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An updated review of mucosal melanoma: Survival meta‑analysis

  • Authors:
    • Hyung Min Hahn
    • Kyoung Geun Lee
    • Won Choi
    • Seung Hyun Cheong
    • Ki Bum Myung
    • Hyung Jin Hahn
  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Ajou University School of Medicine, Suwon, Gyeonggi 16499, Republic of Korea, Department of Dermatology, College of Medicine, Konyang University, Daejeon, Chungcheongnam 35365, Republic of Korea
    Copyright: © Hahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 116-126
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    Published online on: May 29, 2019
       https://doi.org/10.3892/mco.2019.1870
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Abstract

Mucosal melanoma (MM) is a highly lethal variant of melanoma that carries a poor prognosis. Extremely low incidence and survival rates have led to few clinical trials, and a lack of protocols and guidelines. The present study performed a survival meta‑analysis for the quantitative synthesis of available evidence to search for key patterns that would help clinicians tailor optimal therapeutic strategies in MM. PubMed, EMBASE, Cochrane, MEDLINE, Google Scholar and other databases were searched. Hazard ratios, in disease‑specific and overall survival, were calculated for each of the survival‑determining variables. MM was 2.25 times more lethal than cutaneous melanoma (CM). The most significant threats to survival were advanced Tumor‑Node‑Metastasis stage, sino‑nasal location, and old age. Chemotherapy was the most effective form of adjuvant therapy. Disease‑specific survival, the primary measure of the effect sizes, can fluctuate depending on the accuracy of the reported cause of mortality. In conclusion, MM is a peculiar type of melanoma, with clinical and molecular profile vastly different from the much‑familiar CM. In the wake of the era of precision oncology, further studies on driver mutations and oncogenic pathways would likely lead to improved patient survival.
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1 

Patrick RJ, Fenske NA and Messina JL: Primary mucosal melanoma. J Am Acad Dermatol. 56:828–834. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Tacastacas JD, Bray J, Cohen YK, Arbesman J, Kim J, Koon HB, Honda K, Cooper KD and Gerstenblith MR: Update on primary mucosal melanoma. J Am Acad Dermatol. 71:366–375. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gru AA, Becker N, Dehner LP and Pfeifer JD: Mucosal melanoma: Correlation of clinicopathologic, prognostic, and molecular features. Melanoma Res. 24:360–370. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Thierauf J, Veit JA, Affolter A, Bergmann C, Grünow J, Laban S, Lennerz JK, Grünmüller L, Mauch C, Plinkert PK, et al: Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck. Melanoma Res. 25:503–509. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ragnarsson-Olding BK, Karsberg S, Platz A and Ringborg UK: Mutations in the TP53 gene in human malignant melanomas derived from sun-exposed skin and unexposed mucosal membranes. Melanoma Res. 12:453–463. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Zhu W, Li S, Zou B, Liu H and Wang S: Expressions and clinical significance of HER4 and CD44 in sinonasal mucosal malignant melanoma. Melanoma Res. 28:105–110. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB and Ahn KJ: Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma. J Am Acad Dermatol. 72:1036–46.e2. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Tierney JF, Stewart LA, Ghersi D, Burdett S and Sydes MR: Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 8:162007. View Article : Google Scholar : PubMed/NCBI

9 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA and Thacker SB: Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 283:2008–2012. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Moher D, Liberati A, Tetzlaff J and Altman DG; PRISMA Group, : Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 6:e10000972009. View Article : Google Scholar : PubMed/NCBI

11 

Ohashi A, Funasaka Y, Ueda M and Ichihashi M: c-KIT receptor expression in cutaneous malignant melanoma and benign melanotic naevi. Melanoma Res. 6:25–30. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Postow MA, Hamid O and Carvajal RD: Mucosal melanoma: Pathogenesis, clinical behavior, and management. Curr Oncol Rep. 14:441–448. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Altieri L, Wong MK, Peng DH and Cockburn M: Mucosal melanomas in the racially diverse population of California. J Am Acad Dermatol. 76:250–257. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Luna-Ortiz K, Aguilar-Romero M, Villavicencio-Valencia V, Zepeda-Castilla E, Vidrio-Morgado H, Peteuil N and Mosqueda-Taylor A: Comparative study between two different staging systems for mucosal melanomas of the Head and Neck. Med Oral Patol Oral Cir Bucal. 21:e425–e430. 2016.PubMed/NCBI

