Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2018 Volume 9 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 9 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer

  • Authors:
    • Yajuan Lv
    • Jiandong Zhang
    • Zhen Liu
    • Ning Liang
    • Yuan Tian
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 70-74
    |
    Published online on: May 10, 2018
       https://doi.org/10.3892/mco.2018.1622
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the efficacy and life quality of temozolomide (TMZ) combined with whole-brain radiotherapy (WBRT) for patients with brain metastases (BM) from non-small-cell lung cancer (NSCLC). A total of 77 cases of patients with lung cancer and BM were selected and divided into two groups; the first group was administered WBRT with TMZ, and the second group was administered WBRT with placebo. The efficacy, overall survival (OS) and quality of life (QoL) were then compared between the two groups. There were no significant differences in toxicity between the two groups. However, the first group exhibited an advantage over the second group in terms of objective response and OS (P<0.5). Therefore, WBRT may improve the QoL of patients with BM. TMZ concomitantly with WBRT was well-tolerated and may be recommended for the treatment of BM from NSCLC.
View Figures

Figure 1

Figure 2

View References

1 

Seoane J and De Mattos-Arruda L: Brain metastasis: New opportunities to tackle therapeutic resistance. Mol Oncol. 8:1120–1131. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Berger LA, Riesenberg H, Bokemeyer C and Atanackovic D: CNS metastases in non-small-cell lung cancer: Current role of EGFR-TKI therapy and future perspectives. Lung Cancer. 80:242–248. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, Sneed PK, Chao ST, Weil RJ, Suh J, et al: Summary report on the graded prognostic assessment: An accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol. 30:419–425. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Tabouret E, Chinot O, Metellus P, Tallet A, Viens P and Gonçalves A: Recent trends in epidemiology of brain metastases: An overview. Anticancer Res. 32:4655–4662. 2012.PubMed/NCBI

5 

Baykara M, Kurt G, Buyukberber S, Demirci U, Ceviker N, Algin E, Coskun U, Aykol S, Emmez H, Ozet A, et al: Management of brain metastases from non-small cell lung cancer. J Cancer Res Ther. 10:915–921. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Scoccianti S and Ricardi U: Treatment of brain metastases: Review of phase III randomized controlled trials. Radiother Oncol. 102:168–179. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Walbert T and Gilbert MR: The role of chemotherapy in the treatment of patients with brain metastases from solid tumors. Int J Clin Oncol. 14:299–306. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Sperduto PW, Wang M, Robins HI, Schell MC, Werner-Wasik M, Komaki R, Souhami L, Buyyounouski MK, Khuntia D, Demas W, et al: A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320. Int J Radiat Oncol Biol Phys. 85:1312–1318. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Chun SG, Choe KS, Iyengar P, Yordy JS and Timmerman RD: Isolated central nervous system progression on Crizotinib: An Achilles heel of non-small cell lung cancer with EML4-ALK translocation? Cancer Biol Ther. 13:1376–1383. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Tatar Z, Thivat E, Planchat E, Gimbergues P, Gadea E, Abrial C and Durando X: Temozolomide and unusual indications: Review of literature. Cancer Treat Rev. 39:125–135. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Chua D, Krzakowski M, Chouaid C, Pallotta MG, Martinez JI, Gottfried M, Curran W and Throuvalas N: Whole-brain radiation therapy plus concomitant temozolomide for the treatment of brain metastases from non-small-cell lung cancer: A randomized, open-label phase II study. Clin Lung Cancer. 11:176–181. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Gamboa-Vignolle C, Ferrari-Carballo T, Arrieta Ó and Mohar A: Whole-brain irradiation with concomitant daily fixed-dose temozolomide for brain metastases treatment: A randomised phase II trial. Radiother Oncol. 102:187–191. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Christodoulou C, Bafaloukos D, Linardou H, Aravantinos G, Bamias A, Carina M, Klouvas G and Skarlos D: Hellenic Cooperative Oncology Group: Temozolomide (TMZ) combined with cisplatin (CDDP) in patients with brain metastases from solid tumors: A Hellenic Cooperative Oncology Group (HeCOG) Phase II study. J Neurooncol. 71:61–65. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Trotti A, Colevas AD, Setser A, Rusch V, Jaques D, Budach V, Langer C, Murphy B, Cumberlin R and Coleman CN: CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 13:176–181. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Ferrarese F, Baggio V, Zorat PL and Fiore D: Treatment and prophylaxis for brain metastases from non-small cell lung cancer: whole brain radiation treatment versus stereotactic radiosurgery. Ann Oncol Suppl. 2:ii71–ii72. 2006. View Article : Google Scholar

16 

Larson D and Sahgal A, Larson D and Sahgal A: Adjuvant whole brain radiotherapy: strong emotions decide but rationale studies are needed: in regard to Brown et al. (Int J Radiat Oncol Biol Phys 2008;70:1305-1309). In reply to Drs. Larson and Sahgal. Int J Radiat Oncol Biol Phys. 75:316–317. 2009.

