Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
March-2020 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2020 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Small early gastric cancer with synchronous bone metastasis: A case report

  • Authors:
    • Isao Fujita
    • Tatsuya Toyokawa
    • Takafumi Makino
    • Katsunori Matsueda
    • Shizuma Omote
    • Joichiro Horii
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, National Hospital Organization, Fukuyama Medical Center, Fukuyama, Hiroshima 720‑8520, Japan
    Copyright: © Fujita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 202-207
    |
    Published online on: January 22, 2020
       https://doi.org/10.3892/mco.2020.1985
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bone metastasis during the early stages of gastric cancer is rare, and synchronous bone metastasis is even less common. The present report outlines a case of a small early gastric cancer, which was detected due to bone metastasis. A 63‑year‑old man was referred to Fukuyama Medical Center with back pain and anorexia of 2 weeks' evolution. MRI revealed multiple metastatic lesions in the thoracic and spinal bone. Fluorodeoxyglucose positron emission tomography revealed focal uptake in the lesser curvature of the stomach and in the spinal bone, pelvic and thigh bone, but uptake was not detected in the stomach. Esophagogastroduodenoscopy revealed a 10 mm slightly elevated lesion with a central depression in the middle‑third of the stomach. Endoscopic ultrasonography confirmed that the tumor was confined to the mucosa. A biopsy specimen acquired from the gastric lesion indicated signet‑ring cell carcinoma, and the specimen acquired from the lumbar spine revealed cell aggregation such as that found in signet‑ring cell carcinoma. The patient received first‑line chemotherapy with S‑1 and cisplatin, and second‑line chemotherapy with nab‑paclitaxel. However, the patient died 120 days after consultation at Fukuyama Medical Center.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Japanese Gastric Cancer Association: Japanese Classification of Gastric Carcinoma. 3rd English edition. Gastric Cancer. 14:101–112. 2011.

2 

Shiraishi N, Inomata M, Osawa N, Yasuda K, Adachi Y and Kitano S: Early and late recurrence after gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer. 89:255–261. 2000.PubMed/NCBI View Article : Google Scholar

3 

Nakajima T: Gastric cancer treatment guidelines in Japan. Gastric Cancer. 5:1–5. 2002.PubMed/NCBI View Article : Google Scholar

4 

Santoro E, Garofalo A, Scutari FA, Carlini M, Zanarini T and Santoro E: Multicenter retrospective study of 3,024 patients operated on for stomach cancer in Italy. Epidemiology, surgical treatment and survival. Ann Gastroenterol Hepatol (Paris). 27:167–171. 1991.(In French). PubMed/NCBI

5 

Park JM, Song KY, O JH, Kim WC, Choi MG and Park CH: Bone recurrence after curative resection of gastric cancer. Gastric Cancer. 16:362–369. 2013.PubMed/NCBI View Article : Google Scholar

6 

Shimada H, Okazumi S, Koyama M and Murakami K: Japanese gastric cancer association task force for research promotion: Clinical utility of 18F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature. Gastric Cancer. 14:13–21. 2011.PubMed/NCBI View Article : Google Scholar

7 

Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2014 (Ver.4). Gastric Cancer. 20:1–19. 2017.

8 

Yoshikawa K and Kitaoka H: Bone metastasis of gastric cancer. Jpn J Surg. 13:173–176. 1983.PubMed/NCBI View Article : Google Scholar

9 

Choi CW, Lee DS, Chung JK, Lee MC, Kim NK, Choi KW and Koh CS: Evaluation of bone metastasis by Tc-99m MDP imaging in patients with stomach cancer. Clin Nucl Med. 20:310–314. 1995.PubMed/NCBI View Article : Google Scholar

10 

Mori W, Adachi Y, Okabe H and Oota K: An analysis of 755 autopsied cases of malignant tumors. A statistical study of their metastasis. Gan No Rinsho. 9:351–374. 1963.(In Japanese).

