. https://doi.org/10.3892/mco.2018.1586
MLA
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N., Nakagawa, Y., Nagasaka, M., Nakagawa, M., Tsukamoto, T., Shibata, T., Ohmiya, N."Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report". Molecular and Clinical Oncology 8.5 (2018): 657-660.
Chicago
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N., Nakagawa, Y., Nagasaka, M., Nakagawa, M., Tsukamoto, T., Shibata, T., Ohmiya, N."Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report". Molecular and Clinical Oncology 8, no. 5 (2018): 657-660. https://doi.org/10.3892/mco.2018.1586
Copy and paste a formatted citation
x
Spandidos Publications style
Horiguchi N, Tahara T, Kawamura T, Okubo M, Ishizuka T, Nakano N, Nakagawa Y, Nagasaka M, Nakagawa M, Tsukamoto T, Tsukamoto T, et al: Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report. Mol Clin Oncol 8: 657-660, 2018.
APA
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N. ... Ohmiya, N. (2018). Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report. Molecular and Clinical Oncology, 8, 657-660. https://doi.org/10.3892/mco.2018.1586
MLA
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N., Nakagawa, Y., Nagasaka, M., Nakagawa, M., Tsukamoto, T., Shibata, T., Ohmiya, N."Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report". Molecular and Clinical Oncology 8.5 (2018): 657-660.
Chicago
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N., Nakagawa, Y., Nagasaka, M., Nakagawa, M., Tsukamoto, T., Shibata, T., Ohmiya, N."Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report". Molecular and Clinical Oncology 8, no. 5 (2018): 657-660. https://doi.org/10.3892/mco.2018.1586
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