Open Access

Integrity of plasma cell‑free DNA as a prognostic factor for vaccine therapy in patients with endometrial cancer

  • Authors:
    • Kayoko Waki
    • Kanako Yokomizo
    • Kouichiro Kawano
    • Naotake Tsuda
    • Nobukazu Komatsu
    • Akira Yamada
  • View Affiliations

  • Published online on: December 16, 2020     https://doi.org/10.3892/mco.2020.2191
  • Article Number: 29
  • Copyright: © Waki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endometrial cancer is the most prevalent gynecological cancer in developed countries. Although the prognosis of endometrial cancer is better than that of other gynecological cancers, the prognosis of advanced endometrial cancer is still poor and thus new therapeutic modalities, such as immune therapies, are urgently required. For the further development of new modalities, exploration of new biomarkers is important. The present study investigated the circulating cell‑free DNA (cfDNA) integrity as a ratio of the necrotic tumor cell‑derived long cfDNA fragments to the total dead cell‑derived short cfDNA fragments from genomic Alu elements in patients with advanced endometrial cancer during peptide vaccination treatment. The results demonstrated that: i) The plasma cfDNA integrity was decreased during the first cycle of vaccination in patients with endometrial cancer treated with the personalized peptide vaccination, and ii) the post‑vaccination cfDNA integrity levels were correlated with good prognosis. Some of these findings have been confirmed in other cancers, and thus cfDNA integrity might be an important marker for future cancer vaccine therapies in general, and might also be applicable for other immune therapies.
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February-2021
Volume 14 Issue 2

Print ISSN: 2049-9450
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Spandidos Publications style
Waki K, Yokomizo K, Kawano K, Tsuda N, Komatsu N and Yamada A: Integrity of plasma cell‑free DNA as a prognostic factor for vaccine therapy in patients with endometrial cancer. Mol Clin Oncol 14: 29, 2021
APA
Waki, K., Yokomizo, K., Kawano, K., Tsuda, N., Komatsu, N., & Yamada, A. (2021). Integrity of plasma cell‑free DNA as a prognostic factor for vaccine therapy in patients with endometrial cancer. Molecular and Clinical Oncology, 14, 29. https://doi.org/10.3892/mco.2020.2191
MLA
Waki, K., Yokomizo, K., Kawano, K., Tsuda, N., Komatsu, N., Yamada, A."Integrity of plasma cell‑free DNA as a prognostic factor for vaccine therapy in patients with endometrial cancer". Molecular and Clinical Oncology 14.2 (2021): 29.
Chicago
Waki, K., Yokomizo, K., Kawano, K., Tsuda, N., Komatsu, N., Yamada, A."Integrity of plasma cell‑free DNA as a prognostic factor for vaccine therapy in patients with endometrial cancer". Molecular and Clinical Oncology 14, no. 2 (2021): 29. https://doi.org/10.3892/mco.2020.2191