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Oncoxin‑Viusid® may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments

  • Authors:
    • Mercedes Iveet Fundora Ramos
    • Lourdes Boulet Maden
    • Fernando Oriol Casanova
    • Frank Hernández Cruz
    • Carina Salgado Reyes
    • Adalberto Hernandez Gato
    • Israel Benítez Lyncon
    • Etna Vega González
    • Katia Palau Morales
    • Juan J. Lence
    • Eduardo Sanz
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hospital Universitario ‘General Calixto Garcia’, Havana CP10400, Cuba, Department of Urologic, Hospital Universitario ‘General Calixto Garcia’, Havana CP10400, Cuba, Department of Medical Imaging, Hospital Universitario ‘General Calixto Garcia’, Havana CP10400, Cuba, Department of Laboratory, Hospital Universitario ‘General Calixto Garcia’, Havana CP10400, Cuba, Department of Pharmacy, Hospital Universitario ‘General Calixto Garcia’, Havana CP10400, Cuba, Department of Biostatistics, Instituto Nacional de Oncología y Radiobiología, Havana CP10400, Cuba, Pharmaceutical Laboratory, Catalysis, S.L., 28016 Madrid, Spain
    Copyright: © Fundora Ramos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
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    Published online on: November 5, 2020
       https://doi.org/10.3892/mco.2020.2167
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Abstract

The aim of the present study was to identify the efficacy and safety of Oncoxin‑Viusid (OV) as a supportive treatment for patients with prostate cancer (PCA). A prospective, non‑randomised, open‑label phase II clinical trial, including 25 patients with hormone‑refractory PCA (HRPC) was conducted at the Hospital Universitario General Calixto García (Havana, Cuba) between June 2017 and March 2018. Each of the patients received chemotherapy (CTX) and/or radiotherapy (RT) and OV treatment. Patients had a mean age of 73 years, clinical stage IV cancer and a high risk of relapse. Six cycles of CTX were completed by 80% of the patients, adverse reactions decreased and no weight loss was observed. Among the 25 patients, 5 were lost to follow‑up and 4 died of disease progression. A total of 16 of these patients survived, of which 15 had an improved quality of life and 10 responded to treatment, with a significant reduction in pain and prostate symptoms and ≥50% reduction in baseline PSA. The progression‑free survival (PFS) rate was 59% and the overall survival (OS) rate 64% at 1 year after treatment began. The OV nutritional supplement was effective, leading to a significant improvement in the patients' quality of life, good nutritional status and greater treatment tolerance. A clinical and humoral response was observed, with high survival rates and a delayed appearance of signs of disease progression. The present study was registered in ClinicalTrials.gov PRS with ID #NCT03543670.
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Copy and paste a formatted citation
Spandidos Publications style
Fundora Ramos MI, Boulet Maden L, Oriol Casanova F, Hernández Cruz F, Salgado Reyes C, Hernandez Gato A, Benítez Lyncon I, Vega González E, Palau Morales K, Lence JJ, Lence JJ, et al: Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments. Mol Clin Oncol 14: 5, 2021.
APA
Fundora Ramos, M.I., Boulet Maden, L., Oriol Casanova, F., Hernández Cruz, F., Salgado Reyes, C., Hernandez Gato, A. ... Sanz, E. (2021). Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments. Molecular and Clinical Oncology, 14, 5. https://doi.org/10.3892/mco.2020.2167
MLA
Fundora Ramos, M. I., Boulet Maden, L., Oriol Casanova, F., Hernández Cruz, F., Salgado Reyes, C., Hernandez Gato, A., Benítez Lyncon, I., Vega González, E., Palau Morales, K., Lence, J. J., Sanz, E."Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments". Molecular and Clinical Oncology 14.1 (2021): 5.
Chicago
Fundora Ramos, M. I., Boulet Maden, L., Oriol Casanova, F., Hernández Cruz, F., Salgado Reyes, C., Hernandez Gato, A., Benítez Lyncon, I., Vega González, E., Palau Morales, K., Lence, J. J., Sanz, E."Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments". Molecular and Clinical Oncology 14, no. 1 (2021): 5. https://doi.org/10.3892/mco.2020.2167
Copy and paste a formatted citation
x
Spandidos Publications style
Fundora Ramos MI, Boulet Maden L, Oriol Casanova F, Hernández Cruz F, Salgado Reyes C, Hernandez Gato A, Benítez Lyncon I, Vega González E, Palau Morales K, Lence JJ, Lence JJ, et al: Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments. Mol Clin Oncol 14: 5, 2021.
APA
Fundora Ramos, M.I., Boulet Maden, L., Oriol Casanova, F., Hernández Cruz, F., Salgado Reyes, C., Hernandez Gato, A. ... Sanz, E. (2021). Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments. Molecular and Clinical Oncology, 14, 5. https://doi.org/10.3892/mco.2020.2167
MLA
Fundora Ramos, M. I., Boulet Maden, L., Oriol Casanova, F., Hernández Cruz, F., Salgado Reyes, C., Hernandez Gato, A., Benítez Lyncon, I., Vega González, E., Palau Morales, K., Lence, J. J., Sanz, E."Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments". Molecular and Clinical Oncology 14.1 (2021): 5.
Chicago
Fundora Ramos, M. I., Boulet Maden, L., Oriol Casanova, F., Hernández Cruz, F., Salgado Reyes, C., Hernandez Gato, A., Benítez Lyncon, I., Vega González, E., Palau Morales, K., Lence, J. J., Sanz, E."Oncoxin‑Viusid<sup>&reg;</sup> may improve quality of life and survival in patients with hormone‑refractory prostate cancer undergoing onco‑specific treatments". Molecular and Clinical Oncology 14, no. 1 (2021): 5. https://doi.org/10.3892/mco.2020.2167
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