Histological complete response with nivolumab for renal cell carcinoma with multiple metastases: A case report

Shirotake,Suguru; Kaneko,Go; Nagata,Koji; Oyama,Masafumi; Nishimoto,Koshiro

doi:10.3892/mco.2018.1779

February-2019 Volume 10 Issue 2

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February-2019 Volume 10 Issue 2

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Case Report

Histological complete response with nivolumab for renal cell carcinoma with multiple metastases: A case report

Authors:
- Suguru Shirotake
- Go Kaneko
- Koji Nagata
- Masafumi Oyama
- Koshiro Nishimoto
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Affiliations: Department of Uro‑Oncology, Saitama Medical University International Medical Center, Saitama 350‑1298, Japan, Department of Diagnostic Pathology, Saitama Medical University International Medical Center, Saitama 350‑1298, Japan
Pages: 244-248
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Published online on: November 28, 2018

https://doi.org/10.3892/mco.2018.1779
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Abstract

The present case report describes a case of left renal clear cell carcinoma with brain, lung, para‑aortic, and lymph node metastases (cT1bN1M1) in a 52‑year‑old Japanese male. The patient received sequential anticancer treatments with pazopanib, everolimus, and axitinib, but exhibited treatment‑resistant tumor growth. Treatment with nivolumab resulted in a complete response in metastatic sites. However, the residual renal tumor, which was enhanced by contrast medium, required radical nephrectomy. Pathological analyses of the renal tumor revealed that it consisted of fibrotic and lymphocyte‑infiltrated tissues in which morphological cancer cells were not detected. The majority of lymphocytes were cluster of differentiation (CD)8‑positive, suggesting that cancer cells were attacked by these lymphocytes. Retrospective analyses of renal cell carcinoma tissues, which were biopsied before the anticancer treatment, revealed their infiltration by CD8‑positive T cells. To the best of our knowledge, this is the first case report to examine renal tissue prior to and following treatment with nivolumab using immunohistochemical analysis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Histological complete response with nivolumab for renal cell carcinoma with multiple metastases: A case report

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Abstract

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