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Article

Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases

  • Authors:
    • Tatiane Burle De Siqueira Ferroni Plentz
    • Elaine Cristina Candido
    • Lais Flausino Dias
    • Maria Carolina Szymanski Toledo
    • Diama Bhadra Vale
    • Julio Cesar Teixeira
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), Campinas, 13083‑881 São Paulo, Brazil
  • Article Number: 81
    |
    Published online on: October 6, 2020
       https://doi.org/10.3892/mco.2020.2151
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Abstract

The present study aimed to assess the diagnosis, treatment and follow‑up of uterine sarcoma cases. A retrospective cohort study with 122 women recruited between 2001 and 2016 was performed. The data regarding epidemiology, clinical presentation, treatment and follow‑up were analyzed based on the following histological types: Carcinosarcoma, leiomyosarcoma, endometrial stromal sarcoma (ESS) and adenosarcoma. Statistical analysis included descriptive statistics, logistic regression and survival curves. The diagnosis of uterine sarcoma exhibited an increasing trend of +1.2 new cases every 2 years (P=0.044) and comprised 10% of all uterine cancer diagnoses. There were 47% carcinosarcomas, 22% leiomyosarcomas, 16% ESS and 14% adenosarcomas. The majority of the women was ≥60 years old (62%). Among the subjects, 77% were postmenopausal, 61% had a body mass index up to 29.9 kg/m2 and 71% presented with a comorbidity. Regression analysis exhibited an association between post menopause and the histological type associated with lower overall survival (OS), namely leiomyosarcoma or carcinosarcoma (odds ratio, 5.45, P<0.001). Stage I malignancy was present in 44% and Stage IV in 22%. The treatment included primary surgery in 78% of the cases, whereas 79% received adjuvant therapy. Only 55 cases achieved disease control and 20 relapsed (36%) with a 5‑year OS rate of 33%. The OS was lower for carcinosarcoma and leiomyosarcoma (20%; P=0.003). In summary, the present study indicated that the number of uterine sarcoma cases had increased between 2001 and 2016. The majority of the women were >60 years old and diagnosed in advanced stages. The postmenopausal status was associated with histological types of poor prognosis. The OS was low and worse for patients with carcinosarcoma and leiomyosarcoma.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

2 

Singh N and Gilks CB: The changing landscape of gynaecological cancer diagnosis: Implications for histopathological practice in the 21st century. Histopathology. 70:56–69. 2017.PubMed/NCBI View Article : Google Scholar

3 

Tropé CG, Abeler VM and Kristensen GB: Diagnosis and treatment of sarcoma of the uterus. A review. Acta Oncol. 51:694–705. 2012.PubMed/NCBI View Article : Google Scholar

4 

Ghirardi V, Bizzarri N, Guida F, Vascone C, Constantini B, Scambia G and Fagotti A: Role of surgery in gynaecological sarcomas. Oncotarget. 10:2561–2575. 2019.PubMed/NCBI View Article : Google Scholar

5 

Giuntoli RL 2nd, Metzinger DS, DiMarco CS, Cha SS, Sloan JA, Keeney GL and Gostout BS: Retrospective review of 208 patients with leiomyosarcoma of the uterus: Prognostic indicators, surgical management, and adjuvant therapy. Gynecol Oncol. 89:460–469. 2003.PubMed/NCBI View Article : Google Scholar

6 

Hoang L, Chiang S and Lee CH: Endometrial stromal sarcomas and related neoplasms: New developments and diagnostic considerations. Pathology. 50:162–177. 2018.PubMed/NCBI View Article : Google Scholar

7 

Kurman RJ, Carcangiu ML, Herrington CS and Young RH (eds): WHO Classification of Tumours of Female Reproductive Organs. 4th edition. IARC Press, Lyon, pp135-147, 2014.

