Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
April-2020 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2020 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis

  • Authors:
    • Prithvi Singh
    • Arpita Rai
    • Ravins Dohare
    • Shweta Arora
    • Sher Ali
    • Shama Parveen
    • Mansoor Ali Syed
  • View Affiliations / Copyright

    Affiliations: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India, Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi 110025, India
    Copyright: © Singh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 299-310
    |
    Published online on: January 30, 2020
       https://doi.org/10.3892/mco.2020.1991
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The molecular mechanism of oral submucous fibrosis (OSF) is yet to be fully elucidated. The identification of reliable signature genes to screen patients with a high risk of OSF and to provide oral cancer surveillance is therefore required. The present study produced a filtering criterion based on network characteristics and principal component analysis, and identified the genes that were involved in OSF prognosis. Two gene expression datasets were analyzed using meta‑analysis, the results of which revealed 1,176 biologically significant genes. A co‑expression network was subsequently constructed and weighted gene modules were detected. The pathway and functional enrichment analyses of the present study allowed for the identification of modules 1 and 2, and their respective genes, SPARC (osteonectin), cwcv and kazal like domain proteoglycan 1 (SPOCK1) and kruppel like factor 6 (KLF6), which were involved in the occurrence of OSF. The results revealed that both genes had a prominent role in epithelial to mesenchymal transition during OSF progression. The genes identified in the present study require further exploration and validation within clinical settings to determine their roles in OSF.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Bari S, Metgud R, Vyas Z and Tak A: An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis. J Cancer Res Ther. 13:399–405. 2017.PubMed/NCBI View Article : Google Scholar

2 

Ray JG, Ranganathan K and Chattopadhyay A: Malignant transformation of oral submucous fibrosis: Overview of histopathological aspects. Oral Surg Oral Med Oral Pathol Oral Radiol. 122:200–209. 2016.PubMed/NCBI View Article : Google Scholar

3 

Ekanayaka RP and Tilakaratne WM: Oral submucous fibrosis: Review on mechanisms of pathogenesis and malignant transformation. J Carcinog Mutagen, 2013. Available from: https://www.omicsonline.org/oral-submucous-fibrosis-a-clinico-histopathological-comparative-study-in-population-of-southern-rajasthan-2157-2518-S5-002.php?aid=19130.

4 

Prabhu RV, Prabhu V, Chatra L, Shenai P, Suvarna N and Dandekeri S: Areca nut and its role in oral submucous fibrosis. J Clin Exp Dent. 6:e569–e575. 2014.PubMed/NCBI View Article : Google Scholar

5 

Wollina U, Verma SB, Ali FM and Patil K: Oral submucous fibrosis: An update. Clin Cosmet Investig Dermatol. 8:193–204. 2015.PubMed/NCBI View Article : Google Scholar

6 

Khan I, Kumar N, Pant I, Narra S and Kondaiah P: Activation of TGF-β pathway by areca nut constituents: A possible cause of oral submucous fibrosis. PLoS One. 7(e51806)2012.PubMed/NCBI View Article : Google Scholar

7 

Yang SF, Wang YH, Su NY, Yu HC, Wei CY, Yu CH and Chang YC: Changes in prevalence of precancerous oral submucous fibrosis from 1996 to 2013 in Taiwan: A nationwide population-based retrospective study. J Formos Med Assoc. 117:147–152. 2018.PubMed/NCBI View Article : Google Scholar

8 

Ramasamy A, Mondry A, Holmes CC and Altman DG: Key issues in conducting a meta-analysis of gene expression microarray datasets. PLoS Med. 5(e184)2008.PubMed/NCBI View Article : Google Scholar

9 

Ruan J, Dean AK and Zhang W: A general co-expression network-based approach to gene expression analysis: Comparison and applications. BMC Syst Biol. 4(8)2010.PubMed/NCBI View Article : Google Scholar

10 

Wang LX, Li Y and Chen GZ: Network-based co-expression analysis for exploring the potential diagnostic biomarkers of metastatic melanoma. PLoS One. 13(e0190447)2018.PubMed/NCBI View Article : Google Scholar

11 

Mahapatra S, Mandal B and Swarnkar T: Biological networks integration based on dense module identification for gene prioritization from microarray data. Gene Rep. 12:276–288. 2018. View Article : Google Scholar

12 

Lin T, Zhang B and He H: Identification of genes correlated with oral squamous cell carcinoma. J Cancer Res Ther. 14 (Suppl):S675–S679. 2018.PubMed/NCBI View Article : Google Scholar