15 

Youssef D, Vasani S, Marquess J and Cervin A: Rising incidence of head and neck mucosal melanoma in Australia. J Laryngol Otol. 131:S25–S28. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Marcus DM, Marcus RP, Prabhu RS, Owonikoko TK, Lawson DH, Switchenko J and Beitler JJ: Rising incidence of mucosal melanoma of the head and neck in the United States. J Skin Cancer. 2012:2316932012. View Article : Google Scholar : PubMed/NCBI

17 

Abugideiri M, Patel K, Switchenko JM, Magliocca K, Buchwald ZS, Delgaudio J, Beitler JJ and Khan MK: Adjuvant radiation therapy improved local control for primary mucosal melanoma of the head and neck. Int J Radiation Oncol. 96:E384–E385. 2016. View Article : Google Scholar

18 

Ahn HJ, Na II, Park YH, Cho SY, Lee BC, Lee GH, Koh JS, Lee YS, Shim YS, Kim YK, et al: Role of adjuvant chemotherapy in malignant mucosal melanoma of the head and neck. Oral Oncol. 46:607–611. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Aiempanakit K, Chiratikarnwong K, Auepemkiate S and Sriplung H: Clinicopathologic characteristics and survival outcomes of primary mucosal melanomas: A 10-year retrospective analysis from a single tertiary medical center in Thailand. Zhonghua Pifuke Yixue Zazhi xxx. 1–3. 2018.

20 

Ajmani GS, Liederbach E, Kyrillos A, Wang CH, Pinto JM and Bhayani MK: Adjuvant radiation and survival following surgical resection of sinonasal melanoma. Am J Otolaryngol. 38:663–667. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Amit M, Tam S, Abdelmeguid AS, Roberts DB, Raza SM, Su SY, Kupferman ME, DeMonte F and Hanna EY: Approaches to regional lymph node metastasis in patients with head and neck mucosal melanoma. Cancer. 124:514–520. 2018. View Article : Google Scholar : PubMed/NCBI

22 

D'Angelo SP, Larkin J, Sosman JA, Lebbé C, Brady B, Neyns B, Schmidt H, Hassel JC, Hodi FS, Lorigan P, et al: Efficacy and safety of nivolumab alone or in combination with ipilimumab in patients with mucosal melanoma: A pooled analysis. J Clin Oncol. 35:226–235. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Benlyazid A, Thariat J, Temam S, Malard O, Florescu C, Choussy O, Makeieff M, Poissonnet G, Penel N, Righini C, et al: Postoperative radiotherapy in head and neck mucosal melanoma: A GETTEC study. Arch Otolaryngol Head Neck Surg. 136:1219–1225. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Bishop KD and Olszewski AJ: Epidemiology and survival outcomes of ocular and mucosal melanomas: A population-based analysis. Int J Cancer. 134:2961–2971. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Chiu NT and Weinstock MA: Melanoma of oronasal mucosa. Population-based analysis of occurrence and mortality. Arch Otolaryngol Head Neck Surg. 122:985–988. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Ciarrocchi A, Pietroletti R, Carlei F and Amicucci G: Extensive surgery and lymphadenectomy do not improve survival in primary melanoma of the anorectum: Results from analysis of a large database (SEER). Colorectal Dis. 19:158–164. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Ercelep O, Topcu TO, Bayoglu IV, Ekinci AS, Koca S, Kavgaci H, Ozcelik M, Alacacioglu A, Uzunoglu S, Bozkurt O, et al: Retrospective multicenter evaluation of patients diagnosed with mucosal melanoma: A study of Anatolian Society of Medical Oncology. Tumour Biol. 37:12033–12038. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Harada K, Mine S, Yamada K, Shigaki H, Oya S, Baba H and Watanabe M: Long-term outcome of esophagectomy for primary malignant melanoma of the esophagus: A single-institute retrospective analysis. Dis Esophagus. 29:314–319. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Hasebe M, Yoshikawa K, Nishii R, Kawaguchi K, Kamada T and Hamada Y: Usefulness of 11C-methionine-PET for predicting the efficacy of carbon ion radiation therapy for head and neck mucosal malignant melanoma. Int J Oral Maxillofac Surg. 46:1220–1228. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Heinzelmann-Schwarz VA, Nixdorf S, Valadan M, Diczbalis M, Olivier J, Otton G, Fedier A, Hacker NF and Scurry JP: A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker. Int J Mol Med. 33:784–794. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Heppt MV, Roesch A, Weide B, Gutzmer R, Meier F, Loquai C, Kähler KC, Gesierich A, Meissner M, von Bubnoff D, et al: Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma. Eur J Cancer. 81:36–44. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Hughes MC, Wright A, Barbour A, Thomas J, Smithers BM, Green AC and Khosrotehrani K: Patients undergoing lymphadenectomy for stage III melanomas of known or unknown primary site do not differ in outcome. Int J Cancer. 133:3000–3007. 2013.PubMed/NCBI

