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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2019 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report

  • Authors:
    • Akimasa Sekine
    • Hiroaki Satoh
    • Satoshi Ikeda
    • Tsuneyuki Oda
    • Koji Okudela
    • Tae Iwasawa
    • Takashi Ogura
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236‑0051, Japan, Department of Internal Medicine, Mito Medical Center, University of Tsukuba, Tsukuba, Ibaraki 310‑0015, Japan, Department of Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236‑0004, Japan, Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236‑0051, Japan
  • Pages: 451-453
    |
    Published online on: February 27, 2019
       https://doi.org/10.3892/mco.2019.1818
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Abstract

We herein report a case of symptomatic brain metastases (BM) from lung adenocarcinoma in a 73‑year‑old female patient, which developed during salvage cytotoxic chemotherapy following failure of osimertinib treatment. The patient was proven to have a T790M mutation prior to osimertinib therapy, and achieved a clinical benefit from osimertinib for 3 years until the primary tumor progressed. Although active BM were not detected prior to initiating salvage cytotoxic chemotherapy, the patient developed numbness of the left hand, severe dizziness, and disturbance of behavior and thought after the 3‑month course of the salvage cytotoxic chemotherapy. Brain magnetic resonance imaging revealed multiple BM with severe peritumoral brain edema. To avoid radiation‑induced cognitive impairment, osimertinib re‑challenge was undertaken. At 2 weeks after osimertinib initiation, the patient's neurological symptoms drastically improved. One month later, radiological evaluation revealed apparent shrinkage of the BM and subsiding brain edema, although the primary lung tumor remained stable. Therefore, osimertinib re‑challenge may be a viable treatment option for BM developing during salvage cytotoxic chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Sekine A, Satoh H, Ikeda S, Oda T, Okudela K, Iwasawa T and Ogura T: Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report. Mol Clin Oncol 10: 451-453, 2019.
APA
Sekine, A., Satoh, H., Ikeda, S., Oda, T., Okudela, K., Iwasawa, T., & Ogura, T. (2019). Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report. Molecular and Clinical Oncology, 10, 451-453. https://doi.org/10.3892/mco.2019.1818
MLA
Sekine, A., Satoh, H., Ikeda, S., Oda, T., Okudela, K., Iwasawa, T., Ogura, T."Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report". Molecular and Clinical Oncology 10.4 (2019): 451-453.
Chicago
Sekine, A., Satoh, H., Ikeda, S., Oda, T., Okudela, K., Iwasawa, T., Ogura, T."Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report". Molecular and Clinical Oncology 10, no. 4 (2019): 451-453. https://doi.org/10.3892/mco.2019.1818
Copy and paste a formatted citation
x
Spandidos Publications style
Sekine A, Satoh H, Ikeda S, Oda T, Okudela K, Iwasawa T and Ogura T: Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report. Mol Clin Oncol 10: 451-453, 2019.
APA
Sekine, A., Satoh, H., Ikeda, S., Oda, T., Okudela, K., Iwasawa, T., & Ogura, T. (2019). Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report. Molecular and Clinical Oncology, 10, 451-453. https://doi.org/10.3892/mco.2019.1818
MLA
Sekine, A., Satoh, H., Ikeda, S., Oda, T., Okudela, K., Iwasawa, T., Ogura, T."Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report". Molecular and Clinical Oncology 10.4 (2019): 451-453.
Chicago
Sekine, A., Satoh, H., Ikeda, S., Oda, T., Okudela, K., Iwasawa, T., Ogura, T."Rapid effect of osimertinib re‑challenge on brain metastases developing during salvage cytotoxic chemotherapy after osimertinib treatment failure: A case report". Molecular and Clinical Oncology 10, no. 4 (2019): 451-453. https://doi.org/10.3892/mco.2019.1818
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