Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-2021 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification

  • Authors:
    • Kensuke Tajiri
    • Tomoya Sudo
    • Kazuo Ishi
    • Akihiko Kawahara
    • Sachiko Nagasu
    • Susumu Shimomura
    • Kotaro Yuge
    • Mitsuhiro Katagiri
    • Takato Yomoda
    • Kenji Fujiyoshi
    • Koshi Kenichi
    • Takafumi Ohchi
    • Takefumi Yoshida
    • Tomoaki Mizobe
    • Fumihiko Fujita
    • Jun Akiba
    • Yoshito Akagi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan, Biostatistics Center, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan, Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan
    Copyright: © Tajiri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 98
    |
    Published online on: March 12, 2021
       https://doi.org/10.3892/mco.2021.2260
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Signet ring cell carcinoma (SRCC) is a rare pathological type of colorectal cancer, of which the clinicopathological features and genetic background have not yet been fully investigated. Previous research has focused on the optimization of colorectal cancer treatment utilizing consensus molecular subtyping (CMS). However, it is not known what type of CMS would be designated to SRCC treatment. In the current study, of 1,350 patients diagnosed with colorectal cancer who underwent surgery, 14 were diagnosed with SRCC. The case‑control cohort that fit the clinical background of the SRCC case was constructed. Statistical comparison between the SRCC group and the case‑control cohort was performed among clinicopathological variables. SRCC and well to moderately adenocarcinoma case mRNA were submitted to microarray analysis and CMS analysis. Compared with the case‑control cohort, the SRCC group was located more in the right‑sided colon, the lymphatic invasion was more severe and the peritoneal dissemination was more frequent. The cancer‑specific survival and the progression‑free survival were significantly worse in the SRCC group compared with the case‑control cohort. Microarray and CMS analysis identified that one SRCC case was significantly well assigned in the CMS 4 group and the other case was assigned in the CMS 1 group. Gene set analysis revealed the upregulation of EMT related genes and the downregulation of fatty acid, glycolysis, differentiation, MYC, HNF4A, DNA repair genes. In conclusion, the clinical characteristics of SRCC are severe but there is a possibility of the presence of different phenotypes according to CMS analysis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Arifi S, Elmesbahi O and Amarti Riffi A: Primary signet ring cell carcinoma of the colon and rectum. Bull Cancer. 102:880–888. 2015.PubMed/NCBI View Article : Google Scholar

2 

Fu J, Wu L, Jiang M, Tan Y, Li D, Chen F, Jiang T and Du J: Signet ring cell carcinoma of resectable metastatic colorectal cancer has rare surgical value. J Surg Oncol. 114:1004–1008. 2016.PubMed/NCBI View Article : Google Scholar

3 

Cabibi D, Calascibetta A, Aragona F, Martorana A, Campione M and Sanguedolce R: Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma. Anticancer Res. 29:4417–4422. 2009.PubMed/NCBI

4 

Bellan A, Cappellesso R, Lo Mele M, Peraro L, Balsamo L, Lanza C, Fassan M and Rugge M: Early signet ring cell carcinoma arising from colonic adenoma: The molecular profiling supports the adenoma-carcinoma sequence. Hum Pathol. 50:183–186. 2016.PubMed/NCBI View Article : Google Scholar

5 

Wistuba II, Behrens C, Albores-Saavedra J, Delgado R, Lopez F and Gazdar AF: Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma. Clin Cancer Res. 9:3615–3619. 2003.PubMed/NCBI

6 

Korphaisarn K, Morris V, Davis JS, Overman MJ, Fogelman DR, Kee BK, Dasari A, Raghav KPS, Shureiqi I, Trupti M, et al: Signet ring cell colorectal cancer: Genomic insights into a rare subpopulation of colorectal adenocarcinoma. Br J Cancer. 121:505–510. 2019.PubMed/NCBI View Article : Google Scholar

