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Case Report Open Access

Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report

  • Authors:
    • Tetsuya Ogawa
    • Shusa Ohshika
    • Michiro Yanagisawa
    • Akira Kurose
    • Yasuyuki Ishibashi
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
    Copyright: © Ogawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 144-147
    |
    Published online on: December 16, 2019
       https://doi.org/10.3892/mco.2019.1966
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Abstract

The present report describes a case in which teriparatide, which is widely used to treat osteoporosis, may have accelerated the growth of an undiagnosed pre‑existing bone tumor of the femur. A 76‑year‑old woman visited hospital with pain in the right thigh after falling from a ladder. A non‑pathological femoral shaft fracture was diagnosed by plain radiography. There were no findings of pathological fracture on the examination. In addition, the patient underwent intramedullary femoral nail fixation and started teriparatide treatment for osteoporosis. The teriparatide was discontinued after 2 months due to nausea. A total of 6 months after surgery, the woman visited Hirosaki University Hospital with abnormal swelling of the right thigh. Following a diagnosis of high‑grade malignant mesenchymal bone tumor by needle biopsy, the patient underwent right hip disarticulation. Pathological examination provided a definitive diagnosis of osteoblastic osteosarcoma. The present case is a reminder that teriparatide may accelerate the growth of a pre‑existing malignant tumor and that fractures, particularly in elderly patients, should be screened for pathological fracture prior to administering teriparatide.
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Copy and paste a formatted citation
Spandidos Publications style
Ogawa T, Ohshika S, Yanagisawa M, Kurose A and Ishibashi Y: Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report. Mol Clin Oncol 12: 144-147, 2020.
APA
Ogawa, T., Ohshika, S., Yanagisawa, M., Kurose, A., & Ishibashi, Y. (2020). Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report. Molecular and Clinical Oncology, 12, 144-147. https://doi.org/10.3892/mco.2019.1966
MLA
Ogawa, T., Ohshika, S., Yanagisawa, M., Kurose, A., Ishibashi, Y."Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report". Molecular and Clinical Oncology 12.2 (2020): 144-147.
Chicago
Ogawa, T., Ohshika, S., Yanagisawa, M., Kurose, A., Ishibashi, Y."Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report". Molecular and Clinical Oncology 12, no. 2 (2020): 144-147. https://doi.org/10.3892/mco.2019.1966
Copy and paste a formatted citation
x
Spandidos Publications style
Ogawa T, Ohshika S, Yanagisawa M, Kurose A and Ishibashi Y: Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report. Mol Clin Oncol 12: 144-147, 2020.
APA
Ogawa, T., Ohshika, S., Yanagisawa, M., Kurose, A., & Ishibashi, Y. (2020). Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report. Molecular and Clinical Oncology, 12, 144-147. https://doi.org/10.3892/mco.2019.1966
MLA
Ogawa, T., Ohshika, S., Yanagisawa, M., Kurose, A., Ishibashi, Y."Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report". Molecular and Clinical Oncology 12.2 (2020): 144-147.
Chicago
Ogawa, T., Ohshika, S., Yanagisawa, M., Kurose, A., Ishibashi, Y."Teriparatide may accelerate the growth of a pre‑existing malignant tumor in an elderly patient with osteoporosis: A case report". Molecular and Clinical Oncology 12, no. 2 (2020): 144-147. https://doi.org/10.3892/mco.2019.1966
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