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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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September-2018 Volume 9 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia

  • Authors:
    • Shinji Ohtake
    • Takashi Kawahara
    • Yukari Ishiguro
    • Teppei Takeshima
    • Shinnosuke Kuroda
    • Koji Izumi
    • Hiroshi Miyamoto
    • Hiroji Uemura
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236‑0004, Japan, Department of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan, Departments of Pathology and Laboratory Medicine, Urology, and Oncology, University of Rochester Medical Center, Rochester, NY 14627, USA
  • Pages: 302-304
    |
    Published online on: July 3, 2018
       https://doi.org/10.3892/mco.2018.1665
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Abstract

Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG. All cases expressed 8-OHdG. The levels of 8-OHdG expression in prostatic cancer (30.0% moderate and 70.0% strong) were significantly higher than those in benign prostatic hyperplasia (71.4% moderate and 28.6% strong; (p<0.01). Notably, 8-OHdG is expressed more highly in prostate cancer tissues in comparison to benign prostate tissues.
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Copy and paste a formatted citation
Spandidos Publications style
Ohtake S, Kawahara T, Ishiguro Y, Takeshima T, Kuroda S, Izumi K, Miyamoto H and Uemura H: Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia. Mol Clin Oncol 9: 302-304, 2018.
APA
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K. ... Uemura, H. (2018). Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia. Molecular and Clinical Oncology, 9, 302-304. https://doi.org/10.3892/mco.2018.1665
MLA
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K., Miyamoto, H., Uemura, H."Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia". Molecular and Clinical Oncology 9.3 (2018): 302-304.
Chicago
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K., Miyamoto, H., Uemura, H."Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia". Molecular and Clinical Oncology 9, no. 3 (2018): 302-304. https://doi.org/10.3892/mco.2018.1665
Copy and paste a formatted citation
x
Spandidos Publications style
Ohtake S, Kawahara T, Ishiguro Y, Takeshima T, Kuroda S, Izumi K, Miyamoto H and Uemura H: Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia. Mol Clin Oncol 9: 302-304, 2018.
APA
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K. ... Uemura, H. (2018). Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia. Molecular and Clinical Oncology, 9, 302-304. https://doi.org/10.3892/mco.2018.1665
MLA
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K., Miyamoto, H., Uemura, H."Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia". Molecular and Clinical Oncology 9.3 (2018): 302-304.
Chicago
Ohtake, S., Kawahara, T., Ishiguro, Y., Takeshima, T., Kuroda, S., Izumi, K., Miyamoto, H., Uemura, H."Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia". Molecular and Clinical Oncology 9, no. 3 (2018): 302-304. https://doi.org/10.3892/mco.2018.1665
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