Venous thromboembolism and gastrointestinal stromal tumour: A rare association

Galeano‑Valle,Francisco; Del‑Toro‑Cervera,Jorge; Demelo‑Rodriguez,Pablo

doi:10.3892/mco.2019.1942

January-2020 Volume 12 Issue 1

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January-2020 Volume 12 Issue 1

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Article

Venous thromboembolism and gastrointestinal stromal tumour: A rare association

Authors:
- Francisco Galeano‑Valle
- Jorge Del‑Toro‑Cervera
- Pablo Demelo‑Rodriguez
View Affiliations / Copyright

Affiliations: Venous Thromboembolism Unit, Internal Medicine Department, University Hospital Gregorio Marañón, Madrid 28007, Spain
Pages: 57-59
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Published online on: October 31, 2019

https://doi.org/10.3892/mco.2019.1942
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Abstract

Gastrointestinal stromal tumours (GISTs) comprise 0.1‑3% of all gastrointestinal malignancies and represent the majority of gastrointestinal mesenchymal neoplasms. The major cause of GIST is an abnormal form of tyrosine kinase protein. GISTs may arise anywhere in the gastrointestinal tract, but are more commonly encountered in the stomach and small intestine. Gastrointestinal bleeding and abdominal pain are the most frequent symptoms associated with gastric GISTs. However, venous thromboembolism (VTE) is an uncommon presentation of these tumours. To the best of our knowledge, only 4 cases highlighting the association between these rare tumours and VTE have been reported in the literature to date. We herein report a case of a gastric GIST presenting with pulmonary embolism. Current guidelines recommend anticoagulation with low‑molecular‑weight heparin as first‑line treatment for the acute phase of cancer‑associated thrombosis. Prolonged anticoagulation should be considered for an indefinite time period, or until curative treatment. In the present case, tumour resection enabled a reduction in the duration of the anticoagulation treatment, thereby reducing the risk of long‑term bleeding complications.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Venous thromboembolism and gastrointestinal stromal tumour: A rare association

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Abstract

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