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Article

Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women

  • Authors:
    • Vilvanathan Vinothkumar
    • Kanagaraj Arun
    • Ganesan Arunkumar
    • Sundaramoorthy Revathidevi
    • Rajendren Ramani
    • Lakkakula V.K.S. Bhaskar
    • Avaniyapuram Kannan Murugan
    • Arasambattu Kannan Munirajan
  • View Affiliations / Copyright

    Affiliations: Department of Genetics, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu 600113, India, Institute of Social Obstetrics and Government Kasturba Gandhi Hospital for Women and Children, Chennai, Tamil Nadu 600005, India, Sickle Cell Institute Chhattisgarh (SCIC), Raipur, Chhattisgarh 492001, India, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia
  • Pages: 485-494
    |
    Published online on: February 26, 2020
       https://doi.org/10.3892/mco.2020.2003
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Abstract

A single nucleotide polymorphism (SNP) rs2853669 (A>G) in the telomerase reverse transcriptase (TERT) promoter has recently been reported in chr5:1,295,349 T>C (T349C), and was shown to be associated with increased cancer risk and poor survival in a specific population. However, at present, the role of this particular SNP with TERT promoter driver mutations and its genetic association with human papilloma virus (HPV) in patients with cervical cancer has not been determined. In the present study, the genetic association of the functional SNP rs2853669 in the presence/absence of TERT promoter hotspot mutations and HPV in patients with cervical cancer of South Indian origin was evaluated. To understand and compare the frequency of the variant allele and its risk association in different cancer types of various populations, the SNP was genotyped in 257 cervical cancer samples and 295 controls, and its associations with TERT promoter hotspot mutations and HPV were analyzed. Furthermore, an extensive search of previously published articles in PubMed, Embase and Web of Science was conducted; a meta‑analysis was carried out to elucidate the association of the SNP with different cancer types in global populations. The SNP analysis showed significantly high frequency (41%) of homozygous variant allele rs2853669 (GG) in patients with cervical cancer compared with control samples [Recessive allele model odds ratio (OR)=1.71; 95% CI=1.20‑2.43; P=0.003]. No significant interaction was observed between the TERT SNP rs2853669 and HPV status as well as other hotspot TERT promoter (C228T and C250T) mutations determined in our previous study. In addition, the overall meta‑analysis revealed a significant association of the SNP rs2853669 with other cancer types in different ethnic populations (OR=1.09; 95% CI=1.03‑1.16; P=0.004). The present results suggested that the TERT SNP rs2853669 could play an important role in the risk of cervical cancer in a South Indian population.
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1 

Low KC and Tergaonkar V: Telomerase: Central regulator of all of the hallmarks of cancer. Trends Biochem Sci. 38:426–434. 2013.PubMed/NCBI View Article : Google Scholar

2 

Maciejowski J and de Lange T: Telomeres in cancer: Tumour suppression and genome instability. Nat Rev Mol Cell Biol. 18:175–186. 2017.PubMed/NCBI View Article : Google Scholar

3 

Pestana A, Vinagre J, Sobrinho-Simões M and Soares P: TERT biology and function in cancer: Besyond immortalisation. J Mol Endocrinol. 58:R129–R146. 2017.PubMed/NCBI View Article : Google Scholar

4 

Barthel FP, Wei W, Tang M, Martinez-Ledesma E, Hu X, Amin SB, Akdemir KC, Seth S, Song X, Wang Q, et al: Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet. 49:349–357. 2017.PubMed/NCBI View Article : Google Scholar

5 

Sreedevi A, Javed R and Dinesh A: Epidemiology of cervical cancer with special focus on India. Int J Womens Health. 7:405–414. 2015.PubMed/NCBI View Article : Google Scholar

6 

Schiffman M, Wentzensen N, Wacholder S, Kinney W, Gage JC and Castle PE: Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst. 103:368–383. 2011.PubMed/NCBI View Article : Google Scholar

7 

Cancer Genome Atlas Research Network; Albert Einstein College of Medicine; Analytical Biological Services; Barretos Cancer Hospital; Baylor College of Medicine; Beckman Research Institute of City of Hope; Buck Institute for Research on Aging; Canada's Michael Smith Genome Sciences Centre; Harvard Medical School; Helen F. Graham Cancer Center & Research Institute at Christiana Care Health Services, et al: Integrated genomic and molecular characterization of cervical cancer. Nature 543: 378.384, 2017.

