Electrochemotherapy in Kaposi sarcoma: A systematic review

Ferioli,Martina; Galuppi,Andrea; Buwenge,Milly; Cammelli,Silvia; Perrone,Anna  Myriam; Macchia,Gabriella; Deodato,Francesco; Cilla,Savino; Zamagni,Alice; De Terlizzi,Francesca; Tagliaferri,Luca; De Iaco,Pierandrea; Morganti,Alessio Giuseppe

doi:10.3892/mco.2021.2226

April-2021 Volume 14 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April-2021 Volume 14 Issue 4

Full Size Image

Article

Electrochemotherapy in Kaposi sarcoma: A systematic review

Authors:
- Martina Ferioli
- Andrea Galuppi
- Milly Buwenge
- Silvia Cammelli
- Anna Myriam Perrone
- Gabriella Macchia
- Francesco Deodato
- Savino Cilla
- Alice Zamagni
- Francesca De Terlizzi
- Luca Tagliaferri
- Pierandrea De Iaco
- Alessio Giuseppe Morganti
View Affiliations / Copyright

Affiliations: Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine‑DIMES, University of Bologna, I‑40138 Bologna, Italy, Oncologic Gynaecology Unit, Department Medical and Surgical Sciences (DIMEC), University of Bologna, S. Orsola‑Malpighi Hospital, I‑40138 Bologna, Italy, Radiotherapy Unit, Gemelli Molise Hospital, Fondazione Policlinico Universitario A. Gemelli, IRCCS, I‑86100 Campobasso, Italy, MedicalPhysic Unit, Gemelli Molise Hospital, Fondazione Policlinico Universitario A. Gemelli, IRCCS, I‑86100 Campobasso, Italy, Scientific and Medical Department IGEA S.p.A., I‑41012 Carpi (Mo), Italy, Fondazione Policlinico Universitario ‘A. Gemelli’ IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, I‑00168 Roma, Italy
Article Number: 64
|
Published online on: February 8, 2021

https://doi.org/10.3892/mco.2021.2226
Expand metrics +

Abstract

Kaposi sarcoma (KS) is a rare angioproliferative disorder, which is usually associated with human herpesvirus‑8 infection. Electrochemotherapy (ECT) may be an option in the treatment of KS skin lesions due to the high response rate noted in neoplastic lesions of different histological types. The aim of the present systematic review was to analyse the available evidence on using ECT in the treatment of KS skin lesions. Tumor response, local control and toxicity were analyzed. In the three included studies, the complete response rate was 65‑100% and the overall response rate in all studies was 100%. The treatment was well tolerated with mild and transient toxicity. However, further studies are required to fully analyze long‑term disease control and to compare ECT with other local therapies used for KS.

