Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
January-2020 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2020 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Jia‑Kai Li
    • Xiao‑Hui Liu
    • Hong Cui
    • Xin‑Hui Xie
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Hainan Hospital of PLA General Hospital, Sanya, Hainan 572013, P.R. China, Department of Medical Psychology, Chinese PLA General Hospital and Medical School PLA, Beijing 100853, P.R. China, Department of Medical Psychology, Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 15-22
    |
    Published online on: October 31, 2019
       https://doi.org/10.3892/mco.2019.1941
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The treatment of hepatocellular carcinoma (HCC) is a significant challenge. Although radiofrequency ablation (RFA) has emerged as a popular therapeutic option for patients with resectable HCC, whether it can achieve comparable survival outcomes compared with surgical resection (RES) remains unclear. The aim of the present study was to conduct a meta‑analysis to assess the survival outcomes of RFA vs. RES in patients with early resectable HCC tumors. A Medline, Embase, and Cochrane Library search was performed for data published between January 2000 and February 2018. A meta‑analysis of the efficacy of RFA compared with RES for HCC was subsequently performed, with particular emphasis on overall survival and disease‑free survival (DFS) rates. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the random‑effects model. In the present study, a total of 13,147 patients with HCC were included; of which, 6,727 were treated with RFA and 6,420 were treated with RES. The overall survival rates (OR1‑year, 0.757, 95% CI, 0.578‑0.989; OR3‑year, 0.530, 95% CI, 0.401‑0.700; OR5‑year, 0.566, 95% CI, 0.423‑0.758) and the DRS rates (OR1‑year, 0.569, 95% CI, 0.456‑0.711; OR3‑year, 0.418, 95% CI, 0.267‑0.653; OR5‑year, 0.374, 95% CI, 0.231‑0.606) of RES were significantly higher than those of RFA. The results indicate that RES is superior to RFA for promoting the survival of selected patients with resectable HCC. However, future randomized controlled trials are required to investigate the specific relevance of these modalities in the treatment of HCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Bosch FX, Ribes J and Borras J: Epidemiology of primary liver cancer. Semin Liver Dis. 19:271–285. 1999. View Article : Google Scholar : PubMed/NCBI

2 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Taylor-Robinson SD, Foster GR, Arora S, Hargreaves S and Thomas HC: Increase in primary liver cancer in the UK, 1979–94. Lancet. 350:1142–1143. 1997. View Article : Google Scholar : PubMed/NCBI

4 

El-Serag HB and Mason AC: Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 340:745–750. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Malago M, Rogiers X and Broelsch CE: Liver splitting and living donor techniques. Br Med Bull. 53:860–867. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Ryder SD; British Society of Gastroenterology, : Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut. 52 (Suppl 3):iii1–iii8. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Johnson PJ: Hepatocellular carcinoma: Is current therapy really altering outcome? Gut. 51:459–462. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Bruix J and Llovet JM: Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology. 35:519–524. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M and Rodés J; EASL Panel of Experts on HCC, : Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 35:421–430. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Livraghi T: Guidelines for treatment of liver cancer. Eur J Ultrasound. 13:167–176. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Lai EC, Fan ST, Lo CM, Chu KM, Liu CL and Wong J: Hepatic resection for hepatocellular carcinoma. An audit of 343 patients. Ann Surg. 221:291–298. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Marin-Hargreaves G, Azoulay D and Bismuth H: Hepatocellular carcinoma: Surgical indications and results. Crit Rev Oncol Hematol. 47:13–27. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Arii S, Yamaoka Y, Futagawa S, Inoue K, Kobayashi K, Kojiro M, Makuuchi M, Nakamura Y, Okita K and Yamada R: Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology. 32:1224–1229. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Fried MW: Treatment of hepatocellular carcinoma: Medical options. Liver Transpl Surg. 4((5 Suppl 1)): S92–S97. 1998.PubMed/NCBI

15 

Ogihara M, Wong LL and Machi J: Radiofrequency ablation versus surgical resection for single nodule hepatocellular carcinoma: Long-term outcomes. HPB (Oxford). 7:214–221. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Ogata S, Belghiti J, Varma D, Sommacale D, Maeda A, Dondero F and Sauvanet A: Two hundred liver hanging maneuvers for major hepatectomy: A single-center experience. Ann Surg. 245:31–35. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Li L, Zhang J, Liu X, Li X, Jiao B and Kang T: Clinical outcomes of radiofrequency ablation and surgical resection for small hepatocellular carcinoma: A meta-analysis. J Gastroenterol Hepatol. 27:51–58. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ng KKC, Chok KSH, Chan ACY, Cheung TT, Wong TCL, Fung JYY, Yuen J, Poon RTP, Fan ST and Lo CM: Randomized clinical trial of hepatic resection versus radiofrequency ablation for early-stage hepatocellular carcinoma. Br J Surg. 104:1755–1784. 2017. View Article : Google Scholar