8 

Oliva E: Cellular mesenchymal tumors of the uterus: A review emphasizing recent observations. Int J Gynecol Pathol. 33:374–384. 2014.PubMed/NCBI View Article : Google Scholar

9 

Prat J: FIGO staging for uterine sarcomas. Int J Gynaecol Obstet. 104:177–178. 2009.PubMed/NCBI View Article : Google Scholar

10 

Ueda SM, Kapp DS, Cheung MK, Shin JY, Osann K, Husain A, Teng NN, Berek JS and Chan JK: Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths. Am J Obstet Gynecol. 198(218)2008.PubMed/NCBI View Article : Google Scholar

11 

World Health Organization: International Statistical Classification of Diseases and Related Health Problems 10th Revision. ICD-10 version 2015. Available at: urihttps://icd.who.int/browse10/2015/ensimplehttps://icd.who.int/browse10/2015/en.

12 

FIGO Committee on Gynecologic Oncology. FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynecol Obstet. 125:97–98. 2014.PubMed/NCBI View Article : Google Scholar

13 

Koivisto-Korander R, Martinsen JI, Weiderpass E, Lemnen A and Pukkala E: Incidence of uterine leiomyosarcoma and endometrial stromal sarcoma in nordic countries: Results from NORDCAN and NOCCA databases. Maturitas. 72:56–60. 2012.PubMed/NCBI View Article : Google Scholar

14 

Mbatani N, Olawaiye EA and Prat J: Uterine sarcomas. Int J Gynecol Obstet. 143:51–58. 2018.PubMed/NCBI View Article : Google Scholar

15 

Felix AS, Cook LS, Gaudet MM, Rohan TE, Schouten LJ, Setiawan VW, Wise LA, Anderson KE, Bernstein L, De Vivo I, et al: The etiology of uterine sarcomas: A pooled analysis of the epidemiology of endometrial cancer consortium. Br J Cancer. 108:727–734. 2013.PubMed/NCBI View Article : Google Scholar

16 

Zhang YY, Li Y, Qin M, Cai Y, Jin Y and Pan LY: High-grade endometrial stromal sarcoma: A retrospective study of factors influencing prognosis. Cancer Manag Res. 11:831–837. 2019.PubMed/NCBI View Article : Google Scholar

17 

Ishidera Y, Yoshida H, Oi Y, Katayama K, Miyagi E, Hayashi H and Shigeta H: Analysis of uterine corporeal mesenchymal tumors occurring after menopause. BMC Women Health. 19(13)2019.PubMed/NCBI View Article : Google Scholar

18 

Koivisto-Korander R, Butzow R, Koivisto AM and Leminen A: Clinical outcome and prognostic factors in 100 cases of uterine sarcoma: Experience in helsinki university central hospital 1990-2001. Gynecol Oncol. 111:74–81. 2008.PubMed/NCBI View Article : Google Scholar

19 

Oliva E: Practical issues in uterine pathology from banal to bewildering: The remarkable spectrum of smooth muscle neoplasia. Mod Pathol. 29 (Suppl 1):S104–S120. 2016.PubMed/NCBI View Article : Google Scholar

20 

Burghaus S, Halmen S, Gass P, Mehlhorn G, Schrauder MG, Lux MP, Renner SP, Beckmann MW, Hein A and Thiel FC: Outcome and prognosis in uterine sarcoma and malignant mixed mullerian tumor. Arch Gynecol Obstet. 294:343–351. 2016.PubMed/NCBI View Article : Google Scholar

21 

Menczer J: Review of recommended treatment of uterine carcinoma. Curr Treat Options Oncol. 16(53)2015.PubMed/NCBI View Article : Google Scholar

22 

Nordal RR and Thoresen SO: Uterine sarcomas in Norway 1956-1992: Incidence, survival and mortality. Eur J Cancer. 33:907–911. 1997.PubMed/NCBI View Article : Google Scholar