View Figures

View References

1	Ruocco E, Ruocco V, Tornesello ML, Gambardella A, Wolf R and Buonaguro FM: Kaposi's sarcoma: Etiology and pathogenesis, inducing factors, causal associations, and treatments: Facts and controversies. Clin Dermatol. 31:413–422. 2013.PubMed/NCBI View Article : Google Scholar
2	Schneider JW and Dittmer DP: Diagnosis and treatment of Kaposi sarcoma. Am J Clin Dermatol. 18:529–539. 2017.PubMed/NCBI View Article : Google Scholar
3	Lebbe C, Garbe C, Stratigos AJ, Harwood C, Peris K, Marmol VD, Malvehy J, Zalaudek I, Hoeller C, Dummer R, et al: Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC). Eur J Cancer. 114:117–127. 2019.PubMed/NCBI View Article : Google Scholar
4	Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, Billard V, Geertsen PF, Larkin JO, Miklavcic D, et al: Electrochemothrapy, an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European standard operating procedures of electrochemotherapy) study. Eur J Cancer Suppl. 4:3–13. 2006.
5	Cadossi R, Ronchetti M and Cadossi M: Locally enhanced chemotherapy by electroporation: Clinical experiences and perspective of use of electrochemotherapy. Future Oncol. 10:877–890. 2014.PubMed/NCBI View Article : Google Scholar
6	Sersa G, Miklavcic D, Cemazar M, Rudolf Z, Pucihar G and Snoj M: Electrochemotherapy in treatment of tumours. Eur J Surg Oncol. 34:232–240. 2008.PubMed/NCBI View Article : Google Scholar
7	Esmaeili N and Friebe M: Electrochemotherapy: A review of current status, alternative IGP approaches, and future perspectives. J Healthc Eng. 2019(2784516)2019.PubMed/NCBI View Article : Google Scholar
8	Cemazar M, Parkins CS, Holder AL, Chaplin DJ, Tozer GM and Sersa G: Electroporation of human microvascular endothelial cells: Evidence for an anti-vascular mechanism of electrochemotherapy. Br J Cancer. 84:565–570. 2001.PubMed/NCBI View Article : Google Scholar
9	Centre for Reviews and Dissemination, University of York. PROSPERO: International Prospective Register of Systematic Reviews. https://www.crd.york.ac.uk/prospero. Accessed October 1, 2019.
10	Moher D, Liberati A, Tetzlaff J and Altman DG: PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. J Clin Epidemiol. 62:1006–1012. 2009.PubMed/NCBI View Article : Google Scholar
11	Curatolo P, Quaglino P, Marenco F, Mancini M, Nardò T, Mortera C, Rotunno R, Calvieri S and Bernengo MG: Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: A two-center prospective phase II trial. Ann Surg Oncol. 19:192–198. 2012.PubMed/NCBI View Article : Google Scholar
12	Latini A, Bonadies A, Trento E, Bultrini S, Cota C, Solivetti FM, Ferraro C, Ardigò M, Amorosi B, Palamara G, et al: Effective treatment of Kaposi's sarcoma by electrochemotherapy and intravenous bleomycin administration. Dermatol Ther. 25:214–218. 2012.PubMed/NCBI View Article : Google Scholar
13	Starita N, Di Monta G, Cerasuolo A, Marone U, Anniciello AM, Botti G, Buonaguro L, Buonaguro FM and Tornesello ML: Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma. Infect Agent Cancer. 12(35)2017.PubMed/NCBI View Article : Google Scholar
14	Pincus T, Bergman M, Sokka T, Roth J, Swearingen C and Yazici Y: Visual analog scales in formats other than a 10 centimeter horizontal line to assess pain and other clinical data. J Rheumatol. 35:1550–1558. 2008.PubMed/NCBI
15	Stelzer KJ and Griffin TW: A randomized prospective trial of radiation therapy for AIDS-associated Kaposi's sarcoma. Int J Radiat Oncol Biol Phys. 27:1057–1061. 1993.PubMed/NCBI View Article : Google Scholar
16	Caccialanza M, Marca S, Piccinno R and Eulisse G: Radiotherapy of classic and human immunodeficiency virus-related Kaposi's sarcoma: Results in 1482 lesions. J Eur Acad Dermatol Venereol. 22:297–302. 2008.PubMed/NCBI View Article : Google Scholar
17	Hamilton CR, Cumming BJ and Harwood AR: Radiotherapy of Kaposi's sarcoma. Int J Radiat Oncol Biol Phys. 12:1931–1935. 1986.PubMed/NCBI View Article : Google Scholar
18	Fort M, Guet S, Colson-Durand L, Auzolle C and Belkacemi Y: Role of radiation therapy in non-melanoma cancers, lymphomas and sarcomas of the skin: Systematic review and best practice in 2016. Crit Rev Oncol Hematol. 99:200–213. 2016.PubMed/NCBI View Article : Google Scholar
19	GLOBOCAN. 2018, Cancer Incidence and Mortality Worldwide: IARC CancerBase. Lyon, France: International Agency for Research on Cancer. http://gco.iarc.fr/today/data/factsheets/populations/991-who-africa-region-afro-fact-sheets.pdf. Accessed April 20, 2020.
20	Boudreaux AA, Smith LL, Cosby CD, Bason MM, Tappero JW and Berger TG: Intralesional vinblastine for cutaneous Kaposi's sarcoma associated with acquired immunodeficiency syndrome. A clinical trial to evaluate efficacy and discomfort associated with infection. J Am Acad Dermatol. 28:61–65. 1993.PubMed/NCBI View Article : Google Scholar
21	Brambilla L, Bellinvia M, Tourlaki A, Scoppio B, Gaiani F and Boneschi V: Intralesional vincristine as first-line therapy for nodular lesions in classic Kaposi sarcoma: A prospective study in 151 patients. Br J Dermatol. 162:854–859. 2010.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Electrochemotherapy in Kaposi sarcoma: A systematic review

This article is mentioned in:

Abstract

Figure 1

Related Articles