Significance of a preoperative tumor marker gradient for predicting microvascular invasion in cases of hepatocellular carcinoma

Koizumi,Satoshi; Yamashita,Shingo; Matsumura,Satoshi; Takeda,Kazuhisa; Minagawa,Takuya; Kobayashi,Shinjiro; Hibi,Taizo; Shinoda,Masahiro; Endo,Itaru; Tanabe,Minoru; Yamamoto,Masakazu; Otsubo,Takehito

doi:10.3892/mco.2020.1975

March-2020 Volume 12 Issue 3

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March-2020 Volume 12 Issue 3

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Article

Significance of a preoperative tumor marker gradient for predicting microvascular invasion in cases of hepatocellular carcinoma

Authors:
- Satoshi Koizumi
- Shingo Yamashita
- Satoshi Matsumura
- Kazuhisa Takeda
- Takuya Minagawa
- Shinjiro Kobayashi
- Taizo Hibi
- Masahiro Shinoda
- Itaru Endo
- Minoru Tanabe
- Masakazu Yamamoto
- Takehito Otsubo
View Affiliations / Copyright

Affiliations: Division of Gastroenterological and General Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216‑8511, Japan, Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan, Department of Hepatobiliary and Pancreatic Surgery, Tokyo Medical and Dental University, Tokyo 113‑8519, Japan, Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Yokohama 236‑0004, Japan, Department of Surgery, School of Medicine, Keio University, Tokyo 160‑8582, Japan
Pages: 290-294
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Published online on: January 10, 2020

https://doi.org/10.3892/mco.2020.1975
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Abstract

Although vascular invasion is an important factor in the progression and treatment of hepatocellular carcinoma (HCC), it remains difficult to determine, on the basis of preoperative imaging alone, whether vascular invasion, especially microvascular invasion, has occurred. The current retrospective study enrolled 292 patients who, between 2004 and 2014, underwent curative hepatectomy as an initial treatment for HCC. The patients were divided between those with (n=70) and those without (n=222) microvascular invasion. Whether tumor‑marker‑based prediction of microvascular invasion was possible was assessed by comparing the preoperative serum α‑fetoprotein (AFP) and prothrombin induced by vitamin K absence or antagonist‑II concentrations between two groups of patients. The AFP concentration was significantly higher in patients with microvascular invasion compared with patients without microvascular invasion (P=0.0019). Stepwise logistic regression analysis demonstrated the AFP concentration and the logarithmic conversion ratio of the AFP gradient (log AFP grad) to be useful (P=0.0019; 0.0424) for predicting microvascular invasion. The serum AFP concentration and log AFP grad appear to be clinically useful in predicting microvascular invasion in patients with HCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significance of a preoperative tumor marker gradient for predicting microvascular invasion in cases of hepatocellular carcinoma

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