Pulmonary metastasectomy is associated with prolonged survival among patients with bone and soft tissue sarcoma

Shimizu,Junya; Emori,Makoto; Murahashi,Yasutaka; Sonoda,Tomoko; Mishina,Taijiro; Miyajima,Masahiro; Watanabe,Atsushi; Sugita,Shintaro; Takada,Kohichi; Murase,Kazuyuki; Hasegawa,Tadashi; Yamashita,Toshihiko

doi:10.3892/mco.2020.2009

Pulmonary metastasectomy is associated with prolonged survival among patients with bone and soft tissue sarcoma

Authors:
- Junya Shimizu
- Makoto Emori
- Yasutaka Murahashi
- Tomoko Sonoda
- Taijiro Mishina
- Masahiro Miyajima
- Atsushi Watanabe
- Shintaro Sugita
- Kohichi Takada
- Kazuyuki Murase
- Tadashi Hasegawa
- Toshihiko Yamashita
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Affiliations: Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060‑8543, Japan, Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060‑8543, Japan, Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060‑8543, Japan, Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060‑8543, Japan, Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060‑8543, Japan
Published online on: February 27, 2020 https://doi.org/10.3892/mco.2020.2009
Pages: 429-434
Copyright: © Shimizu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the survival impact of surgical resection among patients with pulmonary metastases from bone and soft tissue sarcomas. A total of 34 consecutive patients with ≤5 pulmonary metastases from bone and soft tissue sarcomas were retrospectively reviewed. The patients included 19 men and 15 women, with a median age of 64.0 years and a median follow‑up of 14.5 months. The oncological outcome was compared between patients who underwent surgical and non‑surgical treatment. A total of 22 patients underwent surgery and 12 patients did not undergo surgery. The surgery group had 3‑ and 5 year overall survival rates of 62 and 53%, respectively. None of the patients in the non‑surgery group survived to 3 years. Compared with the non‑surgery group, surgery achieved significantly better 3‑ and 5 year overall survival rates. Pulmonary metastasectomy was associated with significantly improved survival among patients who were aged <64 years (P=0.0155), as well as those who were aged ≥64 years (P=0.0444), which indicated that age was not associated with a difference in survival between the two groups. Therefore, pulmonary metastasectomy may improve the prognosis of patients with pulmonary metastases from bone and soft tissue sarcomas.

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1	Billingsley KG, Burt ME, Jara E, Ginsberg RJ, Woodruff JM, Leung DH and Brennan MF: Pulmonary metastases from soft tissue sarcoma: Analysis of patterns of diseases and postmetastasis survival. Ann Surg. 229:602–610. 1999.PubMed/NCBI View Article : Google Scholar
2	Hamaji M, Chen F, Miyamoto E, Kondo T, Ohata K, Motoyama H, Hijiya K, Menju T, Aoyama A, Sato T, et al: Surgical and non-surgical management of repeat pulmonary metastasis from sarcoma following first pulmonary metastasectomy. Surg Today. 46:1296–1300. 2016.PubMed/NCBI View Article : Google Scholar
3	Treasure T, Fiorentino F, Scarci M, Møller H and Utley M: Pulmonary metastasectomy for sarcoma: A systematic review of reported outcomes in the context of thames cancer registry data. BMJ Open. 8(e001736)2012.PubMed/NCBI View Article : Google Scholar
4	Shimizu J, Emori M, Yasutaka M and Yamashita T: Pulmonary metastasectomy is associated with a survival benefit among patients with bone and soft tissue sarcoma. J East Jpn Orthop Traumatol. 31:16–21. 2019.(In Japanese).
5	Sobin LH, Gospodarowicz MK and Wittekind C (eds): TNM classification of malignant tumors 7^th ed: International Union against Cancer (UICC). Vol 78. Elsevier BV, Netherlands, pp1278, 2010.
6	Coindre JM: Grading of soft tissue sarcomas: Review and update. Arch Pathol Lab Med. 130:1448–1453. 2006.PubMed/NCBI View Article : Google Scholar
7	Schur S, Hoetzenecker K, Lamm W, Koestler WJ, Lang G, Amann G, Funovics P, Nemecek E, Noebauer I, Windhager R, et al: Pulmonary metastasectomy for soft tissue sarcoma-report from a dual institution experience at the medical university of vienna. Eur J Cancer. 50:2289–2297. 2014.PubMed/NCBI View Article : Google Scholar
8	Rehders A, Hosch SB, Scheunemann P, Stoecklein NH, Knoefel WT and Peiper M: Benefit of surgical treatment of lung metastasis in soft tissue sarcoma. Arch Surg. 142:70–75. 2007.PubMed/NCBI View Article : Google Scholar
9	Rusch VW: Pulmonary metastasectomy. Current indications. Chest. 107 (6 Suppl):322S–331S. 1995.PubMed/NCBI View Article : Google Scholar
10	Lin AY, Kotova S, Yanagawa J, Elbuluk O, Wang G, Kar N, Elashoff D, Grogan T, Cameron RB, Singh A, et al: Risk stratification of patients undergoing pulmonary metastasectomy for soft tissue and bone sarcomas. J Thorac Cardiovasc Surg. 149:85–92. 2015.PubMed/NCBI View Article : Google Scholar
11	Casson AG, Putnam JB, Natarajan G, Johnston DA, Mountain C, McMurtrey M and Roth JA: Five-year survival after pulmonary metastasectomy for adult soft tissue sarcoma. Cancer. 69:662–668. 1992.PubMed/NCBI View Article : Google Scholar
12	Meyer WH, Schell MJ, Kumar AP, Rao BN, Green AA, Champion J and Pratt CB: Thoracotomy for pulmonary metastatic osteosarcoma. An analysis of prognostic indicators of survival. Cancer. 59:374–379. 1987.PubMed/NCBI View Article : Google Scholar
13	Thomford NR, Woolner LB and Clagett OT: The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg. 49:357–363. 1965.PubMed/NCBI
14	Smith R, Pak Y, Kraybill W and Kane JM III: Factors associated with actual long-term survival following soft tissue sarcoma pulmonary metastasectomy. Eur J Surg Oncol. 35:356–361. 2009.PubMed/NCBI View Article : Google Scholar
15	Garcia Franco CE, Torre W, Tamura A, Guillen-Grima F, San-Julian M, Martin-Algarra S and Pardo FJ: Long-Term results after resection for bone sarcoma pulmonary metastases. Eur J Cardiothorac Surg. 37:1205–1208. 2010.PubMed/NCBI View Article : Google Scholar
16	Kim S, Ott HC, Wright CD, Wain JC, Morse C, Gaissert HA, Donahue DM, Mathisen DJ and Lanuti M: Pulmonary resection of metastatic sarcoma: Prognostic factors associated with improved outcomes. Ann Thorac Surg. 92:1780–1786. 2011.PubMed/NCBI View Article : Google Scholar
17	Mizuno T, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S and Yokoi K: Pulmonary metastasectomy for osteogenic and soft tissue sarcoma: Who really benefits from surgical treatment? Eur J Cardiothorac Surg. 43:795–799. 2013.PubMed/NCBI View Article : Google Scholar