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Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy

  • Authors:
    • Naotake Funamizu
    • Yukio Nakabayashi
    • Kazunao Kurihara
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Surgery, Kawaguchi Municipal Medical Center, Kawaguchi, Saitama 333‑0833, Japan
    Copyright: © Funamizu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 134-137
    |
    Published online on: December 6, 2019
       https://doi.org/10.3892/mco.2019.1960
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Abstract

Postoperative pancreatic fistula (POPF) is a common complication following pancreatic resection. It leads to increased medical costs, and longer hospital stays. However, the risk factors of POPF are still unclear, and therefore, this urgent clinical issue should be resolved. The geriatric nutritional risk index (GNRI) is tool to assess the nutritional status using body weight, and serum albumin value, particularly in elderly patients. On the other hand, POPF is associated with body mass index (BMI). Thus, the present study aimed to investigate whether GNRI can predict the risk of POPF in patients after distal pancreatectomy (DP). We conducted a retrospective cohort study involving 37 patients who were treated at the Department of Digestive Surgery, Kawaguchi Municipal Medical Center between January 2007 and June 2018. All patients were subjected to nutritional screening using GNRI, and were followed up after DP for postoperative complications including POPF. In addition, risk factors of POPF, and patient's height, BMI, and preoperative laboratory values were analyzed. POPF was observed in 7 of the 37 (19%) patients. Those with a POPF had significantly lower GNRI values than those without POPF (P<0.001). Receiver operating characteristic curve analysis was performed to determine a cut‑off value of GNRI, which indicated an increased risk of POPF. This value was determined as 96 (sensitivity: 71.4%, specificity: 86.7%, likelihood ratio: 5.36). Univariate analysis confirmed that a GNRI of <96 was significantly associated with POPF (P=0.005), and a multivariate logistic regression analysis revealed that a GNRI of <96 was significant independent predictor of POPF (P=0.005), suggesting its utility for assessing the risk of POPF following DP.
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1 

Parikh PY and Lillemoe KD: Surgical management of pancreatic cancer-distal pancreatectomy. Semin Oncol. 42:110–122. 2015.PubMed/NCBI View Article : Google Scholar

2 

van Hilst J, de Pastena M, de Rooij T, Alseidi A, Busch OR, van Dieren S, van Eijck CH, Giovinazzo F, Groot Koerkamp B, Marchegiani G, et al: Clinical impact of the updated international postoperative pancreatic fistula definition in distal pancreatectomy. HPB (Oxford). 20:1044–1050. 2018.PubMed/NCBI View Article : Google Scholar

3 

Diener MK, Knaebel HP, Witte ST, Rossion I, Kieser M, Buchler MW and Seiler CM: DISPACT Trial Group. DISPACT trial: A randomized controlled trial to compare two different surgical techniques of DIStal PAnCreaTectomy-study rationale and design. Clin Trials. 5:534–545. 2008.PubMed/NCBI View Article : Google Scholar

4 

Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, Tomazic A, Bruns CJ, Busch OR, Farkas S, et al: Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): A randomised, controlled multicentre trial. Lancet. 377:1514–1522. 2011.PubMed/NCBI View Article : Google Scholar

5 

Peng YP, Zhu XL, Yin LD, Zhu Y, Wei JS, Wu JL and Miao Y: Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: A systematic review and meta-analysis. Sci Rep. 7(185)2017.PubMed/NCBI View Article : Google Scholar

6 

Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent JP, Nicolis I, Benazeth S, Cynober L and Aussel C: Geriatric nutritional risk index: A new index for evaluating at-risk elderly medical patients. Am J Clin Nutr. 82:777–783. 2005.PubMed/NCBI View Article : Google Scholar

7 

Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W and Buchler M: International Study Group on Pancreatic Fistula Definition. Postoperative pancreatic fistula: An international study group (ISGPF) definition. Surgery. 138:8–13. 2005.PubMed/NCBI View Article : Google Scholar

8 

Goh BK, Tan YM Chung YF, Cheow PC, Ong HS, Chan WH, Chow PK, Soo KC, Wong WK and Ooi LL: Critical appraisal of 232 consecutive distal pancreatectomies with emphasis on risk factors, outcome, and management of the postoperative pancreatic fistula: A 21-year experience at a single institution. Arch Surg. 143:956–965. 2008.PubMed/NCBI View Article : Google Scholar

