Open Access

Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy

  • Authors:
    • Lili Wang
    • Yongzhi Miao
    • Tianwen Chen
    • Dengzhong Sun
    • Sitang Ge
    • Lugen Zuo
    • Mulin Liu
  • View Affiliations

  • Published online on: January 17, 2020     https://doi.org/10.3892/mco.2020.1980
  • Pages: 196-201
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preoperative prognostic nutritional index (PNI) has been widely used for the clinical evaluation of patients with cancer. The present study assessed the prognostic value of preoperative PNI in patients after gastric cancer (GC) radical surgery. The clinical case and follow‑up data of 170 patients undergoing GC radical surgery were retrospectively analyzed. The receiver operating characteristic (ROC) curve was used to compare the predictive ability of each inflammatory index: The PNI, neutrophil‑to‑lymphocyte ratio (NLR) and lymphocyte‑to‑monocyte ratio (LMR). The correlation between the preoperative PNI and overall survival (OS) was also analyzed via Kaplan‑Meier (K‑M) curves and multivariate Cox regression analyses. The results revealed that the optimal PNI cut-off was 46.030. According to this cut-off value, the whole sample was divided into PNI <46.030 (low PNI group) and PNI ≥46.030 (high PNI group). These groups were comprised of 102 and 68 cases, respectively. The area under the curve value of the PNI was 0.725, which was greater than that of traditional inflammatory indices, including the NLR and LMR. K‑M survival analysis revealed that the 5 year survival rate of patients in the low PNI group was significantly lower than that of patients in the high PNI group (P<0.01). Univariate analysis and Cox multiple regression model analysis demonstrated that the T stage, N stage, pathological grade and PNI were independent risk factors for the 5 year survival rate after radical gastrectomy (P<0.05). In conclusion, the preoperative PNI is an independent risk factor for 5 year survival after radical gastrectomy and has clinical value for the prognostic evaluation of patients with GC.
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March 2020
Volume 12 Issue 3

Print ISSN: 2049-9450
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APA
Wang, L., Miao, Y., Chen, T., Sun, D., Ge, S., Zuo, L., & Liu, M. (2020). Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy. Molecular and Clinical Oncology, 12, 196-201. https://doi.org/10.3892/mco.2020.1980
MLA
Wang, L., Miao, Y., Chen, T., Sun, D., Ge, S., Zuo, L., Liu, M."Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy". Molecular and Clinical Oncology 12.3 (2020): 196-201.
Chicago
Wang, L., Miao, Y., Chen, T., Sun, D., Ge, S., Zuo, L., Liu, M."Value of the preoperative prognostic nutritional index for the evaluation of patient prognosis after radical gastrectomy". Molecular and Clinical Oncology 12, no. 3 (2020): 196-201. https://doi.org/10.3892/mco.2020.1980