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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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September-2018 Volume 9 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature

  • Authors:
    • Filipa Mousinho
    • Paula Sousa E. Santos
    • Ana P. Azevedo
    • José Manuel Pereira
    • Raquel Lemos
    • Sónia Matos
    • João Faro Viana
    • Fernando Lima
  • View Affiliations / Copyright

    Affiliations: Clinical Hematology Department, Hospital of São Francisco Xavier, West Lisbon Hospital Centre, 1449‑005 Lisbon, Portugal, Clinical Pathology Department, Hematology Laboratory, Hospital of São Francisco Xavier, West Lisbon Hospital Centre, 1449‑005 Lisbon, Portugal, Clinical Pathology Department, Flow Cytometry Laboratory, Hospital of São Francisco Xavier, West Lisbon Hospital Centre, 1449‑005 Lisbon, Portugal, CGC Genetics, 4000‑432 Porto, Portugal, GenoMed‑Molecular Medicine Diagnosis, Molecular Medicine Institute, Faculty of Medicine University of Lisbon, 1649‑028 Lisbon, Portugal
  • Pages: 347-349
    |
    Published online on: July 19, 2018
       https://doi.org/10.3892/mco.2018.1682
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Abstract

Patients with a Philadelphia chromosome-negative myeloproliferative neoplasm may develop a lymphoproliferative disorder; however, the clinical and molecular determinants and the chronological onset of the two events remain unknown. We herein report the case of a 64‑year‑old man with concomitant diagnosis of high‑risk essential thrombocythemia with evidence of a thrombotic event and high‑count monoclonal B‑cell lymphocytosis (high‑count MBL). The patient harbored a JAK2V617F mutation and one of the most common genetic alterations found in chronic lymphocytic leukemia (CLL) (del 13q), which may represent a sign of disease progression. He was initiated on cytoreductive therapy with hydroxyurea 500 mg 3 times per week and hypocoagulation treatment, and is currently under regular surveillance of MBL without CLL criteria.
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Copy and paste a formatted citation
Spandidos Publications style
Mousinho F, Santos PS, Azevedo AP, Pereira JM, Lemos R, Matos S, Viana JF and Lima F: Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature. Mol Clin Oncol 9: 347-349, 2018.
APA
Mousinho, F., Santos, P.S., Azevedo, A.P., Pereira, J.M., Lemos, R., Matos, S. ... Lima, F. (2018). Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature. Molecular and Clinical Oncology, 9, 347-349. https://doi.org/10.3892/mco.2018.1682
MLA
Mousinho, F., Santos, P. S., Azevedo, A. P., Pereira, J. M., Lemos, R., Matos, S., Viana, J. F., Lima, F."Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature". Molecular and Clinical Oncology 9.3 (2018): 347-349.
Chicago
Mousinho, F., Santos, P. S., Azevedo, A. P., Pereira, J. M., Lemos, R., Matos, S., Viana, J. F., Lima, F."Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature". Molecular and Clinical Oncology 9, no. 3 (2018): 347-349. https://doi.org/10.3892/mco.2018.1682
Copy and paste a formatted citation
x
Spandidos Publications style
Mousinho F, Santos PS, Azevedo AP, Pereira JM, Lemos R, Matos S, Viana JF and Lima F: Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature. Mol Clin Oncol 9: 347-349, 2018.
APA
Mousinho, F., Santos, P.S., Azevedo, A.P., Pereira, J.M., Lemos, R., Matos, S. ... Lima, F. (2018). Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature. Molecular and Clinical Oncology, 9, 347-349. https://doi.org/10.3892/mco.2018.1682
MLA
Mousinho, F., Santos, P. S., Azevedo, A. P., Pereira, J. M., Lemos, R., Matos, S., Viana, J. F., Lima, F."Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature". Molecular and Clinical Oncology 9.3 (2018): 347-349.
Chicago
Mousinho, F., Santos, P. S., Azevedo, A. P., Pereira, J. M., Lemos, R., Matos, S., Viana, J. F., Lima, F."Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature". Molecular and Clinical Oncology 9, no. 3 (2018): 347-349. https://doi.org/10.3892/mco.2018.1682
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