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Article

Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study

  • Authors:
    • Miwako Omori
    • Yusuke Okuma
    • Taiki Hakozaki
    • Yukio Hosomi
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113‑867, Japan
  • Pages: 137-143
    |
    Published online on: November 13, 2018
       https://doi.org/10.3892/mco.2018.1765
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Abstract

There are a number of suggested predictive factors of nivolumab for non‑small cell lung cancer (NSCLC), however, there is not enough evidence to determine a single factor that can predict the efficacy of nivolumab. As the progress of biomarkers for cancer treatment is improving, it has been speculated that certain clinical factors serve an important role when predicting the outcome of chemotherapy. A total of 67 patients treated with nivolumab for NSCLC from 2016‑2017 were prospectively investigated. Age, sex, the Eastern Cooperative Oncology Group Performance Status, histology, epidermal growth factor receptor (EGFR) mutation, history of chemotherapy, smoking status, use of statins, use of fibrates, use of dipeptidyl peptidase‑4 (DPP‑4) inhibitors, and use of metformin were examined as clinical factors. Statistical analyses were performed using the Kaplan‑Meier method and Cox regression adjusted for risk factors and the tumor response of 67 patients was assessed. The patients had a median age of 67 years (range, 36‑87 years), and 46 males and 21 females were enrolled; performance status 0/1 was 59. Cases were categorized as adenocarcinoma (n=41), squamous cell carcinoma (n=17) and other (n=9). A total of 13 patients (19.4%) had EGFR mutations. These clinical factors were not statistically significant in overall survival (OS). Clinical laboratory findings, complications and use of medical agents including antidiabetes mellitus or lipidemia were also analyzed. Statins exhibited statistical significance for response (P=0.02). Time‑to‑treatment failure (TTF) in statin‑use group was not reached [95% confidence interval (CI): 1.9‑not reached] and was 4.0 months (95% CI: 2.0‑5.4) in the non‑statin group (P=0.039). The median OS in statin‑use group was not reached (95% CI: 8.7‑not reached) and was 16.5 months (95% CI: 7.5‑not reached) in the non‑statin group (P=0.058). NSCLC patients previously treated with nivolumab who were administered statins exhibited an increased response rate and longer TTF. This response was not statistically significant in OS.
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Copy and paste a formatted citation
Spandidos Publications style
Omori M, Okuma Y, Hakozaki T and Hosomi Y: Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study. Mol Clin Oncol 10: 137-143, 2019.
APA
Omori, M., Okuma, Y., Hakozaki, T., & Hosomi, Y. (2019). Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study. Molecular and Clinical Oncology, 10, 137-143. https://doi.org/10.3892/mco.2018.1765
MLA
Omori, M., Okuma, Y., Hakozaki, T., Hosomi, Y."Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study". Molecular and Clinical Oncology 10.1 (2019): 137-143.
Chicago
Omori, M., Okuma, Y., Hakozaki, T., Hosomi, Y."Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study". Molecular and Clinical Oncology 10, no. 1 (2019): 137-143. https://doi.org/10.3892/mco.2018.1765
Copy and paste a formatted citation
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Spandidos Publications style
Omori M, Okuma Y, Hakozaki T and Hosomi Y: Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study. Mol Clin Oncol 10: 137-143, 2019.
APA
Omori, M., Okuma, Y., Hakozaki, T., & Hosomi, Y. (2019). Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study. Molecular and Clinical Oncology, 10, 137-143. https://doi.org/10.3892/mco.2018.1765
MLA
Omori, M., Okuma, Y., Hakozaki, T., Hosomi, Y."Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study". Molecular and Clinical Oncology 10.1 (2019): 137-143.
Chicago
Omori, M., Okuma, Y., Hakozaki, T., Hosomi, Y."Statins improve survival in patients previously treated with nivolumab for advanced non‑small cell lung cancer: An observational study". Molecular and Clinical Oncology 10, no. 1 (2019): 137-143. https://doi.org/10.3892/mco.2018.1765
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