33 

Jang HS, Kim JH, Park KH, Lee JS, Bae JM, Oh BH, Rha SY, Roh MR and Chung KY: Comparison of melanoma subtypes among Korean patients by morphologic features and ultraviolet exposure. Ann Dermatol. 26:485–490. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kang X, Zeng Y, Liang J, Li J, Ren D, Chai L, Sun Z, Yu S, Wu X, Han W, et al: Aberrations and clinical significance of BRAF in malignant melanoma: A series of 60 cases in Chinese Uyghur. Medicine (Baltimore). 97:e95092018. View Article : Google Scholar : PubMed/NCBI

35 

Khan MN, Kanumuri VV, Raikundalia MD, Vazquez A, Govindaraj S, Baredes S and Eloy JA: Sinonasal melanoma: Survival and prognostic implications based on site of involvement. Int Forum Allergy Rhinol. 4:151–155. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Kirchoff DD, Deutsch GB, Foshag LJ, Lee JH, Sim MS and Faries MB: Evolving Therapeutic Strategies in Mucosal Melanoma Have Not Improved Survival Over Five Decades. Am Surg. 82:1–5. 2016.PubMed/NCBI

37 

Kirschner AN, Kidd EA, Dewees T and Perkins SM: Treatment approach and outcomes of vaginal melanoma. Int J Gynecol Cancer. 23:1484–1489. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Kong Y, Si L, Li Y, Wu X, Xu X, Dai J, Tang H, Ma M, Chi Z, Sheng X, et al: Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors. Clin Cancer Res. 22:1018–1027. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Konuthula N, Khan MN, Parasher A, Del Signore A, Genden EM, Govindaraj S and Iloreta AM: The presentation and outcomes of mucosal melanoma in 695 patients. Int Forum Allergy Rhinol. 7:99–105. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Koto M, Demizu Y, Saitoh JI, Suefuji H, Tsuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Nemoto K, et al Japan Carbon-Ion Radiation Oncology Study Group, : Multicenter study of carbon-ion radiation therapy for mucosal melanoma of the head and neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN). Int J Radiat Oncol Biol Phys. 97:1054–1060. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Kuk SK, Won CH, Lee WJ, Shin WJ, Yoon HJ, Hong SD, Hong SP and Lee J: Prognostic significance of nestin in primary malignant melanoma of the oral cavity. Melanoma Res. 26:457–463. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Lansu J, Klop WM, Heemsbergen W, Navran A, Al-Mamgani A, Langendijk JA, Kaanders JH, Terhaard C, Karakullukcu B and Hamming-Vrieze O: Local control in sinonasal malignant melanoma: Comparing conventional to hypofractionated radiotherapy. Head Neck. 40:86–93. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Lawaetz M, Birch-Johansen F, Friis S, Eriksen JG, Kiss K, Gade S, Møller-Madsen M, Pourbordbari N and von Buchwald C: Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study. Acta Oncol. 55:1001–1008. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Lee G, Baek CH, Choi NY and Chung MK: The prognostic role of the surgical approach and adjuvant therapy in operable mucosal melanoma of the head and neck. Clin Exp Otorhinolaryngol. 10:97–103. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Lee RJ, Lee SA, Lin T, Lee KK and Christensen RE: Determining the epidemiologic, outcome, and prognostic factors of oral malignant melanoma by using the Surveillance, Epidemiology, and End Results database. J Am Dent Assoc. 148:288–297. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Lombardi D, Bottazzoli M, Turri-Zanoni M, Raffetti E, Villaret AB, Morassi ML, Ungari M, Vermi W, Battaglia P, Castelnuovo P, et al: Sinonasal mucosal melanoma: A 12-year experience of 58 cases. Head Neck. 38 (Suppl 1):E1737–E1745. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Mücke T, Hölzle F, Kesting MR, Loeffelbein DJ, Robitzky LK, Hohlweg-Majert B, Tannapfel A and Wolff KD: Tumor size and depth in primary malignant melanoma in the oral cavity influences survival. J Oral Maxillofac Surg. 67:1409–1415. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Nakamura Y, Fujisawa Y, Tanaka R, Maruyama H, Ishitsuka Y, Okiyama N, Watanabe R and Fujimoto M: Use of immune checkpoint inhibitors prolonged overall survival in a Japanese population of advanced malignant melanoma patients: Retrospective single institutional study. J Dermatol. 45:1337–1339. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Oba J, Nakahara T, Abe T, Hagihara A, Moroi Y and Furue M: Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: An immunohistochemical study and analysis of prognostic value. J Dermatol Sci. 62:116–123. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Pandey M, Mathew A, Iype EM, Sebastian P, Abraham EK and Nair KM: Primary malignant mucosal melanoma of the head and neck region: Pooled analysis of 60 published cases from India and review of literature. Eur J Cancer Prev. 11:3–10. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Pfeil AF, Leiter U, Buettner PG, Eigentler TK, Weide B, Meier F and Garbe C: Melanoma of unknown primary is correctly classified by the AJCC melanoma classification from 2009. Melanoma Res. 21:228–234. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Plavc G, But-Hadžić J, Aničin A, Lanišnik B, Didanović V and Strojan P: Mucosal melanoma of the head and neck: A population-based study from Slovenia, 1985–2013. Radiat Oncol. 11:1372016. View Article : Google Scholar : PubMed/NCBI