17 

Liu R, Wang X, Ma B, Yang K, Zhang Q and Tian J: Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: A meta-analysis. Anticancer Drugs. 21:120–128. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Zhao Q, Qin Q, Sun J, Han D, Wang Z, Teng J and Li B: Brain radiotherapy plus concurrent temolomide versus radiotherapy alone for patients with brain metastases: A meta-analysis. PLoS One. 11:e01504192016. View Article : Google Scholar : PubMed/NCBI

19 

Antonadou D, Paraskevaidis M, Sarris G, Coliarakis N, Economou I, Karageorgis P and Throuvalas N: Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J Clin Oncol. 20:3644–3650. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Xia Deng, Zhen Zheng, Baochai Lin, et al: The efficacy and roles of combining temozolomide with whole brain radiotherapy in protection neurocognitive function and improvement quality of life of non-small-cell lung cancer patients with brain metastases. BMC cancer. 17:422017. View Article : Google Scholar : PubMed/NCBI

21 

Addeo R, Caraglia M, Faiola V, Capasso E, Vincenzi B, Montella L, Guarrasi R, Caserta L and Del Prete S: Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life. BMC Cancer. 7:182007. View Article : Google Scholar : PubMed/NCBI

22 

Ma W, Li N, An Y, Zhou C, Bo C and Zhang G: Effects of Temozolomide and Radiotherapy on Brain Metastatic Tumor: A Systematic Review and Meta-Analysis. World Neurosurg. 92:197–205. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Qin H, Pan F, Li J, Zhang X, Liang H and Ruan Z: Whole brain radiotherapy plus concurrent chemotherapy in non-small cell lung cancer patients with brain metastases: A meta-analysis. PLoS One. 9:e1114752014. View Article : Google Scholar : PubMed/NCBI

24 

Hassler MR, Pfeifer W, Knocke-Abulesz TH, Geissler K, Altorjai G, Dieckmann K and Marosi C: Temozolomide added to whole brain radiotherapy in patients with multiple brain metastases of non-small-cell lung cancer: A multicentric Austrian phase II study. Wien Klin Wochenschr. 125:481–486. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Zheng MH, Sun HT, Xu JG, Yang G, Huo LM, Zhang P, Tian JH and Yang KH: Combining Whole-Brain Radiotherapy with Gefitinib/Erlotinib for Brain Metastases from Non-Small-Cell Lung Cancer: A Meta-Analysis. BioMed Res Int. 2016:58073462016. View Article : Google Scholar : PubMed/NCBI

26 

Broniscer A, Panetta JC, O'Shaughnessy M, Fraga C, Bai F, Krasin MJ, Gajjar A and Stewart CF: Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin Cancer Res. 13:1511–1515. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Chow R, Lao N, Popovic M, Chow E, Cella D, Beaumont J, Lam H, Pulenzas N, Bedard G, Wong E, et al: Comparison of the EORTC QLQ-BN20 and the FACT-Br quality of life questionnaires for patients with primary brain cancers: A literature review. Support Care Cancer. 22:2593–2598. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Pulenzas N, Ray S, Zhang L, McDonald R, Cella D, Rowbottom L, Sahgal A, Soliman H, Tsao M, Danjoux C, et al: The Brain Symptom and Impact Questionnaire in brain metastases patients: A prospective long-term follow-up study. CNS Oncol. 5:31–40. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Pan CJ, Liu HC, Liang SY, Liu CY, Wu WW and Cheng SF: Resilience and coping strategies influencing the quality of life in patients with brain tumor. Clin Nurs Res Jun. 1:10547738177145622017.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lv Y, Zhang J, Liu Z, Liang N and Tian Y: Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer. Mol Clin Oncol 9: 70-74, 2018.
APA
Lv, Y., Zhang, J., Liu, Z., Liang, N., & Tian, Y. (2018). Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer. Molecular and Clinical Oncology, 9, 70-74. https://doi.org/10.3892/mco.2018.1622
MLA
Lv, Y., Zhang, J., Liu, Z., Liang, N., Tian, Y."Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer". Molecular and Clinical Oncology 9.1 (2018): 70-74.
Chicago
Lv, Y., Zhang, J., Liu, Z., Liang, N., Tian, Y."Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer". Molecular and Clinical Oncology 9, no. 1 (2018): 70-74. https://doi.org/10.3892/mco.2018.1622
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Y, Zhang J, Liu Z, Liang N and Tian Y: Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer. Mol Clin Oncol 9: 70-74, 2018.
APA
Lv, Y., Zhang, J., Liu, Z., Liang, N., & Tian, Y. (2018). Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer. Molecular and Clinical Oncology, 9, 70-74. https://doi.org/10.3892/mco.2018.1622
MLA
Lv, Y., Zhang, J., Liu, Z., Liang, N., Tian, Y."Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer". Molecular and Clinical Oncology 9.1 (2018): 70-74.
Chicago
Lv, Y., Zhang, J., Liu, Z., Liang, N., Tian, Y."Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer". Molecular and Clinical Oncology 9, no. 1 (2018): 70-74. https://doi.org/10.3892/mco.2018.1622
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team