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Molecular and Clinical Oncology
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Article

Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma

  • Authors:
    • Tetsuo Fujita
    • Takahiro Hirayama
    • Morihiro Nishi
    • Kazumasa Matsumoto
    • Kazunari Yoshida
    • Masatsugu Iwamura
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan
  • Pages: 505-510
    |
    Published online on: September 18, 2019
       https://doi.org/10.3892/mco.2019.1924
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Abstract

Third‑line sunitinib is occasionally used for selected patients with metastatic renal cell carcinoma (mRCC). The aim of the present study was to evaluate the clinical significance of third‑line sunitinib after failure of first‑line cytokine therapy and second‑line sorafenib in patients with clear‑cell mRCC. A total of 14 consecutive patients with clear‑cell mRCC treated with third‑line sunitinib between December 2008 and February 2012 were enrolled in the present study. Disease control rate (DCR), progression‑free survival (PFS), overall survival (OS), and relative dose intensity (RDI) were compared with those of first‑line (n=20) and second‑line (n=14) sunitinib treatment. The DCR was 42.9%, the median PFS was 12.0 months, and the median OS was 20.0 months for third‑line sunitinib; there were no statistically significant differences compared with first‑line and second‑line sunitinib. The mean RDI was significantly lower for third‑line sunitinib compared with first‑ and second‑line sunitinib (P=0.0003 and 0.0109, respectively). Therefore, third‑line sunitinib is an effective treatment option for selected patients with mRCC, as optimized therapeutic efficacy was obtained with a relatively low dose of sunitinib.
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Copy and paste a formatted citation
Spandidos Publications style
Fujita T, Hirayama T, Nishi M, Matsumoto K, Yoshida K and Iwamura M: Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma. Mol Clin Oncol 11: 505-510, 2019.
APA
Fujita, T., Hirayama, T., Nishi, M., Matsumoto, K., Yoshida, K., & Iwamura, M. (2019). Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma. Molecular and Clinical Oncology, 11, 505-510. https://doi.org/10.3892/mco.2019.1924
MLA
Fujita, T., Hirayama, T., Nishi, M., Matsumoto, K., Yoshida, K., Iwamura, M."Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma". Molecular and Clinical Oncology 11.5 (2019): 505-510.
Chicago
Fujita, T., Hirayama, T., Nishi, M., Matsumoto, K., Yoshida, K., Iwamura, M."Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma". Molecular and Clinical Oncology 11, no. 5 (2019): 505-510. https://doi.org/10.3892/mco.2019.1924
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita T, Hirayama T, Nishi M, Matsumoto K, Yoshida K and Iwamura M: Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma. Mol Clin Oncol 11: 505-510, 2019.
APA
Fujita, T., Hirayama, T., Nishi, M., Matsumoto, K., Yoshida, K., & Iwamura, M. (2019). Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma. Molecular and Clinical Oncology, 11, 505-510. https://doi.org/10.3892/mco.2019.1924
MLA
Fujita, T., Hirayama, T., Nishi, M., Matsumoto, K., Yoshida, K., Iwamura, M."Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma". Molecular and Clinical Oncology 11.5 (2019): 505-510.
Chicago
Fujita, T., Hirayama, T., Nishi, M., Matsumoto, K., Yoshida, K., Iwamura, M."Outcome of third‑line sunitinib after sequential therapy with cytokines and sorafenib in metastatic renal cell carcinoma". Molecular and Clinical Oncology 11, no. 5 (2019): 505-510. https://doi.org/10.3892/mco.2019.1924
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