11 

Kobayashi M, Okabayashi T, Sano T and Araki K: Metastatic bone cancer as a recurrence of early gastric cancer-characteristics and possible mechanisms. World J Gastroenterol. 11:5587–5591. 2005.PubMed/NCBI View Article : Google Scholar

12 

Gurzu S, Jung I and Kadar Z: Aberrant metastatic behavior and particular features of early gastric cancer. APMIS. 123:999–1006. 2015.PubMed/NCBI View Article : Google Scholar

13 

Dassen AE, Lips DJ, Hoekstra CJ, Pruijt JFM and Bosscha K: FDG-PET has no definite role in preoperative imaging in gastric cancer. Eur J Surg Oncol. 35:449–455. 2009.PubMed/NCBI View Article : Google Scholar

14 

Kawamura T, Kusakabe T, Sugino T, Watanabe K, Fukuda T, Nashimoto A, Honma K and Suzuki T: Expression of glucose transporter-1 in human gastric carcinoma: Association with tumor aggressiveness, metastasis, and patient survival. Cancer. 92:634–641. 2001.PubMed/NCBI View Article : Google Scholar

15 

Yamada A, Oguchi K, Fukushima M, Imai Y and Kadoya M: Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography in gastric carcinoma: Relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression. Ann Nucl Med. 20:597–604. 2006.PubMed/NCBI View Article : Google Scholar

16 

Alakus H, Batur M, Schmidt M, Drebber U, Baldus SE, Vallböhmer D, Prenzel KL, Metzger R, Bollschweiler E, Hölscher AH and Mönig S: Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression. Nucl Med Commun. 31:532–538. 2010.PubMed/NCBI View Article : Google Scholar

17 

Yoshioka T, Yamaguchi K, Kubota K, Saginoya T, Yamazaki T, Ido T, Yamaura G, Takahashi H, Fukuda H and Kanamaru R: Evaluation of 18F-FDG PET in patients with advanced, metastatic, or recurrent gastric cancer. J Nucl Med. 44:690–699. 2003.PubMed/NCBI

18 

Ma DW, Kim JH, Jeon TJ, Lee YC, Yun M, Youn YH, Park H and Lee SI: 18F-fluorodeoxyglucose positron emission tomography-computed tomography for the evaluation of bone metastasis in patients with gastric cancer. Dig Liver Dis. 45:769–775. 2013.PubMed/NCBI View Article : Google Scholar

19 

Kawanaka Y, Kitajima K, Fukushima K, Mouri M, Doi H, Oshima T, Niwa H, Kaibe N, Sasako M, Tomita T, et al: Added value of pretreatment (18)F-FDG PET/CT for staging of advanced gastric cancer: Comparison with contrast-enhanced MDCT. Eur J Radiol. 85:989–995. 2016.PubMed/NCBI View Article : Google Scholar

20 

Kang SH, Kim JI, Moon HS, Kang HM, Kim SH, Seong JK, Lee BS, Jeong HY, Song KS, Noh SM, et al: Overt bone marrow metastasis from early gastric cancer. Endoscopy. 40:E34–E35. 2008.PubMed/NCBI View Article : Google Scholar

21 

Hironaka SI, Boku N, Ohtsu A, Nagashima F, Sano Y, Muto M, Fujii T, Tajiri H and Yoshida S: Sequential methotrexate and 5-fluorouracil therapy for gastric cancer patients with bone metastasis. Gastric Cancer. 3:19–23. 2000.PubMed/NCBI View Article : Google Scholar

22 

Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, Miyashita K, Nishizaki T, Kobayashi O, Takiyama W, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A phase III trial. Lancet Oncol. 9:215–221. 2008.PubMed/NCBI View Article : Google Scholar

23 

Sasaki Y, Nishina T, Yasui H, Goto M, Muro K, Tsuji A, Koizumi W, Toh Y, Hara T and Miyata Y: Phase II trial of nanoparticle albumin-bound paclitaxel as second-line chemotherapy for unresectable or recurrent gastric cancer. Cancer Sci. 105:812–817. 2014.PubMed/NCBI View Article : Google Scholar