8 

Khurana E, Fu Y, Chakravarty D, Demichelis F, Rubin MA and Gerstein M: Role of non-coding sequence variants in cancer. Nat Rev Genet. 17:93–108. 2016.PubMed/NCBI View Article : Google Scholar

9 

Horn S, Figl A, Rachakonda PS, Fischer C, Sucker A, Gast A, Kadel S, Moll I, Nagore E, Hemminki K, et al: TERT promoter mutations in familial and sporadic melanoma. Science. 339:959–961. 2013.PubMed/NCBI View Article : Google Scholar

10 

Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan AK, Sun H, El-Naggar AK and Xing M: Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer. 20:603–610. 2013.PubMed/NCBI View Article : Google Scholar

11 

Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, Friedman AH, Friedman H, Gallia GL, Giovanella BC, et al: TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA. 110:6021–6026. 2013.PubMed/NCBI View Article : Google Scholar

12 

Vinothkumar V, Arunkumar G, Revathidevi S, Arun K, Manikandan M, Rao AK, Rajkumar KS, Ajay C, Rajaraman R, Ramani R, et al: TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas. Tumour Biol. 37:7907–7913. 2016.PubMed/NCBI View Article : Google Scholar

13 

Park CK, Lee SH, Kim JY, Kim JE, Kim TM, Lee ST, Choi SH, Park SH and Kim IH: Expression level of hTERT is regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastoma. Oncotarget. 5:3399–3407. 2014.PubMed/NCBI View Article : Google Scholar

14 

Spiegl-Kreinecker S, Lotsch D, Ghanim B, Pirker C, Mohr T, Laaber M, Weis S, Olschowski A, Webersinke G, Pichler J and Berger W: Prognostic quality of activating TERT promoter mutations in glioblastoma: Interaction with the rs2853669 polymorphism and patient age at diagnosis. Neuro Oncol. 17:1231–1240. 2015.PubMed/NCBI View Article : Google Scholar

15 

Mosrati MA, Malmström A, Lysiak M, Krysztofiak A, Hallbeck M, Milos P, Hallbeck AL, Bratthäll C, Strandéus M, Stenmark-Askmalm M and Söderkvist P: TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma. Oncotarget. 6:16663–16673. 2015.PubMed/NCBI View Article : Google Scholar

16 

Ko E, Seo HW, Jung ES, Kim BH and Jung G: The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer. Oncotarget. 7:684–699. 2016.PubMed/NCBI View Article : Google Scholar

17 

Ostör AG: Natural history of cervical intraepithelial neoplasia: A critical review. Int J Gynecol Pathol. 12:186–192. 1993.PubMed/NCBI

18 

Green MR: Molecular Cloning: A Laboratory Manual. Green MR and Sambrook J (eds). Cold Spring Harbor Laboratory Press, New York, NY, 2012.

19 

Chen B, Cole JW and Grond-Ginsbach C: Departure from Hardy Weinberg equilibrium and genotyping error. Front Genet. 8(167)2017.PubMed/NCBI View Article : Google Scholar

20 

Moher D, Liberati A, Tetzlaff J and Altman DG: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 6(e1000097)2009.PubMed/NCBI View Article : Google Scholar

21 

Wallace BC, Dahabreh IJ, Trikalinos TA, Lau J, Trow P and Schmid CH: Closing the gap between methodologists and end-users: R as a computational back-end. J Stat Software. 49(15)2012.

22 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997.PubMed/NCBI View Article : Google Scholar

23 

Zhang J, Ju H, Gao JR, Jiao XL and Lu Y: Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene-gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population. Oncotarget. 8:20235–20243. 2017.PubMed/NCBI View Article : Google Scholar

24 

Xing YL, Liu F, Li JF, Lin JC, Zhu GD, Li M, Zhang CR and Niu YY: Case-control study on impact of the telomerase reverse transcriptase gene polymorphism and additional single nucleotide polymorphism (SNP)-SNP interaction on non-small cell lung cancers risk in Chinese Han population. J Clin Lab Anal. 30:1071–1077. 2016.PubMed/NCBI View Article : Google Scholar

25 

Bayram S, Ülger Y, Sümbül AT, Kaya BY, Genç A, Rencüzoğullari E and Dadaş E: Polymorphisms in human telomerase reverse transcriptase (hTERT) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case-control study. Gene. 585:84–92. 2016.PubMed/NCBI View Article : Google Scholar

26 

Oztas E, Kara H, Kara ZP, Aydogan MU, Uras C and Ozhan G: Association between human telomerase reverse transcriptase gene variations and risk of developing breast cancer. Genet Test Mol Biomarkers. 20:459–464. 2016.PubMed/NCBI View Article : Google Scholar

27 

Jannuzzi AT, Karaman E, Oztas E, Yanar HT and Özhan G: Telomerase reverse transcriptase (TERT) gene variations and susceptibility of colorectal cancer. Genet Test Mol Biomarkers. 19:692–697. 2015.PubMed/NCBI View Article : Google Scholar