13 

Shah SD and Braun R: GeneSurrounder: Network-based identification of disease genes in expression data. BMC Bioinformatics. 20(229)2019.PubMed/NCBI View Article : Google Scholar

14 

Pant I, Kumar N, Khan I, Rao SG and Kondaiah P: Role of areca nut induced TGF-β and epithelial-mesenchymal interaction in the pathogenesis of oral submucous fibrosis. PLoS One. 10(e0129252)2015.PubMed/NCBI View Article : Google Scholar

15 

Clough E and Barrett T: The gene expression omnibus database. Methods Mol Biol. 1418:93–110. 2016.PubMed/NCBI View Article : Google Scholar

16 

Thangaraj SV, Shyamsundar V, Krishnamurthy A, Ramani P, Ganesan K, Muthuswami M and Ramshankar V: Molecular portrait of oral tongue squamous cell carcinoma shown by integrative meta-analysis of expression profiles with validations. PLoS One. 11(e0156582)2016.PubMed/NCBI View Article : Google Scholar

17 

Gray KA, Seal RL, Tweedie S, Wright MW and Bruford EA: A review of the new HGNC gene family resource. Hum Genomics. 10(6)2016.PubMed/NCBI View Article : Google Scholar

18 

Berriz GF and Roth FP: The Synergizer service for translating gene, protein and other biological identifiers. Bioinforma Oxf Engl. 24:2272–2273. 2008.PubMed/NCBI View Article : Google Scholar

19 

Reimand J, Arak T, Adler P, Kolberg L, Reisberg S, Peterson H and Vilo J: g:Profiler-a web server for functional interpretation of gene lists (2016 update). Nucleic Acids Res. 44:W83–W89. 2016.PubMed/NCBI View Article : Google Scholar

20 

Mohammad F, Flight RM, Harrison BJ, Petruska JC and Rouchka EC: AbsIDconvert: An absolute approach for converting genetic identifiers at different granularities. BMC Bioinformatics. 13(229)2012.PubMed/NCBI View Article : Google Scholar

21 

Mudunuri U, Che A, Yi M and Stephens RM: bioDBnet: The biological database network. Bioinformatics. 25:555–556. 2009.PubMed/NCBI View Article : Google Scholar

22 

Huang da W, Sherman BT, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID gene ID conversion tool. Bioinformation. 2:428–430. 2008.PubMed/NCBI View Article : Google Scholar

23 

Phan JH, Young AN and Wang MD: omniBiomarker: A web-based application for knowledge-driven biomarker identification. IEEE Trans Biomed Eng. 60:3364–3367. 2013.PubMed/NCBI View Article : Google Scholar

24 

Maglott D, Ostell J, Pruitt KD and Tatusova T: Entrez gene: Gene-centered information at NCBI. Nucleic Acids Res. 33 (Database Issue):D54–D58. 2005.PubMed/NCBI View Article : Google Scholar

25 

Aken BL, Achuthan P, Akanni W, Amode MR, Bernsdorff F, Bhai J, Billis K, Carvalho-Silva D, Cummins C, Clapham P, et al: Ensembl 2017. Nucleic Acids Res. 45:D635–D642. 2017.PubMed/NCBI View Article : Google Scholar

26 

van Assen MALM, van Aert RC and Wicherts JM: Meta-analysis using effect size distributions of only statistically significant studies. Psychol Methods. 20:293–309. 2015.PubMed/NCBI View Article : Google Scholar

27 

Dalman MR, Deeter A, Nimishakavi G and Duan ZH: Fold change and p-value cutoffs significantly alter microarray interpretations. BMC Bioinformatics. 13 (Suppl 2)(S11)2012.PubMed/NCBI View Article : Google Scholar

28 

Cheadle C, Vawter MP, Freed WJ and Becker KG: Analysis of microarray data using Z score transformation. J Mol Diagn. 5:73–81. 2003.PubMed/NCBI View Article : Google Scholar

29 

Ho KH, Chen PH, Hsi E, Shih CM, Chang WC, Cheng CH, Lin CW and Chen KC: Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis. Sci Rep. 7(732)2017.PubMed/NCBI View Article : Google Scholar

30 

Jeong H, Tombor B, Albert R, Oltvai ZN and Barabási AL: The large-scale organization of metabolic networks. Nature. 407:651–654. 2000.PubMed/NCBI View Article : Google Scholar

31 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9(559)2008.PubMed/NCBI View Article : Google Scholar

32 

Zhang B and Horvath S: A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol. 4(Article17)2005.PubMed/NCBI View Article : Google Scholar

