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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2018 Volume 9 Issue 2

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Case Report Open Access

Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report

  • Authors:
    • Tamaki Tamanuki
    • Tomoyoshi Aoyagi
    • Akiyuki Murano
    • Hiroshi Matsuzaki
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Funabashi Municipal Medical Center, Funabashi, Chiba 273‑8588, Japan, Department of Oral and Maxillofacial Surgery, Funabashi Municipal Medical Center, Funabashi, Chiba 273‑8588, Japan
    Copyright: © Tamanuki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 215-218
    |
    Published online on: June 14, 2018
       https://doi.org/10.3892/mco.2018.1656
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Abstract

An 83‑year‑old woman underwent mastectomy for breast cancer of the right breast in 2008. In addition to hormone therapy and irradiation, zoledronate was started for bone metastasis 6 months postoperatively. Five years after the operation, the patient developed osteonecrosis of the jaw, and underwent sequestrectomy because of uncontrollable pain in the mandible. The patient visited our hospital for a 1‑week history of fever and right facial swelling with pain, and was diagnosed with right mandibular cellulitis. Despite antibiotic therapy, the patient fell into shock. Follow‑up computed tomography showed gas formation extending down to the posterior mediastinum, which was compatible with descending necrotizing mediastinitis (DNM). The patient succumbed to septicemia on the third hospital day. The mortality rate of DNM greatly increases in patients with advanced cancer because clinicians cannot perform radical treatment due to the impaired general condition and limited life expectancy. DNM advances by the hour; therefore, repeated computed tomography is essential when antibiotic therapy does not improve the patient's condition. Attention must be paid to detect signs of DNM in such patients. To the best of our knowledge, this is the first report in English regarding DNM caused by bisphosphonate‑induced osteonecrosis of the jaw.
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1 

Kohno N, Aogi K, Minami H, Nakamura S, Asaga T, Iino Y, Watanabe T, Goessl C, Ohashi Y and Takashima S: Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial. J Clin Oncol. 23:3314–3321. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Takahashi S, Iwase T, Kohno N, Ishikawa T, Taguchi T, Takahashi M, Horiguchi J, Nakamura S, Hozumi Y, Fukunaga M and Noguchi S: Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results. Breast Cancer Res Treat. 133:685–693. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Mauri D, Valachis A, Polyzos IP, Polyzos NP, Kamposioras K and Pesce LL: Osteonecrosis of the jaw and use of bisphosphonates in adjuvant breast cancer treatment: A meta-analysis. Breast Cancer Res Treat. 116:433–439. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Valachis A, Polyzos NP, Georgoulias V, Mavroudis D and Mauri D: Lack of evidence for fracture prevention in early breast cancer bisphosphonate trials: A meta-analysis. Gynecol Oncol. 117:139–145. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Marx RE, Sawatari Y, Fortin M and Broumand V: Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 63:1567–1575. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Kyrgidis A, Vahtsevanos K, Koloutsos G, Andreadis C, Boukovinas I, Teleioudis Z, Patrikidou A and Triaridis S: Bisphosphonate-related osteonecrosis of the jaws: A case-control study of risk factors in breast cancer patients. J Clin Oncol. 26:4634–4638. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Kim YS and Park WC: Atypical subtrochanteric femur fracture in patient with metastatic breast cancer treated with zoledronic acid. J Breast Cancer. 15:261–264. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Marx RE: Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 61:1115–1117. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, Koutsoukou V, Gika D, Anagnostopoulos A, Papadimitriou C, et al: Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors. J Clin Oncol. 23:8580–8587. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Vahtsevanos K, Kyrgidis A, Verrou E, Katodritou E, Triaridis S, Andreadis CG, Boukovinas I, Koloutsos GE, Teleioudis Z, Kitikidou K, et al: Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol. 27:5356–5362. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE and Mehrotra B: American Association of Oral Maxillofacial Surgeons; American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg. 67 Suppl 1:S2–S12. 2009. View Article : Google Scholar

12 

Qi WX, Tang LN, He AN, Yao Y and Shen Z: Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: A meta-analysis of seven randomized controlled trials. Int J Clin Oncol. 19:403–410. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Papalia E, Rena O, Oliaro A, Cavallo A, Giobbe R, Casadio C, Maggi G and Mancuso M: Descending necrotizing mediastinitis: Surgical management. Eur J Cardiothorac Surg. 20:739–742. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Novakov IP, Safev GP and Peicheva SE: Descending necrotizing mediastinitis of odontogenic origin-personal experience and literature review. Folia Med (Plovdiv). 52:13–20. 2010.PubMed/NCBI

15 

Sancho LM, Minamoto H, Fernandez A, Sennes LU and Jatene FB: Descending necrotizing mediastinitis: A retrospective surgical experience. Eur J Cardiothorac Surg. 16:200–205. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Furst IM, Ersil P and Caminiti M: A rare complication of tooth abscess-Ludwig's angina and mediastinitis. J Can Dent Assoc. 67:324–327. 2001.PubMed/NCBI

17 

Chen KC, Chen JS, Kuo SW, Huang PM, Hsu HH, Lee JM and Lee YC: Descending necrotizing mediastinitis: A 10-year surgical experience in a single institution. J Thorac Cardiovasc Surg. 136:191–198. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Moncada R, Warpeha R, Pickleman J, Spak M, Cardoso M, Berkow A and White H: Mediastinitis from odontogenic and deep cervical infection. Anatomic pathways of propagation. Chest. 73:497–500. 1978.

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Copy and paste a formatted citation
Spandidos Publications style
Tamanuki T, Aoyagi T, Murano A and Matsuzaki H: Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report. Mol Clin Oncol 9: 215-218, 2018.
APA
Tamanuki, T., Aoyagi, T., Murano, A., & Matsuzaki, H. (2018). Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report. Molecular and Clinical Oncology, 9, 215-218. https://doi.org/10.3892/mco.2018.1656
MLA
Tamanuki, T., Aoyagi, T., Murano, A., Matsuzaki, H."Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report". Molecular and Clinical Oncology 9.2 (2018): 215-218.
Chicago
Tamanuki, T., Aoyagi, T., Murano, A., Matsuzaki, H."Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report". Molecular and Clinical Oncology 9, no. 2 (2018): 215-218. https://doi.org/10.3892/mco.2018.1656
Copy and paste a formatted citation
x
Spandidos Publications style
Tamanuki T, Aoyagi T, Murano A and Matsuzaki H: Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report. Mol Clin Oncol 9: 215-218, 2018.
APA
Tamanuki, T., Aoyagi, T., Murano, A., & Matsuzaki, H. (2018). Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report. Molecular and Clinical Oncology, 9, 215-218. https://doi.org/10.3892/mco.2018.1656
MLA
Tamanuki, T., Aoyagi, T., Murano, A., Matsuzaki, H."Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report". Molecular and Clinical Oncology 9.2 (2018): 215-218.
Chicago
Tamanuki, T., Aoyagi, T., Murano, A., Matsuzaki, H."Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate‑induced osteonecrosis of the jaw: A case report". Molecular and Clinical Oncology 9, no. 2 (2018): 215-218. https://doi.org/10.3892/mco.2018.1656
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