Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report

Noda,Hirotaka; Masuda,Kazuyoshi; Kanbara,Masami; Maeda,Hiromi; Kobayashi,Tadao   K.; Yutani,Chikao

doi:10.3892/mco.2020.2030

June-2020 Volume 12 Issue 6

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June-2020 Volume 12 Issue 6

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Case Report

Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report

Authors:
- Hirotaka Noda
- Kazuyoshi Masuda
- Masami Kanbara
- Hiromi Maeda
- Tadao K. Kobayashi
- Chikao Yutani
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Affiliations: Department of Pathology, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661‑0976, Japan, Department of Clinical Laboratory, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661‑0976, Japan, Division of Health Sciences, Cancer Education and Research Center, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan
Pages: 592-596
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Published online on: April 10, 2020

https://doi.org/10.3892/mco.2020.2030
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Abstract

Sporadic gastrin‑producing neuroendocrine tumors (NETs) of the duodenum present with either Zollinger‑Ellison syndrome or unspecific syndromes. Ki‑67 scoring in cytopathology is an alternative approach for establishing the gastrinoma grade. Although the majority of NETs, including gastrinomas, occur in the duodenum, most research regarding the Ki‑67 index is focused on tumors of pancreatic origin. To the best of our knowledge, there is no study on the Ki‑67 index for cytological analysis of duodenal gastrinoma. The current report presents two cases of a 56‑year‑old man and a 66‑year‑old woman with NET G1 and G2 gastrinoma, respectively, arising in the duodenal bulb. The present report focused on the differences in nuclear pleomorphism and Ki‑67 index between these two cases.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report

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