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Review Open Access

Historical retrospective of the SRC oncogene and new perspectives (Review)

  • Authors:
    • Aristofania Simatou
    • George Simatos
    • Maria Goulielmaki
    • Demetrios   A. Spandidos
    • Stella Baliou
    • Vassilios Zoumpourlis
  • View Affiliations / Copyright

    Affiliations: First Breast Unit, Saint Savas Cancer Hospital, 11522 Athens, Greece, Biomedical Applications Unit, Institute of Chemical Biology, National Hellenic Research Foundation (NHRF), 11635 Athens, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Simatou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 21
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    Published online on: July 14, 2020
       https://doi.org/10.3892/mco.2020.2091
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Abstract

Since its first discovery as part of the Rous sarcoma virus (RSV) genome, the c‑SRC (SRC) proto‑oncogene has been proved a key regulator of cancer development and progression, and thus it has been highlighted as an attractive target for anti‑cancer therapeutic strategies. Though the exact mechanisms of its action are still not fully understood, SRC protein mediates crucial normal cell functions, such as cell development, proliferation and survival, and its dysregulation is considered as an oncogenic signature and a driving force for cancer initiation. In the present review, we present a flashback to the history of the Src research, while focusing on the most important milestones in the field. Moreover, we investigate the proposed regulatory mechanisms and molecules that mediate its action in order to designate putative therapeutic targets and useful prognostic and/or diagnostic tools. Furthermore, we present and discuss existing therapeutic approaches that are explored in clinical settings.
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Copy and paste a formatted citation
Spandidos Publications style
Simatou A, Simatos G, Goulielmaki M, Spandidos DA, Baliou S and Zoumpourlis V: Historical retrospective of the SRC oncogene and new perspectives (Review). Mol Clin Oncol 13: 21, 2020.
APA
Simatou, A., Simatos, G., Goulielmaki, M., Spandidos, D.A., Baliou, S., & Zoumpourlis, V. (2020). Historical retrospective of the SRC oncogene and new perspectives (Review). Molecular and Clinical Oncology, 13, 21. https://doi.org/10.3892/mco.2020.2091
MLA
Simatou, A., Simatos, G., Goulielmaki, M., Spandidos, D. A., Baliou, S., Zoumpourlis, V."Historical retrospective of the SRC oncogene and new perspectives (Review)". Molecular and Clinical Oncology 13.4 (2020): 21.
Chicago
Simatou, A., Simatos, G., Goulielmaki, M., Spandidos, D. A., Baliou, S., Zoumpourlis, V."Historical retrospective of the SRC oncogene and new perspectives (Review)". Molecular and Clinical Oncology 13, no. 4 (2020): 21. https://doi.org/10.3892/mco.2020.2091
Copy and paste a formatted citation
x
Spandidos Publications style
Simatou A, Simatos G, Goulielmaki M, Spandidos DA, Baliou S and Zoumpourlis V: Historical retrospective of the SRC oncogene and new perspectives (Review). Mol Clin Oncol 13: 21, 2020.
APA
Simatou, A., Simatos, G., Goulielmaki, M., Spandidos, D.A., Baliou, S., & Zoumpourlis, V. (2020). Historical retrospective of the SRC oncogene and new perspectives (Review). Molecular and Clinical Oncology, 13, 21. https://doi.org/10.3892/mco.2020.2091
MLA
Simatou, A., Simatos, G., Goulielmaki, M., Spandidos, D. A., Baliou, S., Zoumpourlis, V."Historical retrospective of the SRC oncogene and new perspectives (Review)". Molecular and Clinical Oncology 13.4 (2020): 21.
Chicago
Simatou, A., Simatos, G., Goulielmaki, M., Spandidos, D. A., Baliou, S., Zoumpourlis, V."Historical retrospective of the SRC oncogene and new perspectives (Review)". Molecular and Clinical Oncology 13, no. 4 (2020): 21. https://doi.org/10.3892/mco.2020.2091
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