53 

Roh MR, Gupta S, Park KH, Chung KY, Lauss M, Flaherty KT, Jönsson G, Rha SY and Tsao H: Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival. J Invest Dermatol. 136:1002–1011. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Samstein RM, Carvajal RD, Postow MA, Callahan MK, Shoushtari AN, Patel SG, Lee NY and Barker CA: Localized sinonasal mucosal melanoma: Outcomes and associations with stage, radiotherapy, and positron emission tomography response. Head Neck. 38:1310–1317. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Sanchez A, Rodríguez D, Allard CB, Bechis SK, Sullivan RJ, Boeke CE, Kuppermann D, Cheng JS, Barrisford GW, Preston MA, et al: Primary genitourinary melanoma: Epidemiology and disease-specific survival in a large population-based cohort. Urol Oncol. 34:166.e7–166.e14. 2016. View Article : Google Scholar

56 

Schaefer T, Satzger I and Gutzmer R: Clinics, prognosis and new therapeutic options in patients with mucosal melanoma: A retrospective analysis of 75 patients. Medicine (Baltimore). 96:e57532017. View Article : Google Scholar : PubMed/NCBI

57 

Schmidt MQ, David J, Yoshida EJ, Scher K, Mita A, Shiao SL, Ho AS and Zumsteg ZS: Predictors of survival in head and neck mucosal melanoma. Oral Oncol. 73:36–42. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Shoushtari AN, Bluth MJ, Goldman DA, Bitas C, Lefkowitz RA, Postow MA, Munhoz RR, Buchar G, Hester RH, Romero JA, et al: Clinical features and response to systemic therapy in a historical cohort of advanced or unresectable mucosal melanoma. Melanoma Res. 27:57–64. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Shuman AG, Light E, Olsen SH, Pynnonen MA, Taylor JM, Johnson TM and Bradford CR: Mucosal melanoma of the head and neck: Predictors of prognosis. Arch Otolaryngol Head Neck Surg. 137:331–337. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Song H, Jing G, Wang L, Guo W and Ren G: Periodic acid-Schiff-positive loops and networks as a prognostic factor in oral mucosal melanoma. Melanoma Res. 26:145–152. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Sun CZ, Li QL, Hu ZD, Jiang YE, Song M and Yang AK: Treatment and prognosis in sinonasal mucosal melanoma: A retrospective analysis of 65 patients from a single cancer center. Head Neck. 36:675–681. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Tchelebi L, Guirguis A and Ashamalla H: Rectal melanoma: Epidemiology, prognosis, and role of adjuvant radiation therapy. J Cancer Res Clin Oncol. 142:2569–2575. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Thariat J, Poissonnet G, Marcy PY, Lattes L, Butori C, Guevara N, Dassonville O, Santini J, Bensadoun RJ and Castillo L: Effect of surgical modality and hypofractionated split-course radiotherapy on local control and survival from sinonasal mucosal melanoma. Clin Oncol (R Coll Radiol). 23:579–586. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Wang X, Wen W, Wu H, Chen Y, Ren G and Guo W: Heparanase expression correlates with poor survival in oral mucosal melanoma. Med Oncol. 30:6332013. View Article : Google Scholar : PubMed/NCBI

