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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2020 Volume 13 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Case Report Open Access

Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature

  • Authors:
    • Lei Song
    • Dejian Pan
    • Rengui Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, The 904 Hospital of The PLA (Chinese People's Liberation Army), Wuxi, Jiangsu 214044, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 54
    |
    Published online on: August 24, 2020
       https://doi.org/10.3892/mco.2020.2124
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Abstract

The main therapeutic strategy for metastatic Myxofibrosarcoma (MFS) is palliative chemotherapy. A number of studies have demonstrated that anti‑angiogenic therapy and immunotherapy could improve the survival rate of patients with metastases. However, the effectiveness of the combination of anti‑angiogenic therapy and immunotherapy for the therapy of MFS is undetermined. The current study reports a case of metastatic myxofibrosarcoma that was treated with combination Nivolumab (monoclonal antibody, PD‑1 inhibitor) and Bevacizumab (monoclonal antibody, anti‑VEGF) after progression from the single use of Nivolumab. The aim of the current study is to assess the efficacy and safety of Nivolumab and Bevacizumab for metastatic myxofibrosarcoma and to review the literature. Up to the termination of the follow‑up, the patient achieved a partial response for 16 months, had an overall survival for over 29 months since the metastasis and demonstrated a sustained benefit from treatment. The most frequent adverse events were fatigue, abnormality of Alanine aminotransferase (ALT), hypertension and proteinuria. Nivolumab and Bevacizumab treatment indicate beneficial clinical effects and are indicated to be safe to use in patients with metastatic myxofibrosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Song L, Pan D and Zhou R: Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature. Mol Clin Oncol 13: 54, 2020.
APA
Song, L., Pan, D., & Zhou, R. (2020). Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature. Molecular and Clinical Oncology, 13, 54. https://doi.org/10.3892/mco.2020.2124
MLA
Song, L., Pan, D., Zhou, R."Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature". Molecular and Clinical Oncology 13.5 (2020): 54.
Chicago
Song, L., Pan, D., Zhou, R."Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature". Molecular and Clinical Oncology 13, no. 5 (2020): 54. https://doi.org/10.3892/mco.2020.2124
Copy and paste a formatted citation
x
Spandidos Publications style
Song L, Pan D and Zhou R: Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature. Mol Clin Oncol 13: 54, 2020.
APA
Song, L., Pan, D., & Zhou, R. (2020). Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature. Molecular and Clinical Oncology, 13, 54. https://doi.org/10.3892/mco.2020.2124
MLA
Song, L., Pan, D., Zhou, R."Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature". Molecular and Clinical Oncology 13.5 (2020): 54.
Chicago
Song, L., Pan, D., Zhou, R."Combination nivolumab and bevacizumab for metastatic myxofibrosarcoma: A case report and review of the literature". Molecular and Clinical Oncology 13, no. 5 (2020): 54. https://doi.org/10.3892/mco.2020.2124
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