33 

Li X, Dong W, Qu X, Zhao H, Wang S, Hao Y, Li Q, Zhu J, Ye M and Xiao W: Molecular dysexpression in gastric cancer revealed by integrated analysis of transcriptome data. Oncol Lett. 13:3177–3185. 2017.PubMed/NCBI View Article : Google Scholar

34 

Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID Gene Functional Classification Tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8(R183)2007.PubMed/NCBI View Article : Google Scholar

35 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009.PubMed/NCBI View Article : Google Scholar

36 

Chen J, Bardes EE, Aronow BJ and Jegga AG: ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37 (Web Server Issue):W305–W311. 2009.PubMed/NCBI View Article : Google Scholar

37 

Wang J, Vasaikar S, Shi Z, Greer M and Zhang B: WebGestalt 2017: A more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit. Nucleic Acids Res. 45:W130–W137. 2017.PubMed/NCBI View Article : Google Scholar

38 

Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D and Thomas PD: PANTHER version 11: Expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements. Nucleic Acids Res. 45 (D1):D183–D189. 2017.PubMed/NCBI View Article : Google Scholar

39 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017.PubMed/NCBI View Article : Google Scholar

40 

Nishimura D: BioCarta. Biotech Softw Internet Rep. 2:117–120. 2001. View Article : Google Scholar

41 

Fabregat A, Jupe S, Matthews L, Sidiropoulos K, Gillespie M, Garapati P, Haw R, Jassal B, Korninger F, May B, et al: The reactome pathway knowledgebase. Nucleic Acids Res. 46:D649–D655. 2018.PubMed/NCBI View Article : Google Scholar

42 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43 (Database Issue):D447–D452. 2015.PubMed/NCBI View Article : Google Scholar

43 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003.PubMed/NCBI View Article : Google Scholar

44 

Kumar R, Samal SK, Routray S, Dash R and Dixit A: Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry. Sci Rep. 7(2472)2017.PubMed/NCBI View Article : Google Scholar

45 

Alter O, Brown PO and Botstein D: Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci USA. 97:10101–10106. 2000.PubMed/NCBI View Article : Google Scholar

46 

Langfelder P and Horvath S: Eigengene networks for studying the relationships between co-expression modules. BMC Syst Biol. 1(54)2007.PubMed/NCBI View Article : Google Scholar

47 

Pontén F, Gry M, Fagerberg L, Lundberg E, Asplund A, Berglund L, Oksvold P, Björling E, Hober S, Kampf C, et al: A global view of protein expression in human cells, tissues, and organs. Mol Syst Biol. 5(337)2009.PubMed/NCBI View Article : Google Scholar

48 

D'haeseleer P: How does gene expression clustering work? Nat Biotechnol. 23:1499–1501. 2005.PubMed/NCBI View Article : Google Scholar

49 

Alsina L, Israelsson E, Altman MC, Dang KK, Ghandil P, Israel L, von Bernuth H, Baldwin N, Qin H, Jin Z, et al: A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4. Nat Immunol. 15:1134–1142. 2014.PubMed/NCBI View Article : Google Scholar

50 

Shah N, Kumar R and Shah MK: Immunological studies in oral submucous fibrosis. Indian J Dent Res. 5:81–87. 1994.PubMed/NCBI

51 

Canniff JP, Batchelor JR, Dodi IA and Harvey W: HLA-typing in oral submucous fibrosis. Tissue Antigens. 26:138–142. 1985.PubMed/NCBI View Article : Google Scholar

52 

Kiliaridis S, Mahboubi PH, Raadsheer MC and Katsaros C: Ultrasonographic thickness of the masseter muscle in growing individuals with unilateral crossbite. Angle Orthod. 77:607–611. 2007.PubMed/NCBI View Article : Google Scholar

53 

Chawla H, Urs Ab, Augustine J and Kumar P: Characterization of muscle alteration in oral submucous fibrosis-seeking new evidence. Med Oral Patol Oral Cirugia Bucal. 20:e670–e677. 2015.PubMed/NCBI View Article : Google Scholar

54 

Sumathi M, Balaji N and Malathi N: A prospective transmission electron microscopic study of muscle status in oral submucous fibrosis along with retrospective analysis of 80 cases of oral submucous fibrosis. J Oral Maxillofac Pathol. 16:318–324. 2012.PubMed/NCBI View Article : Google Scholar

55 

Rooban T, Saraswathi TR, Al Zainab FHI, Devi U, Eligabeth J and Ranganathan K: A light microscopic study of fibrosis involving muscle in oral submucous fibrosis. Indian J Dent Res. 16:131–134. 2005.PubMed/NCBI View Article : Google Scholar

