Safety of same‑day administration of gemcitabine plus cisplatin chemotherapy for urothelial carcinoma

  • Authors:
    • Ibuki Tsuru
    • Fusako Niimi
    • Sachi Honda
    • Takeshi Azuma
  • View Affiliations

  • Published online on: January 22, 2021     https://doi.org/10.3892/mco.2021.2219
  • Article Number: 57
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Abstract

The present study aimed to examine the safety of a gemcitabine and cisplatin (GC) combination chemotherapy regimen with short hydration for the treatment of urothelial cancer administered on the same day (same day regimen). Patients with locally advanced or metastatic urothelial cancer received the same‑day GC regimen with short hydration every 4 weeks, and their serum creatinine (Cr) level was measured to assess renal function using linear mixed model analysis. A total of 20 patients receiving the same‑day regimen exhibited no significant change in their serum Cr level; nor was there any significant change in the serum Cr level between patients who received the same day regimen and those who received the drugs on different days. The present study demonstrated that the same‑day regimen was safe for patients with urothelial cancer.
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March-2021
Volume 14 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Tsuru I, Niimi F, Honda S and Azuma T: Safety of same‑day administration of gemcitabine plus cisplatin chemotherapy for urothelial carcinoma. Mol Clin Oncol 14: 57, 2021
APA
Tsuru, I., Niimi, F., Honda, S., & Azuma, T. (2021). Safety of same‑day administration of gemcitabine plus cisplatin chemotherapy for urothelial carcinoma. Molecular and Clinical Oncology, 14, 57. https://doi.org/10.3892/mco.2021.2219
MLA
Tsuru, I., Niimi, F., Honda, S., Azuma, T."Safety of same‑day administration of gemcitabine plus cisplatin chemotherapy for urothelial carcinoma". Molecular and Clinical Oncology 14.3 (2021): 57.
Chicago
Tsuru, I., Niimi, F., Honda, S., Azuma, T."Safety of same‑day administration of gemcitabine plus cisplatin chemotherapy for urothelial carcinoma". Molecular and Clinical Oncology 14, no. 3 (2021): 57. https://doi.org/10.3892/mco.2021.2219