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Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma

  • Authors:
    • Bantita Phruttinarakorn
    • Thanyanan Reungwetwattana
    • Pimpin Incharoen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Copyright: © Phruttinarakorn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 12
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    Published online on: July 1, 2020
       https://doi.org/10.3892/mco.2020.2082
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Abstract

Genetic alteration and programmed death‑ligand 1 (PD‑L1) expression have been revealed to be associated with various subtypes of pulmonary adenocarcinoma (ADC). The present study aimed to explore the association between histological subtypes and genetic alterations and PD‑L1 expression. A total of 375 cases of pulmonary ADC were included. Genetic alterations were determined using next generation sequencing (NGS) in 136 cases. PD‑L1 expression was detected by immunohistochemistry (based on clone 22C3) in the remaining 239 cases. Mutations in the epidermal growth factor receptor gene (EGFR) were detected in 76 (55.8%) cases associated with the papillary subtype (P=0.038). Mutations in the Kirsten rat sarcoma viral oncogene homolog gene (KRAS) were present in 46 (33.8%) cases associated with the lepidic subtype (P<0.001) and mucinous ADC (P=0.037). PD‑L1 expression was identified in 63 (26.4%) cases associated with the solid subtype (P<0.001). In conclusion, the present study demonstrated that EGFR and KRAS mutations, alongside PD‑L1 protein expression are significantly associated with specific subtypes of pulmonary ADC. These results should aid our ability to accurately select appropriate areas of the heterogeneous tumor for molecular testing methods and to predict patient outcomes and prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Phruttinarakorn B, Reungwetwattana T and Incharoen P: Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma. Mol Clin Oncol 13: 12, 2020.
APA
Phruttinarakorn, B., Reungwetwattana, T., & Incharoen, P. (2020). Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma. Molecular and Clinical Oncology, 13, 12. https://doi.org/10.3892/mco.2020.2082
MLA
Phruttinarakorn, B., Reungwetwattana, T., Incharoen, P."Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma". Molecular and Clinical Oncology 13.3 (2020): 12.
Chicago
Phruttinarakorn, B., Reungwetwattana, T., Incharoen, P."Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma". Molecular and Clinical Oncology 13, no. 3 (2020): 12. https://doi.org/10.3892/mco.2020.2082
Copy and paste a formatted citation
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Spandidos Publications style
Phruttinarakorn B, Reungwetwattana T and Incharoen P: Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma. Mol Clin Oncol 13: 12, 2020.
APA
Phruttinarakorn, B., Reungwetwattana, T., & Incharoen, P. (2020). Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma. Molecular and Clinical Oncology, 13, 12. https://doi.org/10.3892/mco.2020.2082
MLA
Phruttinarakorn, B., Reungwetwattana, T., Incharoen, P."Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma". Molecular and Clinical Oncology 13.3 (2020): 12.
Chicago
Phruttinarakorn, B., Reungwetwattana, T., Incharoen, P."Association of histologic subtypes with genetic alteration and PD‑L1 expression in pulmonary adenocarcinoma". Molecular and Clinical Oncology 13, no. 3 (2020): 12. https://doi.org/10.3892/mco.2020.2082
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