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Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review

  • Authors:
    • Jorge Lourenço
    • Cristina Ferreira
    • Daniela Marado
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Coimbra University Central Hospital, 3000-075 Coimbra, Portugal, Department of Pneumology, Coimbra University Central Hospital, 3000-075 Coimbra, Portugal
    Copyright: © Lourenço et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
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    Published online on: July 22, 2020
       https://doi.org/10.3892/mco.2020.2100
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Abstract

Langerhans cell histiocytosis (LCH) is a rare systemic and heterogeneous disease secondary to proliferation and diffuse infiltration of immature CD1a‑positive dendritic cells, also known as Langerhans cells. LCH affects predominantly paediatric patients and is rarely diagnosed in adulthood. Despite its worldwide prevalence, most reported cases are found in the Japanese population. There is no consensus regarding treatment strategy due to the low incidence of this disease and the diversity of symptoms that appear. An integrative literature review was conducted based on the PubMed database using MeSH terms ‘Langerhans’, ‘histiocytosis’ and ‘adult’. The present report describes a case of a successfully treated LCH‑induced central diabetes insipidus (uncommon presentation in adult patients) as well as an updated review of current evidence published on this matter.
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Copy and paste a formatted citation
Spandidos Publications style
Lourenço J, Ferreira C and Marado D: Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review. Mol Clin Oncol 13: 30, 2020.
APA
Lourenço, J., Ferreira, C., & Marado, D. (2020). Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review. Molecular and Clinical Oncology, 13, 30. https://doi.org/10.3892/mco.2020.2100
MLA
Lourenço, J., Ferreira, C., Marado, D."Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review". Molecular and Clinical Oncology 13.4 (2020): 30.
Chicago
Lourenço, J., Ferreira, C., Marado, D."Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review". Molecular and Clinical Oncology 13, no. 4 (2020): 30. https://doi.org/10.3892/mco.2020.2100
Copy and paste a formatted citation
x
Spandidos Publications style
Lourenço J, Ferreira C and Marado D: Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review. Mol Clin Oncol 13: 30, 2020.
APA
Lourenço, J., Ferreira, C., & Marado, D. (2020). Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review. Molecular and Clinical Oncology, 13, 30. https://doi.org/10.3892/mco.2020.2100
MLA
Lourenço, J., Ferreira, C., Marado, D."Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review". Molecular and Clinical Oncology 13.4 (2020): 30.
Chicago
Lourenço, J., Ferreira, C., Marado, D."Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review". Molecular and Clinical Oncology 13, no. 4 (2020): 30. https://doi.org/10.3892/mco.2020.2100
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