28 

Yoo SS, Do SK, Choi JE, Lee SY, Lee J, Cha SI, Kim CH and Park JY: TERT polymorphism rs2853669 influences on lung cancer risk in the Korean population. J Korean Med Sci. 30:1423–1428. 2015.PubMed/NCBI View Article : Google Scholar

29 

Shadrina AS, Boyarskikh UA, Oskina NA, Sinkina TV, Lazarev AF, Petrova VD and Filipenko ML: TERT polymorphisms rs2853669 and rs7726159 influence on prostate cancer risk in Russian population. Tumour Biol. 36:841–847. 2015.PubMed/NCBI View Article : Google Scholar

30 

Zhong R, Liu L, Zou L, Zhu Y, Chen W, Zhu B, Shen N, Rui R, Long L, Ke J, et al: Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. Mol Carcinog. 52((Suppl 1)): E118–E126. 2013.PubMed/NCBI View Article : Google Scholar

31 

Liu Z, Ma H, Wei S, Li G, Sturgis EM and Wei Q: Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev. 20:2642–2645. 2011.PubMed/NCBI View Article : Google Scholar

32 

Shen J, Gammon MD, Wu HC, Terry MB, Wang Q, Bradshaw PT, Teitelbaum SL, Neugut AI and Santella RM: Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 19:219–228. 2010.PubMed/NCBI View Article : Google Scholar

33 

Park J, Chang H, Ahn S, Lee J, Kim D, Lee K, Chon C, Moon Y and Han K: hTERT promoter gene polymorphism and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis. B. J Hepatol. 52:(Suppl 1): S345,. 2010.

34 

Varadi V, Brendle A, Grzybowska E, Johansson R, Enquist K, Butkiewicz D, Pamula-Pilat J, Pekala W, Hemminki K, Lenner P and Försti A: A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer. Cancer Genet Cytogenet. 190:71–74. 2009.PubMed/NCBI View Article : Google Scholar

35 

Savage SA, Chanock SJ, Lissowska J, Brinton LA, Richesson D, Peplonska B, Bardin-Mikolajczak A, Zatonski W, Szeszenia-Dabrowska N and Garcia-Closas M: Genetic variation in five genes important in telomere biology and risk for breast cancer. Br J Cancer. 97:832–836. 2007.PubMed/NCBI View Article : Google Scholar

36 

Jiang Y, Chen C, Chen SM, Wang YQ, Xu Y, Wang Y, Chen Z, Xiao BK and Tao ZZ: Telomerase reverse transcriptase promotes the proliferation of human laryngeal carcinoma cells through activation of the activator protein 1. Oncol Lett. 6:75–80. 2013.PubMed/NCBI View Article : Google Scholar

37 

Shay JW: Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6:584–593. 2016.PubMed/NCBI View Article : Google Scholar

38 

Liu R and Xing M: TERT promoter mutations in thyroid cancer. Endocr Relat Cancer. 23:R143–R155. 2016.PubMed/NCBI View Article : Google Scholar

39 

Shimoi T, Yoshida M, Kitamura Y, Yoshino T, Kawachi A, Shimomura A, Noguchi E, Yunokawa M, Yonemori K, Shimizu C, et al: TERT promoter hotspot mutations in breast cancer. Breast Cancer. 25:292–296. 2018.PubMed/NCBI View Article : Google Scholar

40 

Thiem S, Herold T, Krafft U, Bremmer F, Tolkach Y, Szász AM, Kriegsmann J, Gaisa NT, Niedworok C, Szarvas T and Reis H: Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer. Pathol Int. 67:597–601. 2017.PubMed/NCBI View Article : Google Scholar

41 

Liu X, Dakic A, Chen R, Disbrow GL, Zhang Y, Dai Y and Schlegel R: Cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the hTERT promoter by Myc. J Virol. 82:11568–11576. 2008.PubMed/NCBI View Article : Google Scholar

42 

Chen Y, Williams V, Filippova M, Filippov V and Duerksen-Hughes P: Viral carcinogenesis: Factors inducing DNA damage and virus integration. Cancers (Basel). 6:2155–2186. 2014.PubMed/NCBI View Article : Google Scholar

43 

Hsu CP, Hsu NY, Lee LW and Ko JL: Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter-effect on telomerase expression and telomere length maintenance in non-small cell lung cancer. Eur J Cancer. 42:1466–1474. 2006.PubMed/NCBI View Article : Google Scholar

44 

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, et al: Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 45:371–384, 384e1-2,. 2013.PubMed/NCBI View Article : Google Scholar

45 

Horikawa I, Cable PL, Afshari C and Barrett JC: Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res. 59:826–830. 1999.PubMed/NCBI

