Primary acral amelanotic melanoma: A rare case report

Zhang,Jiaojiao; Yang,Huizhi; Lin,Jiaxi; Zhang,Fang; Shi,Jianqiang; Chen,Rongyi

doi:10.3892/mco.2020.2129

November-2020 Volume 13 Issue 5

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November-2020 Volume 13 Issue 5

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Case Report Open Access

Primary acral amelanotic melanoma: A rare case report

Authors:
- Jiaojiao Zhang
- Huizhi Yang
- Jiaxi Lin
- Fang Zhang
- Jianqiang Shi
- Rongyi Chen
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Affiliations: Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510095, P.R. China, Department of Dermatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 59
|
Published online on: September 3, 2020

https://doi.org/10.3892/mco.2020.2129
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Abstract

The aim of the present study was to present a rare case of primary acral amelanotic malignant melanoma (AMM). A 61‑year‑old man developed an aggressive tumor in the front part of the sole of his left foot, which continued to increase in size for >1 year. The biopsy results revealed epidermis loss, ulcer formation, and the presence of abundant allotropic tumor cells throughout the dermis, with deeply stained nuclei, light reddish cytoplasm and visible multinucleated giant cells with heterogeneous nuclear division. The tumor cells exhibited partial formation of nests and bundled distribution, and there were no observed pigment particles. The diagnosis was confirmed as AMM based on the findings of the histopathological examination and immunohistochemical staining for Ki67 (+++), Melan‑A (+++), human melanoma black 45 (+), CD20 (‑), cytokeratin (CK)7 (‑) and CK5/6 (‑).

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary acral amelanotic melanoma: A rare case report

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