65 

Wen X, Ding Y, Li J, Zhao J, Peng R, Li D, Zhu B, Wang Y and Zhang X and Zhang X: The experience of immune checkpoint inhibitors in Chinese patients with metastatic melanoma: A retrospective case series. Cancer Immunol Immunother. 66:1153–1162. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Won TB, Choi KY, Rhee CS, Jin HR, Yi JS, Dhong HJ, Kim SW, Choi JH, Kim JK, Chung YJ, et al: Treatment outcomes of sinonasal malignant melanoma: A Korean multicenter study. Int Forum Allergy Rhinol. 5:950–959. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Yeh JJ, Shia J, Hwu WJ, Busam KJ, Paty PB, Guillem JG, Coit DG, Wong WD and Weiser MR: The role of abdominoperineal resection as surgical therapy for anorectal melanoma. Ann Surg. 244:1012–1017. 2006. View Article : Google Scholar : PubMed/NCBI

68 

Yi JH, Yi SY, Lee HR, Lee SI, Lim DH, Kim JH, Park KW and Lee J: Dacarbazine-based chemotherapy as first-line treatment in noncutaneous metastatic melanoma: Multicenter, retrospective analysis in Asia. Melanoma Res. 21:223–227. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hahn HM, Lee KG, Choi W, Cheong SH, Myung KB and Hahn HJ: An updated review of mucosal melanoma: Survival meta‑analysis. Mol Clin Oncol 11: 116-126, 2019.
APA
Hahn, H.M., Lee, K.G., Choi, W., Cheong, S.H., Myung, K.B., & Hahn, H.J. (2019). An updated review of mucosal melanoma: Survival meta‑analysis. Molecular and Clinical Oncology, 11, 116-126. https://doi.org/10.3892/mco.2019.1870
MLA
Hahn, H. M., Lee, K. G., Choi, W., Cheong, S. H., Myung, K. B., Hahn, H. J."An updated review of mucosal melanoma: Survival meta‑analysis". Molecular and Clinical Oncology 11.2 (2019): 116-126.
Chicago
Hahn, H. M., Lee, K. G., Choi, W., Cheong, S. H., Myung, K. B., Hahn, H. J."An updated review of mucosal melanoma: Survival meta‑analysis". Molecular and Clinical Oncology 11, no. 2 (2019): 116-126. https://doi.org/10.3892/mco.2019.1870
Copy and paste a formatted citation
x
Spandidos Publications style
Hahn HM, Lee KG, Choi W, Cheong SH, Myung KB and Hahn HJ: An updated review of mucosal melanoma: Survival meta‑analysis. Mol Clin Oncol 11: 116-126, 2019.
APA
Hahn, H.M., Lee, K.G., Choi, W., Cheong, S.H., Myung, K.B., & Hahn, H.J. (2019). An updated review of mucosal melanoma: Survival meta‑analysis. Molecular and Clinical Oncology, 11, 116-126. https://doi.org/10.3892/mco.2019.1870
MLA
Hahn, H. M., Lee, K. G., Choi, W., Cheong, S. H., Myung, K. B., Hahn, H. J."An updated review of mucosal melanoma: Survival meta‑analysis". Molecular and Clinical Oncology 11.2 (2019): 116-126.
Chicago
Hahn, H. M., Lee, K. G., Choi, W., Cheong, S. H., Myung, K. B., Hahn, H. J."An updated review of mucosal melanoma: Survival meta‑analysis". Molecular and Clinical Oncology 11, no. 2 (2019): 116-126. https://doi.org/10.3892/mco.2019.1870
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