46 

Helbig S, Wockner L, Bouendeu A, Hille-Betz U, McCue K, French JD, Edwards SL, Pickett HA, Reddel RR, Chenevix-Trench G, et al: Functional dissection of breast cancer risk-associated TERT promoter variants. Oncotarget. 8:67203–67217. 2017.PubMed/NCBI View Article : Google Scholar

47 

Rachakonda PS, Hosen I, de Verdier PJ, Fallah M, Heidenreich B, Ryk C, Wiklund NP, Steineck G, Schadendorf D, Hemminki K and Kumar R: TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. Proc Natl Acad Sci USA. 110:17426–17431. 2013.PubMed/NCBI View Article : Google Scholar

48 

Nagore E, Heidenreich B, Requena C, García-Casado Z, Martorell-Calatayud A, Pont-Sanjuan V, Jimenez-Sanchez AI and Kumar R: TERT promoter mutations associate with fast-growing melanoma. Pigment Cell Melanoma Res. 29:236–238. 2016.PubMed/NCBI View Article : Google Scholar

49 

Bell RJA, Rube HT, Xavier-Magalhães A, Costa BM, Mancini A, Song JS and Costello JF: Understanding TERT promoter mutations: A common path to immortality. Mol Cancer Res. 14:315–323. 2016.PubMed/NCBI View Article : Google Scholar

50 

McMurray HR and McCance DJ: Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression. J Virol. 77:9852–9861. 2003.PubMed/NCBI View Article : Google Scholar

51 

Liu X, Dakic A, Zhang Y, Dai Y, Chen R and Schlegel R: HPV E6 protein interacts physically and functionally with the cellular telomerase complex. Proc Natl Acad Sci USA. 106:18780–18785. 2009.PubMed/NCBI View Article : Google Scholar

52 

Shen N, Lu Y, Wang X, Peng J, Zhu Y and Cheng L: Association between rs2853669 in TERT gene and the risk and prognosis of human cancer: A systematic review and meta-analysis. Oncotarget. 8:50864–50872. 2017.PubMed/NCBI View Article : Google Scholar

53 

Soerensen M, Thinggaard M, Nygaard M, Dato S, Tan Q, Hjelmborg J, Andersen-Ranberg K, Stevnsner T, Bohr VA, Kimura M, et al: Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: A cross-sectional and longitudinal analysis. Aging Cell. 11:223–227. 2012.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Vinothkumar V, Arun K, Arunkumar G, Revathidevi S, Ramani R, Bhaskar LV, Murugan AK and Munirajan AK: Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women. Mol Clin Oncol 12: 485-494, 2020.
APA
Vinothkumar, V., Arun, K., Arunkumar, G., Revathidevi, S., Ramani, R., Bhaskar, L.V. ... Munirajan, A.K. (2020). Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women. Molecular and Clinical Oncology, 12, 485-494. https://doi.org/10.3892/mco.2020.2003
MLA
Vinothkumar, V., Arun, K., Arunkumar, G., Revathidevi, S., Ramani, R., Bhaskar, L. V., Murugan, A. K., Munirajan, A. K."Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women". Molecular and Clinical Oncology 12.5 (2020): 485-494.
Chicago
Vinothkumar, V., Arun, K., Arunkumar, G., Revathidevi, S., Ramani, R., Bhaskar, L. V., Murugan, A. K., Munirajan, A. K."Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women". Molecular and Clinical Oncology 12, no. 5 (2020): 485-494. https://doi.org/10.3892/mco.2020.2003
Copy and paste a formatted citation
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Spandidos Publications style
Vinothkumar V, Arun K, Arunkumar G, Revathidevi S, Ramani R, Bhaskar LV, Murugan AK and Munirajan AK: Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women. Mol Clin Oncol 12: 485-494, 2020.
APA
Vinothkumar, V., Arun, K., Arunkumar, G., Revathidevi, S., Ramani, R., Bhaskar, L.V. ... Munirajan, A.K. (2020). Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women. Molecular and Clinical Oncology, 12, 485-494. https://doi.org/10.3892/mco.2020.2003
MLA
Vinothkumar, V., Arun, K., Arunkumar, G., Revathidevi, S., Ramani, R., Bhaskar, L. V., Murugan, A. K., Munirajan, A. K."Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women". Molecular and Clinical Oncology 12.5 (2020): 485-494.
Chicago
Vinothkumar, V., Arun, K., Arunkumar, G., Revathidevi, S., Ramani, R., Bhaskar, L. V., Murugan, A. K., Munirajan, A. K."Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women". Molecular and Clinical Oncology 12, no. 5 (2020): 485-494. https://doi.org/10.3892/mco.2020.2003
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