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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report Open Access

Secondary CIC‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report

  • Authors:
    • Shiro Kimbara
    • Yoshinori Imamura
    • Naomi Kiyota
    • Hidetomo Takakura
    • Sakuya Matsumoto
    • Taiji Koyama
    • Yoshimi Fujishima
    • Yohei Funakoshi
    • Masanori Toyoda
    • Takanori Hirose
    • Maki Kanzawa
    • Teruya Kawamoto
    • Hitomi Hara
    • Hironobu Minami
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology/Hematology, Kobe University Hospital, Kobe, Hyogo 650‑0017, Japan, Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Hyogo 650‑0017, Japan, Department of Orthopaedic Surgery, Kobe University Hospital, Kobe, Hyogo 650‑0017, Japan
    Copyright: © Kimbara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 68
    |
    Published online on: February 8, 2021
       https://doi.org/10.3892/mco.2021.2230
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Abstract

Capicua transcriptional repressor (CIC)‑rearranged sarcoma is an Ewing‑like sarcoma with an aggressive clinical course and poor prognosis. No standard treatment has been established. The present study describes a case of CIC‑rearranged sarcoma with lung metastases developing in a 24‑year‑old woman as a therapy‑associated malignancy following chemotherapy for anaplastic large cell lymphoma at nine years old. This was treated with palliative regimens used for Ewing sarcoma. The patient achieved disease control for one year. Of note, ifosfamide and etoposide (IE), which were used as a second line treatment lead to a partial response. The case described in the present study indicated that treatment with Ewing regimens is a reasonable option for patients with metastatic CIC‑rearranged sarcoma, including those with a second malignant case.
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Copy and paste a formatted citation
Spandidos Publications style
Kimbara S, Imamura Y, Kiyota N, Takakura H, Matsumoto S, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Hirose T, Hirose T, et al: Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report. Mol Clin Oncol 14: 68, 2021.
APA
Kimbara, S., Imamura, Y., Kiyota, N., Takakura, H., Matsumoto, S., Koyama, T. ... Minami, H. (2021). Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report. Molecular and Clinical Oncology, 14, 68. https://doi.org/10.3892/mco.2021.2230
MLA
Kimbara, S., Imamura, Y., Kiyota, N., Takakura, H., Matsumoto, S., Koyama, T., Fujishima, Y., Funakoshi, Y., Toyoda, M., Hirose, T., Kanzawa, M., Kawamoto, T., Hara, H., Minami, H."Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report". Molecular and Clinical Oncology 14.4 (2021): 68.
Chicago
Kimbara, S., Imamura, Y., Kiyota, N., Takakura, H., Matsumoto, S., Koyama, T., Fujishima, Y., Funakoshi, Y., Toyoda, M., Hirose, T., Kanzawa, M., Kawamoto, T., Hara, H., Minami, H."Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report". Molecular and Clinical Oncology 14, no. 4 (2021): 68. https://doi.org/10.3892/mco.2021.2230
Copy and paste a formatted citation
x
Spandidos Publications style
Kimbara S, Imamura Y, Kiyota N, Takakura H, Matsumoto S, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Hirose T, Hirose T, et al: Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report. Mol Clin Oncol 14: 68, 2021.
APA
Kimbara, S., Imamura, Y., Kiyota, N., Takakura, H., Matsumoto, S., Koyama, T. ... Minami, H. (2021). Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report. Molecular and Clinical Oncology, 14, 68. https://doi.org/10.3892/mco.2021.2230
MLA
Kimbara, S., Imamura, Y., Kiyota, N., Takakura, H., Matsumoto, S., Koyama, T., Fujishima, Y., Funakoshi, Y., Toyoda, M., Hirose, T., Kanzawa, M., Kawamoto, T., Hara, H., Minami, H."Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report". Molecular and Clinical Oncology 14.4 (2021): 68.
Chicago
Kimbara, S., Imamura, Y., Kiyota, N., Takakura, H., Matsumoto, S., Koyama, T., Fujishima, Y., Funakoshi, Y., Toyoda, M., Hirose, T., Kanzawa, M., Kawamoto, T., Hara, H., Minami, H."Secondary <em>CIC</em>‑rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report". Molecular and Clinical Oncology 14, no. 4 (2021): 68. https://doi.org/10.3892/mco.2021.2230
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