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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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July-2020 Volume 13 Issue 1

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Case Report Open Access

Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report

  • Authors:
    • Michiko Takimoto Sato
    • Yasuyuki Ikezawa
    • Mineyoshi Sato
    • Akira Suzuki
    • Yasutaka Kawai
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Oji General Hospital, Tomakomai, Hokkaido 0538506, Japan, Department of Pathology, Oji General Hospital, Tomakomai, Hokkaido 0538506, Japan
    Copyright: © Sato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 43-47
    |
    Published online on: May 13, 2020
       https://doi.org/10.3892/mco.2020.2045
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Abstract

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, accounting for 3% of all lung cancers. The prognosis is poor and the standard therapy has not been well established. Herein, we report a case of advanced LCNEC of the lung that responded to nivolumab. The patient was a 62‑year old man with stage IVB LCNEC of the lung. The disease progressed following the administration of second‑line chemotherapy, and he was treated with nivolumab 3 mg/kg as the third‑line treatment. Although treatment was ceased after two cycles due to interstitial pneumonia, the disease remained stable for approximately six months under observation. There was no other adverse event related to nivolumab. Following patient mortality from tumor progression, PD‑L1 expression was observed to be negative (tumor proportion score <1%) by a re‑examination of the primary biopsy specimen. The case herein suggests that nivolumab may be a possible treatment option for LCNEC.
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Copy and paste a formatted citation
Spandidos Publications style
Sato MT, Ikezawa Y, Sato M, Suzuki A and Kawai Y: Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report. Mol Clin Oncol 13: 43-47, 2020.
APA
Sato, M.T., Ikezawa, Y., Sato, M., Suzuki, A., & Kawai, Y. (2020). Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report. Molecular and Clinical Oncology, 13, 43-47. https://doi.org/10.3892/mco.2020.2045
MLA
Sato, M. T., Ikezawa, Y., Sato, M., Suzuki, A., Kawai, Y."Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report". Molecular and Clinical Oncology 13.1 (2020): 43-47.
Chicago
Sato, M. T., Ikezawa, Y., Sato, M., Suzuki, A., Kawai, Y."Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report". Molecular and Clinical Oncology 13, no. 1 (2020): 43-47. https://doi.org/10.3892/mco.2020.2045
Copy and paste a formatted citation
x
Spandidos Publications style
Sato MT, Ikezawa Y, Sato M, Suzuki A and Kawai Y: Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report. Mol Clin Oncol 13: 43-47, 2020.
APA
Sato, M.T., Ikezawa, Y., Sato, M., Suzuki, A., & Kawai, Y. (2020). Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report. Molecular and Clinical Oncology, 13, 43-47. https://doi.org/10.3892/mco.2020.2045
MLA
Sato, M. T., Ikezawa, Y., Sato, M., Suzuki, A., Kawai, Y."Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report". Molecular and Clinical Oncology 13.1 (2020): 43-47.
Chicago
Sato, M. T., Ikezawa, Y., Sato, M., Suzuki, A., Kawai, Y."Large cell neuroendocrine carcinoma of the lung that responded to nivolumab: A case report". Molecular and Clinical Oncology 13, no. 1 (2020): 43-47. https://doi.org/10.3892/mco.2020.2045
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