Open Access

Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis

  • Authors:
    • Prithvi Singh
    • Arpita Rai
    • Ravins Dohare
    • Shweta Arora
    • Sher Ali
    • Shama Parveen
    • Mansoor Ali Syed
  • View Affiliations

  • Published online on: January 30, 2020     https://doi.org/10.3892/mco.2020.1991
  • Pages: 299-310
  • Copyright: © Singh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The molecular mechanism of oral submucous fibrosis (OSF) is yet to be fully elucidated. The identification of reliable signature genes to screen patients with a high risk of OSF and to provide oral cancer surveillance is therefore required. The present study produced a filtering criterion based on network characteristics and principal component analysis, and identified the genes that were involved in OSF prognosis. Two gene expression datasets were analyzed using meta‑analysis, the results of which revealed 1,176 biologically significant genes. A co‑expression network was subsequently constructed and weighted gene modules were detected. The pathway and functional enrichment analyses of the present study allowed for the identification of modules 1 and 2, and their respective genes, SPARC (osteonectin), cwcv and kazal like domain proteoglycan 1 (SPOCK1) and kruppel like factor 6 (KLF6), which were involved in the occurrence of OSF. The results revealed that both genes had a prominent role in epithelial to mesenchymal transition during OSF progression. The genes identified in the present study require further exploration and validation within clinical settings to determine their roles in OSF.
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April-2020
Volume 12 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Singh P, Rai A, Dohare R, Arora S, Ali S, Parveen S and Syed MA: Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis. Mol Clin Oncol 12: 299-310, 2020
APA
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., & Syed, M.A. (2020). Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis. Molecular and Clinical Oncology, 12, 299-310. https://doi.org/10.3892/mco.2020.1991
MLA
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., Syed, M. A."Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis". Molecular and Clinical Oncology 12.4 (2020): 299-310.
Chicago
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., Syed, M. A."Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis". Molecular and Clinical Oncology 12, no. 4 (2020): 299-310. https://doi.org/10.3892/mco.2020.1991