24 

Shitara K, Takashima A, Fujitani K, Koeda K, Hara H, Nakayama N, Hironaka S, Nishikawa K, Makari Y, Amagai K, et al: Nab-paclitaxel versus solvent-based paclitaxel in patients with previously treated advanced gastric cancer (ABSOLUTE): An open-label, randomised, non-inferiority, phase 3 trial. Lancet Gastroenterol Hepatol. 2:277–287. 2017.PubMed/NCBI View Article : Google Scholar

25 

Wilke H, Muro K, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, Hironaka S, Sugimoto N, Lipatov O, Kim TY, et al: Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): A double-blind, randomised phase 3 trial. Lancet Oncol. 15:1224–1235. 2014.PubMed/NCBI View Article : Google Scholar

26 

Woo Y, Fujisaki S, Takashina M, Tomita R, Sakurai K and Takayama T: A case of metastases to the bone, skin, and ovary from gastric cancer occurring more than eight years after distal gastrectomy. Gan To Kagaku Ryoho. 44:1571–1573. 2017.(In Japanese). PubMed/NCBI

27 

Takishita C, Yajima K, Iwasaki Y, Ohashi M, Iwanaga T and Oohinata R: A case of early gastric cancer with multiple synchronous bone metastases treated complete response with S-1+CDDP. Gan To Kagaku Ryoho. 41:2611–2614. 2014.(In Japanese). PubMed/NCBI

28 

Choi YJ, Kim DH, Han HS, Han JH, Son SM, Kim DS and Yun HY: Long-term survival after gastrectomy and metastasectomy for gastric cancer with synchronous bone metastasis. World J Gastroenterol. 24:150–156. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fujita I, Toyokawa T, Makino T, Matsueda K, Omote S and Horii J: Small early gastric cancer with synchronous bone metastasis: A case report. Mol Clin Oncol 12: 202-207, 2020.
APA
Fujita, I., Toyokawa, T., Makino, T., Matsueda, K., Omote, S., & Horii, J. (2020). Small early gastric cancer with synchronous bone metastasis: A case report. Molecular and Clinical Oncology, 12, 202-207. https://doi.org/10.3892/mco.2020.1985
MLA
Fujita, I., Toyokawa, T., Makino, T., Matsueda, K., Omote, S., Horii, J."Small early gastric cancer with synchronous bone metastasis: A case report". Molecular and Clinical Oncology 12.3 (2020): 202-207.
Chicago
Fujita, I., Toyokawa, T., Makino, T., Matsueda, K., Omote, S., Horii, J."Small early gastric cancer with synchronous bone metastasis: A case report". Molecular and Clinical Oncology 12, no. 3 (2020): 202-207. https://doi.org/10.3892/mco.2020.1985
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita I, Toyokawa T, Makino T, Matsueda K, Omote S and Horii J: Small early gastric cancer with synchronous bone metastasis: A case report. Mol Clin Oncol 12: 202-207, 2020.
APA
Fujita, I., Toyokawa, T., Makino, T., Matsueda, K., Omote, S., & Horii, J. (2020). Small early gastric cancer with synchronous bone metastasis: A case report. Molecular and Clinical Oncology, 12, 202-207. https://doi.org/10.3892/mco.2020.1985
MLA
Fujita, I., Toyokawa, T., Makino, T., Matsueda, K., Omote, S., Horii, J."Small early gastric cancer with synchronous bone metastasis: A case report". Molecular and Clinical Oncology 12.3 (2020): 202-207.
Chicago
Fujita, I., Toyokawa, T., Makino, T., Matsueda, K., Omote, S., Horii, J."Small early gastric cancer with synchronous bone metastasis: A case report". Molecular and Clinical Oncology 12, no. 3 (2020): 202-207. https://doi.org/10.3892/mco.2020.1985
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team