Malignant peritoneal mesothelioma diagnosed 50 years post‑radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case

Ohya,Maki; Kobayashi,Mikiko; Sozuki,Toshiro; Kanno,Hiroyuki; Nakazawa,Koh

doi:10.3892/mco.2019.1906

Malignant peritoneal mesothelioma diagnosed 50 years post‑radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case

Authors:
- Maki Ohya
- Mikiko Kobayashi
- Toshiro Sozuki
- Hiroyuki Kanno
- Koh Nakazawa
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Affiliations: Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano 390‑8621, Japan, Department of Respiratory Medicine, National Hospital Organization Matsumoto Medical Center, Matsumoto, Nagano 399‑8701, Japan, Department of Laboratory Medicine, National Hospital Organization Matsumoto Medical Center, Matsumoto, Nagano 399‑8701, Japan
Published online on: August 2, 2019 https://doi.org/10.3892/mco.2019.1906
Pages: 397-400

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Abstract

As the number of long‑term cancer survivors is increasing, the incidence of post‑irradiation malignant mesothelioma may also increase. We herein present the case of an 85‑year‑old female patient with a history of several surgeries for solid tumors and radiotherapy to the pelvis, who presented with abdominal pain and diarrhea. The patient's general condition gradually worsened and she succumbed to cardiopulmonary arrest triggered by vomiting ~3 months after the onset of the abdominal symptoms. An autopsy revealed malignant intestinal obstruction caused by peritoneal mesothelioma. Irradiation is a known risk factor for malignant mesothelioma, which may develop ~10‑30 years after radiotherapy. To the best of our knowledge, this is the first report of a patient with malignant mesothelioma developing ~50 years after radiotherapy. The aim of the present study was to remind physicians that malignant mesothelioma should be considered in the differential diagnosis of patients with a history of radiotherapy who present with gastrointestinal symptoms.

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