Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-2019 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Mixed ductal-acinar cell carcinoma of the pancreas: A case report

  • Authors:
    • Takahiro Shigaki
    • Toru Hisaka
    • Fumihiko Fujita
    • Hironori Kusano
    • Yoshiki Naito
    • Ryuta Midorikawa
    • Takafumi Ohchi
    • Ichitaro Shiratsuchi
    • Atsuhiro Hidaka
    • Takaho Tanaka
    • Yoshito Akagi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan, Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan, Department of Surgery, Tagawa Hospital, Tagawa, Fukuoka 826-8585, Japan
  • Pages: 516-520
    |
    Published online on: March 20, 2019
       https://doi.org/10.3892/mco.2019.1831
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mixed carcinoma of the pancreas is defined as the concurrent existence of pancreatic ductal carcinoma, acinar cell carcinoma, and/or islet cell carcinoma within the same neoplasm. We herein report a rare case of mixed ductal‑acinar cell carcinoma in a 74‑year‑old man who was undergoing treatment for hypertension and diabetes at another hospital. After an abrupt worsening of his blood glucose control, the patient was referred to our hospital for further evaluation. Abdominal contrast‑enhanced computed tomography and magnetic resonance imaging revealed a tumor with a multilocular cystic lesion in the head of the pancreas. Endoscopic retrograde cholangiopancreatography revealed obstruction of the main pancreatic duct and dilation of the dorsal pancreatic duct; in addition, adenocarcinoma was detected in the pancreatic juice cytology. Based on the abovementioned findings, the patient was diagnosed with carcinoma of the pancreatic head and underwent subtotal stomach‑preserving pancreaticoduodenectomy. Based on the histopathological and immunohistochemical findings, the patient was diagnosed with mixed ductal‑acinar cell carcinoma. The patient was prescribed TS‑1 as postoperative adjuvant chemotherapy upon discharge. However, treatment was discontinued 2 months later due to marked general malaise, and the patient succumbed to tumor recurrence in the residual pancreas 12 months after the surgery.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ohike N, Jürgensen A, Pipeleers-Marichal M and Klöppel G: Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: Characterization of the endocrine cells. Virchows Arch. 442:258–265. 2003.PubMed/NCBI

2 

Hruban RH, Pitman MB and Klimstra DS: Tumors of the Pancreas, AFIP Atlas of Tumor Pathology. Fourth series, Fascicle. 6:American Registry of Pathology. (Washington, DC). 191–218. 2007.

3 

Bosman FT, Carneiro F, Hruban RH and Theise ND: WHO Classification of Tumours of the Digestive System. 9th. IARC/WHO; Lyon: pp. 279–337. 2010

4 

Shonaka T, Inagaki M, Akabane H, Yanagida N, Shomura H, Yanagawa N, Oikawa K and Nakano S: Total pancreatectomy for metachronous mixed acinar-ductal carcinoma in a remnant pancreas. World J Gastroenterol. 20:11904–11909. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Stelow EB, Shaco-Levy R, Bao F, Garcia J and Klimstra DS: Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Am J Surg Pathol. 34:510–518. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Webb JN: Acinar cell neoplasms of the exocrine pancreas. J Clin Pathol. 30:103–112. 1977. View Article : Google Scholar : PubMed/NCBI

7 

Sakata T, Mimura H, Takakura N, Hamazaki K, Kin H, Kimura T, Hosoba T, Orita K, Mizobuchi K, Taguchi K, et al: A case of mixed duct and acinar cell carcinoma the pancreas showing peculiar modes of spread. J Biliary Tract Pancreas. 8:1349–1353. 1987.(In Japanese).

8 

Inaba N, Kasahara K, Kashii A, Kanazawa K, Yamaguchi T, Saito K and Kamisawa T: Mixed ductal and acinar cell cancer of the pancreas head; report of a case. Nihon Geka Gakkai Zasshi. 88:773–778. 1987.(In Japanese). PubMed/NCBI

9 

Goto H, Yamazaki Y, Takeuchi T, Kokehara N, Ota M, Ohashi N, Kusakawa M and Soga T: Total pancreatectomy for combined carcinoma of the pancreas-report of a case. J Biliary Tract Pancreas. 9:463–467. 1988.(In Japanese).

