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Article

PGC1α and VDAC1 expression in endometrial cancer

  • Authors:
    • Ofra Castro Wersäll
    • Lina Löfstedt
    • Igor Govorov
    • Miriam Mints
    • Marike Gabrielson
    • Maria Shoshan
  • View Affiliations / Copyright

    Affiliations: Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institute, Stockholm 171 77, Sweden, Department of Oncology‑Pathology, BioClinicum, Karolinska Institute, Solna 171 64, Sweden
  • Article Number: 42
    |
    Published online on: December 30, 2020
       https://doi.org/10.3892/mco.2020.2203
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Abstract

Endometrial cancer (EC) is one of the ten most common gynecological cancers. As in most cancers, EC tumour progression involves alterations in cellular metabolism and can be associated with, for instance, altered levels of glycolytic enzymes. Mitochondrial functions and proteins are known to serve key roles in tumour metabolism and progression. The transcriptional coactivator peroxisome proliferator‑activated receptor gamma coactivator 1 (PGC1α) is a major regulator of mitochondrial biogenesis and function, albeit of varying prognostic value in different cancers. The voltage‑dependent anion channel type 1 (VDAC1) regulates apoptosis as well as metabolite import and export over the mitochondrial outer membrane, and is often used for comparative quantification of mitochondrial content. Using immunohistochemistry, the present study examined protein expression levels of PGC1α and VDAC1 in tumour and paired benign tissue samples from 148 patients with EC, in order to examine associations with clinical data, such as stage and grade, Ki‑67, p53 status, clinical resistance and overall survival. The expression levels of both PGC1α and VDAC1, as well as a PGC1α downstream effector, were significantly lower in tumor tissues than in benign tissues, suggesting altered mitochondrial function in EC. However, Kaplan‑Meier, log rank and Spearman's rank correlation tests revealed that their expression was not correlated with survival and clinical data. Therefore, PGC1α and VDAC1 are not of major prognostic value in EC.
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Copy and paste a formatted citation
Spandidos Publications style
Castro Wersäll O, Löfstedt L, Govorov I, Mints M, Gabrielson M and Shoshan M: PGC1α and VDAC1 expression in endometrial cancer. Mol Clin Oncol 14: 42, 2021.
APA
Castro Wersäll, O., Löfstedt, L., Govorov, I., Mints, M., Gabrielson, M., & Shoshan, M. (2021). PGC1α and VDAC1 expression in endometrial cancer. Molecular and Clinical Oncology, 14, 42. https://doi.org/10.3892/mco.2020.2203
MLA
Castro Wersäll, O., Löfstedt, L., Govorov, I., Mints, M., Gabrielson, M., Shoshan, M."PGC1α and VDAC1 expression in endometrial cancer". Molecular and Clinical Oncology 14.2 (2021): 42.
Chicago
Castro Wersäll, O., Löfstedt, L., Govorov, I., Mints, M., Gabrielson, M., Shoshan, M."PGC1α and VDAC1 expression in endometrial cancer". Molecular and Clinical Oncology 14, no. 2 (2021): 42. https://doi.org/10.3892/mco.2020.2203
Copy and paste a formatted citation
x
Spandidos Publications style
Castro Wersäll O, Löfstedt L, Govorov I, Mints M, Gabrielson M and Shoshan M: PGC1α and VDAC1 expression in endometrial cancer. Mol Clin Oncol 14: 42, 2021.
APA
Castro Wersäll, O., Löfstedt, L., Govorov, I., Mints, M., Gabrielson, M., & Shoshan, M. (2021). PGC1α and VDAC1 expression in endometrial cancer. Molecular and Clinical Oncology, 14, 42. https://doi.org/10.3892/mco.2020.2203
MLA
Castro Wersäll, O., Löfstedt, L., Govorov, I., Mints, M., Gabrielson, M., Shoshan, M."PGC1α and VDAC1 expression in endometrial cancer". Molecular and Clinical Oncology 14.2 (2021): 42.
Chicago
Castro Wersäll, O., Löfstedt, L., Govorov, I., Mints, M., Gabrielson, M., Shoshan, M."PGC1α and VDAC1 expression in endometrial cancer". Molecular and Clinical Oncology 14, no. 2 (2021): 42. https://doi.org/10.3892/mco.2020.2203
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