7 

Liang Z, Yan D, Li G and Cheng H: Clinical analysis of primary colorectal signet-ring cell carcinoma. Clin Colorectal Cancer. 17:e39–e44. 2018.PubMed/NCBI View Article : Google Scholar

8 

Nitsche U, Friess H, Agha A, Angele M, Eckel R, Heitland W, Jauch KW, Krenz D, Nüssler NC, Rau HG, et al: Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort. J Cancer Res Clin Oncol. 142:2357–2366. 2016.PubMed/NCBI View Article : Google Scholar

9 

Börger ME, Gosens MJ, Jeuken JW, van Kempen LC, van de Velde CJ, van Krieken JH and Nagtegaal ID: Signet ring cell differentiation in mucinous colorectal carcinoma. J Pathol. 212:278–286. 2007.PubMed/NCBI View Article : Google Scholar

10 

Chen JS, Hsieh PS, Chiang JM, Yeh CY, Tsai WS, Tang R, Changchien CR and Wu RC: Clinical outcome of signet ring cell carcinoma and mucinous adenocarcinoma of the colon. Chang Gung Med J. 33:51–57. 2010.PubMed/NCBI

11 

Hyngstrom JR, Hu CY, Xing Y, You YN, Feig BW, Skibber JM, Rodriguez-Bigas MA, Cormier JN and Chang GJ: Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: Analysis from the national cancer data base. Ann Surg Oncol. 19:2814–2821. 2012.PubMed/NCBI View Article : Google Scholar

12 

Song IH, Hong SM, Yu E, Yoon YS, Park IJ, Lim SB, Kim JC, Yu CS and Kim J: Signet ring cell component predicts aggressive behaviour in colorectal mucinous adenocarcinoma. Pathology. 51:384–391. 2019.PubMed/NCBI View Article : Google Scholar

13 

Fukata K, Yuasa N, Takeuchi E, Miyake H, Nagai H, Yoshioka Y and Miyata K: Clinical and prognostic differences between surgically resected right-sided and left-sided colorectal cancer. Surg Today. 50:267–274. 2020.PubMed/NCBI View Article : Google Scholar

14 

Anthony T, George R, Rodriguez-Bigas M and Petrelli NJ: Primary signet-ring cell carcinoma of the colon and rectum. Ann Surg Oncol. 3:344–348. 1996.PubMed/NCBI View Article : Google Scholar

15 

Bae JM, Kim MJ, Kim JH, Koh JM, Cho NY, Kim TY and Kang GH: Differential clinicopathological features in microsatellite instability-positive colorectal cancers depending on CIMP status. Virchows Arch. 459:55–63. 2011.PubMed/NCBI View Article : Google Scholar

16 

Alvi MA, Loughrey MB, Dunne P, McQuaid S, Turkington R, Fuchs MA, McGready C, Bingham V, Pang B, Moore W, et al: Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies. Br J Cancer. 117:203–209. 2017.PubMed/NCBI View Article : Google Scholar

17 

Tajiri K, Sudou T, Fujita F, Hisaka T, Kinugasa T and Akagi Y: Clinicopathological and corresponding genetic features of colorectal signet ring cell carcinoma. Anticancer Res. 37:3817–3823. 2017.PubMed/NCBI View Article : Google Scholar

18 

Yalcin S and Onguru O: BRAF mutation in colorectal carcinomas with signet ring cell component. Cancer Biol Med. 14:287–292. 2017.PubMed/NCBI View Article : Google Scholar

19 

Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, et al: The consensus molecular subtypes of colorectal cancer. Nat Med. 21:1350–1356. 2015.PubMed/NCBI View Article : Google Scholar

20 

Lenz HJ, Ou FS, Venook AP, Hochster HS, Niedzwiecki D, Goldberg RM, Mayer RJ, Bertagnolli MM, Blanke CD, Zemla T, et al: Impact of consensus molecular subtype on survival in patients with metastatic colorectal cancer: Results from CALGB/SWOG 80405 (Alliance). J Clin Oncol. 37:1876–1885. 2019.PubMed/NCBI View Article : Google Scholar

