Combination of Juzentaihoto and chemotherapy improves the prognosis of patients with postoperative recurrence of non‑small cell lung cancer

  • Authors:
    • Hideki Kawai
    • Yoshitaro Saito
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  • Published online on: July 3, 2020     https://doi.org/10.3892/mco.2020.2083
  • Article Number: 13
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Abstract

Kampo medicines have been used to reduce chemotherapy‑induced adverse events. However, whether Kampo medicine can improve the prognosis of cancer remains unclear. The present study aimed to clarify the effect of Juzentaihoto (TJ‑48) on patients with postoperative recurrence of non‑small cell lung cancer. In total, 45 patients with postoperative recurrent non‑small cell lung cancer scheduled for first‑line chemotherapy were enrolled in the present study. Differences in progression‑free survival between the chemotherapy combined with TJ‑48 and chemotherapy only groups were analyzed. Body weight change and prognostic nutritional index were also evaluated to examine whether these factors were influenced by TJ‑48 administration. Multivariate analysis was performed to detect independent prognostic factors. A significant increase was observed in progression‑free survival in the chemotherapy plus TJ‑48 group compared with in the chemotherapy alone group (P<0.001). Significant decreases in body weight and prognostic nutritional index score were observed in the chemotherapy alone group (P<0.01 and P<0.05, respectively); however, these decreases were not observed in the chemotherapy plus TJ‑48 group. Multivariate analysis revealed that TJ‑48 administration with chemotherapy was an independent prognostic factor. In conclusion, TJ‑48 combined with chemotherapy may improve the progression‑free survival of patients with postoperative recurrence of non‑small cell lung cancer by preventing nutritional disorders.
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September-2020
Volume 13 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Kawai H and Kawai H: Combination of Juzentaihoto and chemotherapy improves the prognosis of patients with postoperative recurrence of non‑small cell lung cancer. Mol Clin Oncol 13: 13, 2020
APA
Kawai, H., & Kawai, H. (2020). Combination of Juzentaihoto and chemotherapy improves the prognosis of patients with postoperative recurrence of non‑small cell lung cancer. Molecular and Clinical Oncology, 13, 13. https://doi.org/10.3892/mco.2020.2083
MLA
Kawai, H., Saito, Y."Combination of Juzentaihoto and chemotherapy improves the prognosis of patients with postoperative recurrence of non‑small cell lung cancer". Molecular and Clinical Oncology 13.3 (2020): 13.
Chicago
Kawai, H., Saito, Y."Combination of Juzentaihoto and chemotherapy improves the prognosis of patients with postoperative recurrence of non‑small cell lung cancer". Molecular and Clinical Oncology 13, no. 3 (2020): 13. https://doi.org/10.3892/mco.2020.2083