Open Access

Immunohistochemical analysis of SOX2 expression in small‑cell neuroendocrine carcinoma of the endometrium

  • Authors:
    • Yusuke Ebisu
    • Mitsuaki Ishida
    • Tomomi Mizokami
    • Masato Kita
    • Hidetaka Okada
    • Koji Tsuta
  • View Affiliations

  • Published online on: May 22, 2020     https://doi.org/10.3892/mco.2020.2051
  • Pages: 115-118
  • Copyright: © Ebisu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Small‑cell neuroendocrine carcinoma (NEC) of the endometrium is an extremely rare and highly aggressive carcinoma. Sex‑determining region Y‑box 2 (SOX2) is a master transcription factor regulating the self‑renewal, maintenance of stem cell properties and pluripotency of embryonic stem cells, and recent studies revealed that SOX2 plays important roles in cancer growth and progression in several types of carcinomas, including small‑cell neuroendocrine carcinoma (NEC) of the lung and oesophagus. Few studies to date have analysed the association between SOX2 and endometrioid carcinoma, whereas the expression of SOX2 in small‑cell NEC of the endometrium has not been investigated. The aim of the present study was to analyse the expression status of SOX2, p16 and paired‑box gene (PAX) 8, a useful Müllerian marker, in endometrial small‑cell NEC. A total of 4 patients with small‑cell NEC of the endometrium were enrolled (median age, 70 years). Immunohistochemical studies revealed SOX2 expression in 3 patients and p16 expression in all patients. No patients exhibited positive immunoreactivity for PAX8. SOX2 expression has been reported to be associated with the pathogenesis of small‑cell NEC of the oesophagus. Therefore, the results of the present study indicated that SOX2 expression plays an important role in the development of small‑cell NEC of the endometrium and the oesophagus. Moreover, expression of p16 and loss of PAX8 do not indicate the origin of small‑cell NEC of the endometrium.

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August-2020
Volume 13 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Ebisu, Y., Ishida, M., Mizokami, T., Kita, M., Okada, H., & Tsuta, K. (2020). Immunohistochemical analysis of SOX2 expression in small‑cell neuroendocrine carcinoma of the endometrium. Molecular and Clinical Oncology, 13, 115-118. https://doi.org/10.3892/mco.2020.2051
MLA
Ebisu, Y., Ishida, M., Mizokami, T., Kita, M., Okada, H., Tsuta, K."Immunohistochemical analysis of SOX2 expression in small‑cell neuroendocrine carcinoma of the endometrium". Molecular and Clinical Oncology 13.2 (2020): 115-118.
Chicago
Ebisu, Y., Ishida, M., Mizokami, T., Kita, M., Okada, H., Tsuta, K."Immunohistochemical analysis of SOX2 expression in small‑cell neuroendocrine carcinoma of the endometrium". Molecular and Clinical Oncology 13, no. 2 (2020): 115-118. https://doi.org/10.3892/mco.2020.2051