10 

Sakai M, Takeda S, Ishikawa T, Kanazumi N, Inoue S, Kaneko T, Nakao A and Nagasaka T: Mixed duct-acinar cell carcinoma of the pancreas: Report of a case. Jpn J Gastroenterol Surg. 38:1821–1827. 2005. View Article : Google Scholar

11 

Fishman MP and Melton DA: Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol. 46:201–207. 2002.PubMed/NCBI

12 

Edlund H: Pancreas: How to get there from the gut? Curr Opin Cell Biol. 11:663–668. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Krapp A, Knöfler M, Ledermann B, Bürki K, Berney C, Zoerkler N, Hagenbüchle O and Wellauer PK: The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12:3752–3763. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL and Wright CV: PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 122:983–995. 1996.PubMed/NCBI

15 

Song KH, Ko SH, Ahn YB, Yoo SJ, Chin HM, Kaneto H, Yoon KH, Cha BY, Lee KW and Son HY: In vitro transdifferentiation of adult pancreatic acinar cells into insulin-expressing cells. Biochem Biophys Res Commun. 316:1094–1100. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T and Seino S: Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA. 102:15116–15121. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Ohike N and Morohoshi T: Pathological assessment of pancreatic endocrine tumors for metastatic potential and clinical prognosis. Endocr Pathol. 16:33–40. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Ohike N, Kosmahl M and Klöppel G: Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma. Virchows Arch. 445:231–235. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, Stamm B, Rüschoff J, Wiedenmann B and Klöppel G: Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. Am J Pathol. 143:685–698. 1993.PubMed/NCBI

20 

Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, Bassi C, Lemoine NR and Scarpa A: Pancreatic tumours: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br J Cancer. 84:253–262. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Terhune PG, Heffess CS and Longnecker DS: Only wild-type c-Ki-ras codons 12, 13, and 61 in human pancreatic acinar cell carcinomas. Mol Carcinog. 10:110–114. 1994. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shigaki T, Hisaka T, Fujita F, Kusano H, Naito Y, Midorikawa R, Ohchi T, Shiratsuchi I, Hidaka A, Tanaka T, Tanaka T, et al: Mixed ductal-acinar cell carcinoma of the pancreas: A case report. Mol Clin Oncol 10: 516-520, 2019.
APA
Shigaki, T., Hisaka, T., Fujita, F., Kusano, H., Naito, Y., Midorikawa, R. ... Akagi, Y. (2019). Mixed ductal-acinar cell carcinoma of the pancreas: A case report. Molecular and Clinical Oncology, 10, 516-520. https://doi.org/10.3892/mco.2019.1831
MLA
Shigaki, T., Hisaka, T., Fujita, F., Kusano, H., Naito, Y., Midorikawa, R., Ohchi, T., Shiratsuchi, I., Hidaka, A., Tanaka, T., Akagi, Y."Mixed ductal-acinar cell carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 10.5 (2019): 516-520.
Chicago
Shigaki, T., Hisaka, T., Fujita, F., Kusano, H., Naito, Y., Midorikawa, R., Ohchi, T., Shiratsuchi, I., Hidaka, A., Tanaka, T., Akagi, Y."Mixed ductal-acinar cell carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 10, no. 5 (2019): 516-520. https://doi.org/10.3892/mco.2019.1831
Copy and paste a formatted citation
x
Spandidos Publications style
Shigaki T, Hisaka T, Fujita F, Kusano H, Naito Y, Midorikawa R, Ohchi T, Shiratsuchi I, Hidaka A, Tanaka T, Tanaka T, et al: Mixed ductal-acinar cell carcinoma of the pancreas: A case report. Mol Clin Oncol 10: 516-520, 2019.
APA
Shigaki, T., Hisaka, T., Fujita, F., Kusano, H., Naito, Y., Midorikawa, R. ... Akagi, Y. (2019). Mixed ductal-acinar cell carcinoma of the pancreas: A case report. Molecular and Clinical Oncology, 10, 516-520. https://doi.org/10.3892/mco.2019.1831
MLA
Shigaki, T., Hisaka, T., Fujita, F., Kusano, H., Naito, Y., Midorikawa, R., Ohchi, T., Shiratsuchi, I., Hidaka, A., Tanaka, T., Akagi, Y."Mixed ductal-acinar cell carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 10.5 (2019): 516-520.
Chicago
Shigaki, T., Hisaka, T., Fujita, F., Kusano, H., Naito, Y., Midorikawa, R., Ohchi, T., Shiratsuchi, I., Hidaka, A., Tanaka, T., Akagi, Y."Mixed ductal-acinar cell carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 10, no. 5 (2019): 516-520. https://doi.org/10.3892/mco.2019.1831
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team