21 

Stintzing S, Wirapati P, Lenz HJ, Neureiter D, Fischer von Weikersthal L, Decker T, Kiani A, Kaiser F, Al-Batran S, Heintges T, et al: Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial. Ann Oncol. 30:1796–1803. 2019.PubMed/NCBI View Article : Google Scholar

22 

Mooi JK, Wirapati P, Asher R, Lee CK, Savas P, Price TJ, Townsend A, Hardingham J, Buchanan D, Williams D, et al: The prognostic impact of consensus molecular subtypes (CMS) and its predictive effects for bevacizumab benefit in metastatic colorectal cancer: Molecular analysis of the AGITG MAX clinical trial. Ann Oncol. 29:2240–2246. 2018.PubMed/NCBI View Article : Google Scholar

23 

Eide PW, Bruun J, Lothe RA and Sveen A: CMScaller: An R package for consensus molecular subtyping of colorectal cancer pre-clinical models. Sci Rep. 7(16618)2017.PubMed/NCBI View Article : Google Scholar

24 

Almagro UA: Primary signet-ring carcinoma of the colon. Cancer. 52:1453–1457. 1983.PubMed/NCBI View Article : Google Scholar

25 

Secco GB, Fardelli R, Campora E, Lapertosa G, Gentile R, Zoli S and Prior C: Primary mucinous adenocarcinomas and signet-ring cell carcinomas of colon and rectum. Oncology. 51:30–34. 1994.PubMed/NCBI View Article : Google Scholar

26 

Belli S, Aytac HO, Karagulle E, Yabanoglu H, Kayaselcuk F and Yildirim S: Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature. Int Surg. 99:691–698. 2014.PubMed/NCBI View Article : Google Scholar

27 

Nitsche U, Zimmermann A, Spath C, Müller T, Maak M, Schuster T, Slotta-Huspenina J, Käser SA, Michalski CW, Janssen KP, et al: Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg. 258:775–783. 2013.PubMed/NCBI View Article : Google Scholar

28 

Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID and de Wilt JH: Colorectal signet-ring cell carcinoma: Benefit from adjuvant chemotherapy but a poor prognostic factor. Int J Cancer. 136:333–339. 2015.PubMed/NCBI View Article : Google Scholar

29 

Kim D, Kim SY, Lee JS, Hong YS, Kim JE, Kim KP, Kim J, Jang SJ, Yoon YK and Kim TW: Primary tumor location predicts poor clinical outcome with cetuximab in RAS wild-type metastatic colorectal cancer. BMC Gastroenterol. 17(121)2017.PubMed/NCBI View Article : Google Scholar

30 

Tung YS, Wu SC and Chen CP: Primary signet ring cell carcinoma of colorectum: An age- and sex-matched controlled study. Am J Gastroenterol. 91:2195–2199. 1996.PubMed/NCBI

31 

He J, Shin H, Wei X, Kadegowda AK, Chen R and Xie SK: NPC1L1 knockout protects against colitis-associated tumorigenesis in mice. BMC Cancer. 15(189)2015.PubMed/NCBI View Article : Google Scholar

32 

Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, et al: GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Elife. 8(e47178)2019.PubMed/NCBI View Article : Google Scholar

33 

Yang DA, Fan F, Camp ER, van Buren G, Liu W, Somcio R, Gray MJ, Cheng H, Hoff PM and Ellis LM: Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res. 12:4147–4153. 2006.PubMed/NCBI View Article : Google Scholar

34 

Hwang WL, Yang MH, Tsai ML, Lan HY, Su SH, Chang SC, Teng HW, Yang SH, Lan YT, Chiou SH and Wang HW: SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology. 141:279–291, 291.e1-e5. 2011.PubMed/NCBI View Article : Google Scholar