23 

Zivanovic O, Leitao MM, Iasonos A, Jacks LM, Zhou Q, Abu-Rustum NR, Soslow RA, Juretzka MM, Chi DS, Barakat RR, et al: Stage-specific outcomes of patients with uterine leiomyosarcoma: A comparison of the international federation of gynecology and obstetrics and american joint committee on cancer staging systems. J Clin Oncol. 27:2066–2072. 2009.PubMed/NCBI View Article : Google Scholar

24 

Wada H, Enomoto T, Fujita M, Yoshino K, Nakashima R, Kurachi H, Haba T, Wakasa K, Shroyer KR, Tsujimoto M, et al: Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors. Cancer Res. 57:5379–5385. 1997.PubMed/NCBI

25 

Nusrath S, Bafna S, Rajagopalan R, Thammineedi SR, Raju KVV, Patnaik SC, Pawar S, Reddy Y, Chavali RN and Murthy SS: Uterine sarcomas: Experience from a tertiary cancer care center from India. Indian J Surg Oncol. 10:342–349. 2019.PubMed/NCBI View Article : Google Scholar

26 

Şükür YE, Taşkın S, Varlı B, Ateş C, Güngör M and Ortaç F: Prognostic factors for disease-free and overall survival of patients with uterine carcinosarcoma. Int J Clin Oncol. 23:114–120. 2018.PubMed/NCBI View Article : Google Scholar

27 

Bernard B, Clarke BA, Malowany JI, McAlpine J, Lee CH, Atenafu EG, Ferguson S and Mackay H: Uterine adenosarcomas: A dual-institution update on staging, prognosis and survival. Gynecol Oncol. 131:634–639. 2013.PubMed/NCBI View Article : Google Scholar

28 

Pietzner K, Buttmann-Schweiger N, Sehouli J and Kraywinkel K: Incidence patterns and survival of gynecological sarcoma in Germany: Analysis of population-based cancer registry data on 1066 women. Int J Gynecol Cancer. 28:134–138. 2018.PubMed/NCBI View Article : Google Scholar

29 

D'Angelo E and Prat J: Uterine sarcomas: A review. Gynecol Oncol. 116:131–139. 2010.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Plentz TB, Candido EC, Dias LF, Toledo MC, Vale DB and Teixeira JC: Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases. Mol Clin Oncol 13: 81, 2020.
APA
Plentz, T.B., Candido, E.C., Dias, L.F., Toledo, M.C., Vale, D.B., & Teixeira, J.C. (2020). Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases. Molecular and Clinical Oncology, 13, 81. https://doi.org/10.3892/mco.2020.2151
MLA
Plentz, T. B., Candido, E. C., Dias, L. F., Toledo, M. C., Vale, D. B., Teixeira, J. C."Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases". Molecular and Clinical Oncology 13.6 (2020): 81.
Chicago
Plentz, T. B., Candido, E. C., Dias, L. F., Toledo, M. C., Vale, D. B., Teixeira, J. C."Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases". Molecular and Clinical Oncology 13, no. 6 (2020): 81. https://doi.org/10.3892/mco.2020.2151
Copy and paste a formatted citation
x
Spandidos Publications style
Plentz TB, Candido EC, Dias LF, Toledo MC, Vale DB and Teixeira JC: Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases. Mol Clin Oncol 13: 81, 2020.
APA
Plentz, T.B., Candido, E.C., Dias, L.F., Toledo, M.C., Vale, D.B., & Teixeira, J.C. (2020). Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases. Molecular and Clinical Oncology, 13, 81. https://doi.org/10.3892/mco.2020.2151
MLA
Plentz, T. B., Candido, E. C., Dias, L. F., Toledo, M. C., Vale, D. B., Teixeira, J. C."Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases". Molecular and Clinical Oncology 13.6 (2020): 81.
Chicago
Plentz, T. B., Candido, E. C., Dias, L. F., Toledo, M. C., Vale, D. B., Teixeira, J. C."Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases". Molecular and Clinical Oncology 13, no. 6 (2020): 81. https://doi.org/10.3892/mco.2020.2151
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