Durable response achieved using Pazopanib for germ tumor cells: A case report

  • Authors:
    • Yuta Takezawa
    • Hiroshi Yaegashi
    • Masashi Iijima
    • Shohei  Kawaguchi
    • Takahiro Nohara
    • Kazuyoshi Shigehara
    • Kouji Izumi
    • Yoshihumi  Kadono
    • Hiroko Ikeda
    • Atsushi Mizokami
  • View Affiliations

  • Published online on: January 19, 2021     https://doi.org/10.3892/mco.2021.2210
  • Article Number: 48
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Abstract

Germ cell tumors with somatic‑type malignancy (GCTSTM) are rare, and patients with GCTSTM have extremely poor prognoses with a median survival of nine months. Somatic‑type malignancy, which are mainly sarcomas, usually exhibit chemoresistance. The recommended therapy for GCTSTM is radical resection; however, Pazopanib, which is a multityrosine kinase inhibitor, has indicated therapeutic effects for some soft tissue sarcoma components. The current study reports the case of a 21‑year‑old Asian man who presented with GCTSTM after combined chemotherapy for a primary mediastinal germ cell tumor with multiple lung metastases. Despite the metastases, his disease was stable after continuous administration of Pazopanib for two years and then stopping the medication for four years. To the best of our knowledge, the current report is the first report of a durable response by Pazopanib for GCTSTM, which is a rare outcome.
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March-2021
Volume 14 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Takezawa Y, Yaegashi H, Iijima M, Kawaguchi S, Nohara T, Shigehara K, Izumi K, Kadono Y, Ikeda H, Mizokami A, Mizokami A, et al: Durable response achieved using Pazopanib for germ tumor cells: A case report. Mol Clin Oncol 14: 48, 2021
APA
Takezawa, Y., Yaegashi, H., Iijima, M., Kawaguchi, S., Nohara, T., Shigehara, K. ... Mizokami, A. (2021). Durable response achieved using Pazopanib for germ tumor cells: A case report. Molecular and Clinical Oncology, 14, 48. https://doi.org/10.3892/mco.2021.2210
MLA
Takezawa, Y., Yaegashi, H., Iijima, M., Kawaguchi, S., Nohara, T., Shigehara, K., Izumi, K., Kadono, Y., Ikeda, H., Mizokami, A."Durable response achieved using Pazopanib for germ tumor cells: A case report". Molecular and Clinical Oncology 14.3 (2021): 48.
Chicago
Takezawa, Y., Yaegashi, H., Iijima, M., Kawaguchi, S., Nohara, T., Shigehara, K., Izumi, K., Kadono, Y., Ikeda, H., Mizokami, A."Durable response achieved using Pazopanib for germ tumor cells: A case report". Molecular and Clinical Oncology 14, no. 3 (2021): 48. https://doi.org/10.3892/mco.2021.2210