35 

Gasiulė S, Dreize N, Kaupinis A, Ražanskas R, Čiupas L, Stankevičius V, Kapustina Ž, Laurinavičius A, Valius M and Vilkaitis G: Molecular insights into miRNA-driven resistance to 5-fluorouracil and oxaliplatin chemotherapy: miR-23b modulates the epithelial-mesenchymal transition of colorectal cancer cells. J Clin Med Res. 8(2115)2019.PubMed/NCBI View Article : Google Scholar

36 

Bhangu A, Wood G, Mirnezami A, Darzi A, Tekkis P and Goldin R: Epithelial mesenchymal transition in colorectal cancer: Seminal role in promoting disease progression and resistance to neoadjuvant therapy. Surg Oncol. 21:316–323. 2012.PubMed/NCBI View Article : Google Scholar

37 

Sun L, Ke J, He Z, Chen Z, Huang Q, Ai W, Wang G, Wei Y, Zou X, Zhang S, et al: HES1 promotes colorectal cancer cell resistance To 5-Fu by inducing Of EMT and ABC transporter proteins. J Cancer. 8:2802–2808. 2017.PubMed/NCBI View Article : Google Scholar

38 

Fujikawa H, Tanaka K, Toiyama Y, Saigusa S, Inoue Y, Uchida K and Kusunoki M: High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells. J Gastroenterol. 47:775–784. 2012.PubMed/NCBI View Article : Google Scholar

39 

Ogino S, Brahmandam M, Cantor M, Namgyal C, Kawasaki T, Kirkner G, Meyerhardt JA, Loda M and Fuchs CS: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. Mod Pathol. 19:59–68. 2006.PubMed/NCBI View Article : Google Scholar

40 

Kakar S, Deng G, Smyrk CT, Cun L, Sahai V and Kim SY: Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma. Mod Pathol. 25:1040–1047. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tajiri K, Sudo T, Ishi K, Kawahara A, Nagasu S, Shimomura S, Yuge K, Katagiri M, Yomoda T, Fujiyoshi K, Fujiyoshi K, et al: Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification. Mol Clin Oncol 14: 98, 2021.
APA
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S. ... Akagi, Y. (2021). Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification. Molecular and Clinical Oncology, 14, 98. https://doi.org/10.3892/mco.2021.2260
MLA
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S., Yuge, K., Katagiri, M., Yomoda, T., Fujiyoshi, K., Kenichi, K., Ohchi, T., Yoshida, T., Mizobe, T., Fujita, F., Akiba, J., Akagi, Y."Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification". Molecular and Clinical Oncology 14.5 (2021): 98.
Chicago
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S., Yuge, K., Katagiri, M., Yomoda, T., Fujiyoshi, K., Kenichi, K., Ohchi, T., Yoshida, T., Mizobe, T., Fujita, F., Akiba, J., Akagi, Y."Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification". Molecular and Clinical Oncology 14, no. 5 (2021): 98. https://doi.org/10.3892/mco.2021.2260
Copy and paste a formatted citation
x
Spandidos Publications style
Tajiri K, Sudo T, Ishi K, Kawahara A, Nagasu S, Shimomura S, Yuge K, Katagiri M, Yomoda T, Fujiyoshi K, Fujiyoshi K, et al: Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification. Mol Clin Oncol 14: 98, 2021.
APA
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S. ... Akagi, Y. (2021). Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification. Molecular and Clinical Oncology, 14, 98. https://doi.org/10.3892/mco.2021.2260
MLA
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S., Yuge, K., Katagiri, M., Yomoda, T., Fujiyoshi, K., Kenichi, K., Ohchi, T., Yoshida, T., Mizobe, T., Fujita, F., Akiba, J., Akagi, Y."Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification". Molecular and Clinical Oncology 14.5 (2021): 98.
Chicago
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S., Yuge, K., Katagiri, M., Yomoda, T., Fujiyoshi, K., Kenichi, K., Ohchi, T., Yoshida, T., Mizobe, T., Fujita, F., Akiba, J., Akagi, Y."Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification". Molecular and Clinical Oncology 14, no. 5 (2021): 98. https://doi.org/10.3892/mco.2021.2260
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team