Survival and prognostic factors in patients undergoing extended pulmonary metastasectomy

Kawaguchi,Yo; Hanaoka,Jun; Ohshio,Yasuhiko; Okamoto,Keigo; Kaku,Ryosuke; Hayashi,Kazuki; Shiratori,Takuya; Yoden,Makoto

doi:10.3892/mco.2020.2118

November-2020 Volume 13 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-2020 Volume 13 Issue 5

Full Size Image

Article

Survival and prognostic factors in patients undergoing extended pulmonary metastasectomy

Authors:
- Yo Kawaguchi
- Jun Hanaoka
- Yasuhiko Ohshio
- Keigo Okamoto
- Ryosuke Kaku
- Kazuki Hayashi
- Takuya Shiratori
- Makoto Yoden
View Affiliations / Copyright

Affiliations: Division of General Thoracic Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
Article Number: 48
|
Published online on: August 20, 2020

https://doi.org/10.3892/mco.2020.2118
Expand metrics +

Abstract

Extended pulmonary metastasectomy has become feasible in patients with extrapulmonary metastases and multiple or bilateral pulmonary metastases. Even peritoneal dissemination is considered to be curable in modern medicine. Therefore, it is necessary to analyze the prognosis of patients undergoing complete pulmonary metastasectomy. A total of 80 patients who underwent pulmonary resection for lung metastases were retrospectively analyzed. The eligibility criteria for the present study were as follows: i) the primary tumor was controlled; ii) if extrapulmonary metastases (including peritoneal dissemination) existed, these were controlled by local treatment or such treatment was planned; iii) the one to three months follow‑up computed tomography (CT) following the first assessment revealed no increase of pulmonary metastatic disease; iv) pulmonary metastases could be resected completely. The overall 5‑ and 10‑year survival rates were 71.7 and 41.5%, respectively. Applying the extended criteria for surgery, the present study demonstrated that pulmonary metastasectomy resulted in a good patient prognosis.

View Figures

View References

1	Thomford NR, Woolner LB and Clagett OT: The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg. 49:357–363. 1965.PubMed/NCBI
2	Canbay E, Torun BC, Torun ES and Yonemura Y: Evolution of management in peritoneal surface malignancies. Ulus Cerrahi Derg. 32:203–207. 2016.PubMed/NCBI View Article : Google Scholar
3	Younes RN, Abrao F and Gross J: Pulmonary metastasectomy for colorectal cancer: Long-Term survival and prognostic factors. Int J Surg. 11:244–248. 2013.PubMed/NCBI View Article : Google Scholar
4	Younes RN, Fares AL and Gross JL: Pulmonary metastasectomy: A multivariate analysis of 440 patients undergoing complete resection. Interact Cardiovasc Thorac Surg. 14:156–161. 2012.PubMed/NCBI View Article : Google Scholar
5	Chen F, Hanaoka N, Sato K, Fujinaga T, Sonobe M, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, et al: Prognostic factors of pulmonary metastasectomy for colorectal carcinomas. World J Surg. 33:505–511. 2009.PubMed/NCBI View Article : Google Scholar
6	McAfee MK, Allen MS, Trastek VF, Ilstrup DM, Deschamps C and Pairolero PC: Colorectal lung metastases: Results of surgical excision. Ann Thorac Surg. 53:780–785. 1992.PubMed/NCBI View Article : Google Scholar
7	Saito Y, Omiya H, Kohno K, Kobayashi T, Itoi K, Teramachi M, Sasaki M, Suzuki H, Takao H and Nakade M: Pulmonary metastasectomy for 165 patients with colorectal carcinoma: A prognostic assessment. J Thorac Cardiovasc Surg. 124:1007–1013. 2002.PubMed/NCBI View Article : Google Scholar
8	Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T and Moran B: Pathology and prognosis in pseudomyxoma peritonei: A review of 274 cases. J Clin Pathol. 65:919–923. 2012.PubMed/NCBI View Article : Google Scholar
9	Kawaguchi Y, Hanaoka J, Ohshio Y, Okamoto K, Kaku R, Hayashi K, Shiratori T and Yoden M: Patient survival after surgical management in intrathoracic pseudomyxoma peritonei. Ann Surg Oncol. 26:238–243. 2019.PubMed/NCBI View Article : Google Scholar
10	Pastorino U, Buyse M, Friedel G, Ginsberg RJ, Girard P, Goldstraw P, Johnston M, McCormack P, Pass H and Putnam JB Jr: International Registry of Lung Metastases. Long-Term results of lung metastasectomy: Prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg. 113:37–49. 1997.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Survival and prognostic factors in patients undergoing extended pulmonary metastasectomy

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles