Radiation‑induced glioblastoma with rhabdoid characteristics following treatment for medulloblastoma: A case report and review of the literature

Wang,Ying; Song,Shujun; Su,Xiaoming; Wu,Jihua; Dai,Zhuojie; Cui,Di; Reng,Ye; Fan,Jingjing; Shen,Yulong; Wu,Qingqin; Wang,Zongye

doi:10.3892/mco.2018.1703

October-2018 Volume 9 Issue 4

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October-2018 Volume 9 Issue 4

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Case Report

Radiation‑induced glioblastoma with rhabdoid characteristics following treatment for medulloblastoma: A case report and review of the literature

Authors:
- Ying Wang
- Shujun Song
- Xiaoming Su
- Jihua Wu
- Zhuojie Dai
- Di Cui
- Ye Reng
- Jingjing Fan
- Yulong Shen
- Qingqin Wu
- Zongye Wang
View Affiliations / Copyright

Affiliations: Department of Radiotherapy, 306th Hospital of PLA, Beijing 100101, P.R. China, Center for Special Medicine and Experimental Research, 306th Hospital of PLA, Beijing 100101, P.R. China, Department of Pathology, 306th Hospital of PLA, Beijing 100101, P.R. China
Pages: 415-418
|
Published online on: August 20, 2018

https://doi.org/10.3892/mco.2018.1703
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Abstract

Glioblastoma multiforme (GBM) is a high‑grade glioma that may develop from several other central nervous system tumors after radiation therapy. We herein report a case of GBM occurring 8 years after radiation therapy for medulloblastoma. The secondary tumor was histologically distinctly different from the primary tumor. Previously reported cases indicate that GBM induced by radiation therapy is associated with a highly aggressive clinical course with a high risk of early recurrence and poor prognosis. In addition, histological examination revealed that the tumor cells exhibited characteristics of both GBM and rhabdoid tumor cells. The diverse pathological characteristics of GBM may reflect the potential effects of radiation therapy on the tumor.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Radiation‑induced glioblastoma with rhabdoid characteristics following treatment for medulloblastoma: A case report and review of the literature

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