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Article

Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis

  • Authors:
    • Kentaro Sato
    • Takuya Miura
    • Satoko Morohashi
    • Yoshiyuki Sakamoto
    • Hajime Morohashi
    • Tatsuya Yoshida
    • Kenichi Hakamada
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Hirosaki University, Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Pathology and Bioscience, Hirosaki University, Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
  • Pages: 619-624
    |
    Published online on: March 28, 2019
       https://doi.org/10.3892/mco.2019.1835
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Abstract

Neoadjuvant chemoradiotherapy (NACRT) for lower rectal cancer is commonly used in many Western countries. NACRT improves local control, but it may also induce anal dysfunction, postoperative complications, and late effects associated with radiation. Neoadjuvant chemotherapy (NAC) for lower rectal cancer has recently been employed to improve these problems, but the local control effect of NAC when compared with NACRT is controversial. The aim of the present study was to compare the effects of NAC and NACRT using histopathological analysis. The subjects included 16 patients treated with NAC and 10 patients treated with NACRT prior to surgery. Pathological effects on primary lesions and lymph nodes were evaluated based on fibrosis and tumor depth prior to and following preoperative therapy. In the NAC and NACRT groups, the T downgrade rates were 87.5 and 80%, T depth/F depth ratios were 0.61 and 0.73, pathological T downgrade rates were 25 and 40%, pathological complete response rates were 12.5 and 0% for primary lesions and 33.3 and 37.5% for lymph nodes, and the N conversion rates were 80 and 37.5%. There were no significant differences between the groups. These results suggest that the pathological therapeutic effects of NAC were similar to those of NACRT, and NAC may be effective as an alternative therapy to NACRT.
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1 

De Caluwé L, Van Nieuwenhove Y and Ceelen WP: Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer. Cochrane Database Syst Rev. 28:22013.

2 

Marijnen CA, van de Velde CJ, Putter H, van den Brink M, Maas CP, Martijn H, Rutten HJ, Wiggers T, Kranenbark EK, Leer JW and Stiggelbout AM: Impact of short-term preoperative radio-therapy on health-related quality of life and sexual functioning in primary rectal cancer: Report of a multicenter randomized trial. J Clin Oncol. 23:1847–1858. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Camma C, Giunta M, Fiorica F, Pagliaro L, Craxì A and Cottone M: Preoperative radiotherapy for resectable rectal cancer: A meta-analysis. J Am Med Assoc. 284:1008–1015. 2000. View Article : Google Scholar

4 

Holm T, Rutqvist LE, Johansson H and Cedermark B: Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: Causes and risk factors. Br J Surg. 83:964–968. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Japanese Society for Cancer of the Colon Rectum, . Japanese Classification of Colorectal Carcinoma (8th edition). Kanehara Shuppan. Tokyo: 2013.

6 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplantat. 48:452–458. 2013. View Article : Google Scholar

7 

Frykholm GJ, Glimelius B and Pahlman L: Preoperative or postoperative irradiation in adenocarcinoma of the rectum: Final treatment results of a randomized trial and an evaluation of late secondary effects. Dis Colon Rectum. 36:864–872. 1993. View Article : Google Scholar

8 

Peeters KC, Marijnen CA, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T, Rutten H, Pahlman L, Glimelius B, Leer JW, et al: The TME trial after a median follow-up of 6 years: Increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 246:693–701. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Swedish Rectal Cancer Trial, . Cedermark B, Dahlberg M, Glimelius B, Påhlman L, Rutqvist LE and Wilking N: Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med. 336:980–987. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Bosset JF, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, Bardet E, Beny A, Briffaux A and Collette L: Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: Preliminary results-EORTC 22921. J Clin Oncol. 23:5620–5627. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Nakafusa Y, Hirohashi Y, Tanaka T, Kitajima Y, Sato S and Miyazaki K: Lateral lymph node dissection in treatment for advanced lower rectal cancer. Jpn J Gastroenterol Surg. 34:1512–1521. 2001. View Article : Google Scholar

