Open Access

Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification

  • Authors:
    • Kensuke Tajiri
    • Tomoya Sudo
    • Kazuo Ishi
    • Akihiko Kawahara
    • Sachiko Nagasu
    • Susumu Shimomura
    • Kotaro Yuge
    • Mitsuhiro Katagiri
    • Takato Yomoda
    • Kenji Fujiyoshi
    • Koshi Kenichi
    • Takafumi Ohchi
    • Takefumi Yoshida
    • Tomoaki Mizobe
    • Fumihiko Fujita
    • Jun Akiba
    • Yoshito Akagi
  • View Affiliations

  • Published online on: March 12, 2021     https://doi.org/10.3892/mco.2021.2260
  • Article Number: 98
  • Copyright: © Tajiri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Signet ring cell carcinoma (SRCC) is a rare pathological type of colorectal cancer, of which the clinicopathological features and genetic background have not yet been fully investigated. Previous research has focused on the optimization of colorectal cancer treatment utilizing consensus molecular subtyping (CMS). However, it is not known what type of CMS would be designated to SRCC treatment. In the current study, of 1,350 patients diagnosed with colorectal cancer who underwent surgery, 14 were diagnosed with SRCC. The case‑control cohort that fit the clinical background of the SRCC case was constructed. Statistical comparison between the SRCC group and the case‑control cohort was performed among clinicopathological variables. SRCC and well to moderately adenocarcinoma case mRNA were submitted to microarray analysis and CMS analysis. Compared with the case‑control cohort, the SRCC group was located more in the right‑sided colon, the lymphatic invasion was more severe and the peritoneal dissemination was more frequent. The cancer‑specific survival and the progression‑free survival were significantly worse in the SRCC group compared with the case‑control cohort. Microarray and CMS analysis identified that one SRCC case was significantly well assigned in the CMS 4 group and the other case was assigned in the CMS 1 group. Gene set analysis revealed the upregulation of EMT related genes and the downregulation of fatty acid, glycolysis, differentiation, MYC, HNF4A, DNA repair genes. In conclusion, the clinical characteristics of SRCC are severe but there is a possibility of the presence of different phenotypes according to CMS analysis.
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May-2021
Volume 14 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Tajiri K, Sudo T, Ishi K, Kawahara A, Nagasu S, Shimomura S, Yuge K, Katagiri M, Yomoda T, Fujiyoshi K, Fujiyoshi K, et al: Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification. Mol Clin Oncol 14: 98, 2021
APA
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S. ... Akagi, Y. (2021). Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification. Molecular and Clinical Oncology, 14, 98. https://doi.org/10.3892/mco.2021.2260
MLA
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S., Yuge, K., Katagiri, M., Yomoda, T., Fujiyoshi, K., Kenichi, K., Ohchi, T., Yoshida, T., Mizobe, T., Fujita, F., Akiba, J., Akagi, Y."Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification". Molecular and Clinical Oncology 14.5 (2021): 98.
Chicago
Tajiri, K., Sudo, T., Ishi, K., Kawahara, A., Nagasu, S., Shimomura, S., Yuge, K., Katagiri, M., Yomoda, T., Fujiyoshi, K., Kenichi, K., Ohchi, T., Yoshida, T., Mizobe, T., Fujita, F., Akiba, J., Akagi, Y."Investigation of clinicopathological characters and gene expression features in colorectal signet‑ring cell carcinoma utilizing CMS classification". Molecular and Clinical Oncology 14, no. 5 (2021): 98. https://doi.org/10.3892/mco.2021.2260