19 

Machi J, Uchida S, Sumida K, Limm WM, Hundahl SA, Oishi AJ, Furumoto NL and Oishi RH: Ultrasound-guided radiofrequency thermal ablation of liver tumors: Percutaneous, laparoscopic, and open surgical approaches. J Gastrointest Surg. 5:477–489. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Poon RT, Fan ST, Tsang FH and Wong J: Locoregional therapies for hepatocellular carcinoma: A critical review from the surgeon's perspective. Ann Surg. 235:466–486. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Chen MS, Li JQ, Zheng Y, Guo RP, Liang HH, Zhang YQ, Lin XJ and Lau WY: A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Ann Surg. 243:321–328. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Huang J, Yan L, Cheng Z, Wu H, Du L, Wang J, Xu Y and Zeng Y: A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria. Ann Surg. 252:903–912. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Feng K, Yan J, Li X, Xia F, Ma K, Wang S, Bie P and Dong J: A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. J Hepatol. 57:794–802. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Hong SN, Lee SY, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC, Rhee JC, Choi D, Lim HK, et al: Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic function. J Clin Gastroenterol. 39:247–252. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Montorsi M, Santambrogio R, Bianchi P, Donadon M, Moroni E, Spinelli A and Costa M: Survival and recurrences after hepatic resection or radiofrequency for hepatocellular carcinoma in cirrhotic patients: A multivariate analysis. J Gastrointest Surg. 9:62–67; discussion 67–68. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Nishikawa H, Inuzuka T, Takeda H, Nakajima J, Matsuda F, Sakamoto A, Henmi S, Hatamaru K, Ishikawa T, Saito S, et al: Comparison of percutaneous radiofrequency thermal ablation and surgical resection for small hepatocellular carcinoma. BMC Gastroenterol. 11:1432011. View Article : Google Scholar : PubMed/NCBI

27 

Vivarelli M, Guglielmi A, Ruzzenente A, Cucchetti A, Bellusci R, Cordiano C and Cavallari A: Surgical resection versus percutaneous radiofrequency ablation in the treatment of hepatocellular carcinoma on cirrhotic liver. Ann Surg. 240:102–107. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Xu G, Qi FZ, Zhang JH, Cheng GF, Cai Y and Miao Y: Meta-analysis of surgical resection and radiofrequency ablation for early hepatocellular carcinoma. World J Surg Oncol. 10:1632012. View Article : Google Scholar : PubMed/NCBI

29 

Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L, Tinelli C and Rossi S: Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice? Hepatology. 47:82–89. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, et al: Treatment strategy for early hepatocellular carcinomas: Comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection. J Surg Oncol. 104:3–9. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Abu-Hilal M, Primrose JN, Casaril A, McPhail MJ, Pearce NW and Nicoli N: Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma. J Gastrointest Surg. 12:1521–1526. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Liu JG, Wang YJ and Du Z: Radiofrequency ablation in the treatment of small hepatocellular carcinoma: A meta analysis. World J Gastroenterol. 16:3450–3456. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Cho YK, Rhim H and Noh S: Radiofrequency ablation versus surgical resection as primary treatment of hepatocellular carcinoma meeting the Milan criteria: A systematic review. J Gastroenterol Hepatol. 26:1354–1360. 2011.PubMed/NCBI

34 

Zhou Y, Zhao Y, Li B and Xu D: Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma. BMC Gastroenterol. 10:782010. View Article : Google Scholar : PubMed/NCBI

35 

Xu XL, Liu XD, Liang M and Luo BM: Radiofrequency ablation versus hepatic resection for small hepatacellular carcinoma: Systematic review of randomized controlled trials with meta-analysis and trial sequential analysis. Radiology. 287:461–472. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ and McQuay HJ: Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 17:1–12. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M and Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.evidencebasedpublichealth.de/download/Newcastle_Ottowa_Scale_Pope_Bruce.pdf

38 

Borenstein M, Hedges L, Higgins JPT and Rothstein H: Fixed effect vs. random effectsIntroduction to Meta-Analysis. John Wiley and Sons Ltd.; Chichester, UK: 2009, View Article : Google Scholar

39 

Yakoub D, Athanasiou T, Tekkis P and Hanna GB: Laparoscopic assisted distal gastrectomy for early gastric cancer: Is it an alternative to the open approach? Surg Oncol. 18:322–333. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Huang J, Hernandez-Alejandro R, Croome KP, Yan L, Wu H, Chen Z, Prasoon P and Zeng Y: Radiofrequency ablation versus surgical resection for hepatocellular carcinoma in Childs A cirrhotics-a retrospective study of 1,061 cases. J Gastrointest Surg. 15:311–320. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Peng ZW, Lin XJ, Zhang YJ, Liang HH, Guo RP, Shi M and Chen MS: Radiofrequency ablation versus hepatic resection for the treatment of hepatocellular carcinomas 2 cm or smaller: A retrospective comparative study. Radiology. 262:1022–1033. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Sironi S, Livraghi T, Meloni F, De Cobelli F, Ferrero C and Del Maschio A: Small hepatocellular carcinoma treated with percutaneous RF ablation: MR imaging follow-up. AJR Am J Roentgenol. 173:1225–1229. 1999. View Article : Google Scholar : PubMed/NCBI