12 

Ishii Y, Hasegawa H, Endo T, Okabayashi K, Ochiai H, Moritani K, Watanabe M and Kitagawa Y: Medium-term results of neoadjuvant systemic chemotherapy using irinotecan, 5-fluorouracil, and leucovorin in patients with locally advanced rectal cancer. Eur J Surg Oncol. 36:1061–1065. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Hasegawa J, Nishimura J, Mizushima T, Miyake Y, Kim HM, Takemoto H, Tamagawa H, Noura S, Fujii M, Fujie Y, et al: Neoadjuvant capecitabine and oxaliplatin (XELOX) combined with bevacizumab for high-risk localized rectal cancer. Cancer Chemother Pharmacol. 73:1079–1087. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Schrag D, Weiser MR, Goodman KA, Gonen M, Hollywood E, Cercek A, Reidy-Lagunes DL, Gollub MJ, Shia J, Guillem JG, et al: Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: A pilot trial. J Clin Oncol. 32:513–518. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Kamiya T, Uehara K, Nakayama G, Ishigure K, Kobayashi S, Hiramatsu K, Nakayama H, Yamashita K, Sakamoto E, Tojima Y, et al: Early results of multicenter phase II trial of perioperative oxaliplatin and capecitabine without radiotherapy for high-risk rectal cancer: CORONA I study. Eur J Surg Oncol. 42:829–835. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Hasegawa S, Goto S, Matsumoto T, Hida K, Kawada K, Matsusue R, Yamaguchi T, Nishitai R, Manaka D, Kato S, et al: A multicenter phase 2 study on the feasibility and efficacy of neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer. Ann Surg Oncol. 24:3587–3595. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Rödel C, Grabenbauer GG, Papadopoulos T, Hohenberger W, Schmoll HJ and Sauer R: Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J Clin Oncol. 21:3098–3104. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Tulchinsky H, Shmueli E, Figer A, Klausner JM and Rabau M: An interval >7 weeks between neoadjuvant therapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancer. Ann Surg Oncol. 15:2661–2667. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Roh MS, Colangelo LH, O'Connell MJ, Yothers G, Deutsch M, Allegra CJ, Kahlenberg MS, Baez-Diaz L, Ursiny CS, Petrelli NJ and Wolmark N: Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol. 27:5124–5130. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Sakuyama N, Kojima M, Kawano S, Akimoto T, Saito N, Ito M and Ochiai A: Histological differences between preoperative chemoradiotherapy and chemotherapy for rectal cancer: A clinicopathological study. Pathol Int. 66:273–280. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sato K, Miura T, Morohashi S, Sakamoto Y, Morohashi H, Yoshida T and Hakamada K: Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis. Mol Clin Oncol 10: 619-624, 2019.
APA
Sato, K., Miura, T., Morohashi, S., Sakamoto, Y., Morohashi, H., Yoshida, T., & Hakamada, K. (2019). Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis. Molecular and Clinical Oncology, 10, 619-624. https://doi.org/10.3892/mco.2019.1835
MLA
Sato, K., Miura, T., Morohashi, S., Sakamoto, Y., Morohashi, H., Yoshida, T., Hakamada, K."Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis". Molecular and Clinical Oncology 10.6 (2019): 619-624.
Chicago
Sato, K., Miura, T., Morohashi, S., Sakamoto, Y., Morohashi, H., Yoshida, T., Hakamada, K."Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis". Molecular and Clinical Oncology 10, no. 6 (2019): 619-624. https://doi.org/10.3892/mco.2019.1835
Copy and paste a formatted citation
x
Spandidos Publications style
Sato K, Miura T, Morohashi S, Sakamoto Y, Morohashi H, Yoshida T and Hakamada K: Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis. Mol Clin Oncol 10: 619-624, 2019.
APA
Sato, K., Miura, T., Morohashi, S., Sakamoto, Y., Morohashi, H., Yoshida, T., & Hakamada, K. (2019). Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis. Molecular and Clinical Oncology, 10, 619-624. https://doi.org/10.3892/mco.2019.1835
MLA
Sato, K., Miura, T., Morohashi, S., Sakamoto, Y., Morohashi, H., Yoshida, T., Hakamada, K."Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis". Molecular and Clinical Oncology 10.6 (2019): 619-624.
Chicago
Sato, K., Miura, T., Morohashi, S., Sakamoto, Y., Morohashi, H., Yoshida, T., Hakamada, K."Comparable regional therapeutic effects between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer in terms of histopathological analysis". Molecular and Clinical Oncology 10, no. 6 (2019): 619-624. https://doi.org/10.3892/mco.2019.1835
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