9 

Felix K, Schuck A, Gaida MM, Hinz U, Dovzhanskiy D and Werner J: Objective parameters aid the prediction of fistulas in pancreatic surgery. Exp Ther Med. 8:719–726. 2014.PubMed/NCBI View Article : Google Scholar

10 

Kimura W, Miyata H, Gotoh M, Hirai I, Kenjo A, Kitagawa Y, Shimada M, Baba H, Tomita N, Nakagoe T, et al: A pancreaticoduodenectomy risk model derived from 8575 cases from a national single-race population (Japanese) using a web-based data entry system: The 30-day and in-hospital mortality rates for pancreaticoduodenectomy. Ann Surg. 259:773–780. 2014.PubMed/NCBI View Article : Google Scholar

11 

Sell NM, Pucci MJ, Gabale S, Leiby BE, Rosato EL, Winter JM, Yeo CJ and Lavu H: The influence of transection site on the development of pancreatic fistula in patients undergoing distal pancreatectomy: A review of 294 consecutive cases. Surgery. 157:1080–1087. 2015.PubMed/NCBI View Article : Google Scholar

12 

Kalantar-Zadeh K, Kopple JD, Block G and Humphreys MH: A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis. 38:1251–1263. 2001.PubMed/NCBI View Article : Google Scholar

13 

Adejumo OL, Koelling TM and Hummel SL: Nutritional risk index predicts mortality in hospitalized advanced heart failure patients. J Heart Lung Transplant. 34:1385–1389. 2015.PubMed/NCBI View Article : Google Scholar

14 

Hu Q, Wang G, Ren J, Ren H, Li G, Wu X, Gu G, Li R, Guo K, Deng Y, et al: Preoperative prognostic nutritional index predicts postoperative surgical site infections in gastrointestinal fistula patients undergoing bowel resections. Medicine (Baltimore). 95(e4084)2016.PubMed/NCBI View Article : Google Scholar

15 

Funamizu N, Nakabayashi Y, Iida T and Kurihara K: Geriatric nutritional risk index predicts surgical site infection after pancreaticoduodenectomy. Mol Clin Oncol. 9:274–278. 2018.PubMed/NCBI View Article : Google Scholar

16 

Sierzega M, Niekowal B, Kulig J and Popiela T: Nutritional status affects the rate of pancreatic fistula after distal pancreatectomy: A multivariate analysis of 132 patients. J Am Coll Surg. 205:52–59. 2007.PubMed/NCBI View Article : Google Scholar

17 

Parikh JA, Beane JD, Kilbane EM, Milgrom DP and Pitt HA: Is American college of surgeons NSQIP organ space infection a surrogate for pancreatic fistula? J Am Coll Surg. 219:1111–1116. 2014.PubMed/NCBI View Article : Google Scholar

18 

Sato N, Mori Y, Minagawa N, Tamura T, Shibao K, Higure A and Yamaguchi K: Rapid postoperative reduction in prognostic nutrition index is associated with the development of pancreatic fistula following distal pancreatectomy. Pancreatology. 14:216–220. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Funamizu N, Nakabayashi Y and Kurihara K: Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy. Mol Clin Oncol 12: 134-137, 2020.
APA
Funamizu, N., Nakabayashi, Y., & Kurihara , K. (2020). Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy. Molecular and Clinical Oncology, 12, 134-137. https://doi.org/10.3892/mco.2019.1960
MLA
Funamizu, N., Nakabayashi, Y., Kurihara , K."Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy". Molecular and Clinical Oncology 12.2 (2020): 134-137.
Chicago
Funamizu, N., Nakabayashi, Y., Kurihara , K."Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy". Molecular and Clinical Oncology 12, no. 2 (2020): 134-137. https://doi.org/10.3892/mco.2019.1960
Copy and paste a formatted citation
x
Spandidos Publications style
Funamizu N, Nakabayashi Y and Kurihara K: Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy. Mol Clin Oncol 12: 134-137, 2020.
APA
Funamizu, N., Nakabayashi, Y., & Kurihara , K. (2020). Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy. Molecular and Clinical Oncology, 12, 134-137. https://doi.org/10.3892/mco.2019.1960
MLA
Funamizu, N., Nakabayashi, Y., Kurihara , K."Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy". Molecular and Clinical Oncology 12.2 (2020): 134-137.
Chicago
Funamizu, N., Nakabayashi, Y., Kurihara , K."Lower geriatric nutritional risk index predicts postoperative pancreatic fistula in patients with distal pancreatectomy". Molecular and Clinical Oncology 12, no. 2 (2020): 134-137. https://doi.org/10.3892/mco.2019.1960
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