43 

Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Ierace T, Solbiati L and Gazelle GS: Hepatocellular carcinoma: Radio-frequency ablation of medium and large lesions. Radiology. 214:761–768. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Livraghi T, Solbiati L, Meloni MF, Gazelle GS, Halpern EF and Goldberg SN: Treatment of focal liver tumors with percutaneous radio-frequency ablation: Complications encountered in a multicenter study. Radiology. 226:441–451. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Goldberg SN and Gazelle GS: Radiofrequency tissue ablation: Physical principles and techniques for increasing coagulation necrosis. Hepatogastroenterology. 48:359–367. 2001.PubMed/NCBI

46 

Miao Y, Ni Y, Yu J and Marchal G: A comparative study on validation of a novel cooled-wet electrode for radiofrequency liver ablation. Invest Radiol. 35:438–444. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Goldberg SN, Gazelle GS, Solbiati L, Rittman WJ and Mueller PR: Radiofrequency tissue ablation: Increased lesion diameter with a perfusion electrode. Acad Radiol. 3:636–644. 1996. View Article : Google Scholar : PubMed/NCBI

48 

Sasaki A, Kai S, Iwashita Y, Hirano S, Ohta M and Kitano S: Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma. Cancer. 103:299–306. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Shiina S, Tagawa K, Unuma T, Takanashi R, Yoshiura K, Komatsu Y, Hata Y, Niwa Y, Shiratori Y and Terano A: Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study. Cancer. 68:1524–1530. 1991. View Article : Google Scholar : PubMed/NCBI

50 

Mulier S, Ni Y, Jamart J, Ruers T, Marchal G and Michel L: Local recurrence after hepatic radiofrequency coagulation: Multivariate meta-analysis and review of contributing factors. Ann Surg. 242:158–171. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Park EK, Kim HJ, Kim CY, Hur YH, Koh YS, Kim JC, Kim HJ, Kim JW and Cho CK: A comparison surgical resection and radiofrequency ablation in the treatment of hepatocellular carcinoma. Ann Surg Treat Res. 87:72–80. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Kutlu OC, Chan JA, Aloia TA, Chun YS, Kaseb AO, Passot G, Yamashita S, Vauthey JN and Conrad C: Comparative effectiveness of first-line radiofrequency ablation versus surgical resection and transplantation for patents with early hepatocellular carcinoma. Cancer. 123:1817–1827. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Gravante G, Overton J, Sorge R, Bhardwaj N, Metcalfe MS, Lloyd DM and Dennison AR: Radiofrequency ablation versus resection for liver tumors: An evidence-based approach to retrospective compartive studies. J Gastrointest Surg. 15:378–387. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Guo W, He X, Li Z and Li Y: Combination of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) vs. Surgical resection (SR) on survival outcome of early hepatocellular carcinoma: A meta-analysis. Hepatogastroenterology. 62:710–714. 2015.PubMed/NCBI

55 

Mathurin P, Raynard B, Dharancy S, Kirzin S, Fallik D, Pruvot FR, Roumilhac D, Canva V, Paris JC, Chaput JC and Naveau S: Meta-analysis: Evaluation of adjuvant therapy after curative liver resection for hepatocellular carcinoma. Aliment Pharmacol Ther. 17:1247–1261. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li JK, Liu XH, Cui H and Xie XH: Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis. Mol Clin Oncol 12: 15-22, 2020.
APA
Li, J., Liu, X., Cui, H., & Xie, X. (2020). Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 12, 15-22. https://doi.org/10.3892/mco.2019.1941
MLA
Li, J., Liu, X., Cui, H., Xie, X."Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12.1 (2020): 15-22.
Chicago
Li, J., Liu, X., Cui, H., Xie, X."Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12, no. 1 (2020): 15-22. https://doi.org/10.3892/mco.2019.1941
Copy and paste a formatted citation
x
Spandidos Publications style
Li JK, Liu XH, Cui H and Xie XH: Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis. Mol Clin Oncol 12: 15-22, 2020.
APA
Li, J., Liu, X., Cui, H., & Xie, X. (2020). Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 12, 15-22. https://doi.org/10.3892/mco.2019.1941
MLA
Li, J., Liu, X., Cui, H., Xie, X."Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12.1 (2020): 15-22.
Chicago
Li, J., Liu, X., Cui, H., Xie, X."Radiofrequency ablation vs. surgical resection for resectable hepatocellular carcinoma: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12, no. 1 (2020): 15-22. https://doi.org/10.3892/mco.2019.1941
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team