56 

Sarkar S and Dong A: Community detection in graphs using singular value decomposition. Phys Rev E Stat Nonlin Soft Matter Phys. 83(046114)2011.PubMed/NCBI View Article : Google Scholar

57 

Hsu LS, Huang RH, Lai HW, Hsu HT, Sung WW, Hsieh MJ, Wu CY, Lin YM, Chen MK, Lo YS and Chen CJ: KLF6 inhibited oral cancer migration and invasion via downregulation of mesenchymal markers and inhibition of MMP-9 activities. Int J Med Sci. 14:530–535. 2017.PubMed/NCBI View Article : Google Scholar

58 

Botella LM, Sanz-Rodriguez F, Komi Y, Fernandez-L A, Varela E, Garrido-Martin EM, Narla G, Friedman SL and Kojima S: TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction. Biochem J. 419:485–495. 2009.PubMed/NCBI View Article : Google Scholar

59 

Li W, Liu M, Su Y, Zhou X, Liu Y and Zhang X: The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells. Oncotarget. 6:44480–44494. 2015.PubMed/NCBI View Article : Google Scholar

60 

Li L and Li W: Epithelial-mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation. Pharmacol Ther. 150:33–46. 2015.PubMed/NCBI View Article : Google Scholar

61 

Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R and Shah VH: Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration. J Biol Chem. 281:39105–39113. 2006.PubMed/NCBI View Article : Google Scholar

62 

Uehara O, Takimoto K, Morikawa T, Harada F, Takai R, Adhikari BR, Itatsu R, Nakamura T, Yoshida K, Matsuoka H, et al: Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline. Oncol Lett. 14:1186–1192. 2017.PubMed/NCBI View Article : Google Scholar

63 

Rajendran R, Rajeesh MP, Shaikh S, Shanthi   and Pillai MR: Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis. Indian J Dent Res. 17:161–166. 2006.PubMed/NCBI View Article : Google Scholar

64 

Miao L, Wang Y, Xia H, Yao C, Cai H and Song Y: SPOCK1 is a novel transforming growth factor-β target gene that regulates lung cancer cell epithelial-mesenchymal transition. Biochem Biophys Res Commun. 440:792–797. 2013.PubMed/NCBI View Article : Google Scholar

65 

Hartmann U, Hülsmann H, Seul J, Röll S, Midani H, Breloy I, Hechler D, Müller R and Paulsson M: Testican-3: A brain-specific proteoglycan member of the BM-40/SPARC/osteonectin family. J Neurochem. 125:399–409. 2013.PubMed/NCBI View Article : Google Scholar

66 

Hausser HJ, Decking R and Brenner RE: Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage. Osteoarthritis Cartilage. 12:870–877. 2004.PubMed/NCBI View Article : Google Scholar

67 

Cifuentes-Diaz C, Alliel PM, Charbonnier F, De La Porte S, Molgó J, Goudou D, Rieger F and Périn JP: Regulated expression of the proteoglycan SPOCK in the neuromuscular system. Mech Dev. 94:277–282. 2000.PubMed/NCBI View Article : Google Scholar

68 

Shu YJ, Weng H, Ye YY, Hu YP, Bao RF, Cao Y, Wang XA, Zhang F, Xiang SS, Li HF, et al: SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway. Mol Cancer. 14(12)2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Singh P, Rai A, Dohare R, Arora S, Ali S, Parveen S and Syed MA: Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis. Mol Clin Oncol 12: 299-310, 2020.
APA
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., & Syed, M.A. (2020). Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis. Molecular and Clinical Oncology, 12, 299-310. https://doi.org/10.3892/mco.2020.1991
MLA
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., Syed, M. A."Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis". Molecular and Clinical Oncology 12.4 (2020): 299-310.
Chicago
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., Syed, M. A."Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis". Molecular and Clinical Oncology 12, no. 4 (2020): 299-310. https://doi.org/10.3892/mco.2020.1991
Copy and paste a formatted citation
x
Spandidos Publications style
Singh P, Rai A, Dohare R, Arora S, Ali S, Parveen S and Syed MA: Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis. Mol Clin Oncol 12: 299-310, 2020.
APA
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., & Syed, M.A. (2020). Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis. Molecular and Clinical Oncology, 12, 299-310. https://doi.org/10.3892/mco.2020.1991
MLA
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., Syed, M. A."Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis". Molecular and Clinical Oncology 12.4 (2020): 299-310.
Chicago
Singh, P., Rai, A., Dohare, R., Arora, S., Ali, S., Parveen, S., Syed, M. A."Network‑based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis". Molecular and Clinical Oncology 12, no. 4 (2020): 299-310. https://doi.org/10.3892/mco.2020.1991
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team