Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2021 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report

  • Authors:
    • Shuichi Fukuda
    • Kaoru Okajima
    • Kaoru Okada
    • Kohei Fukuda
    • Tomoko Wakasa
    • Tomoyuki Tsujimoto
    • Atsushi Gakuhara
    • Hideo Tomihara
    • Katsuya Ohta
    • Kotaro Kitani
    • Kazuhiko Hashimoto
    • Hajime Ishikawa
    • Jin-Ichi Hida
    • Masao Yukawa
    • Yoshio Ohta
    • Masatoshi Inoue
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Kindai University Nara Hospital, Ikoma, Nara 630‑0293, Japan, Department of Radiology, Kindai University Nara Hospital, Ikoma, Nara 630‑0293, Japan, Department of Pathology, Kindai University Nara Hospital, Ikoma, Nara 630‑0293, Japan
    Copyright: © Fukuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 130
    |
    Published online on: May 7, 2021
       https://doi.org/10.3892/mco.2021.2292
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Treatment strategies for distant organ metastasis have changed markedly since the concept of oligometastasis was introduced. The perception that distant organ metastasis is a systemic disease and not eligible for local therapy is now a thing of the past. Therefore, the present report details a case of postoperative solitary liver metastasis from esophageal squamous cell carcinoma (ESCC), which achieved a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil (5‑FU) followed by stereotactic body radiotherapy (SBRT). A 76‑year‑old male patient underwent esophagectomy for lower thoracic ESCC. At 7 months after surgery, abdominal CT revealed a solitary hypovascular mass, 28 mm in size, in segment 7 of the liver. After three courses of chemotherapy with cisplatin and 5‑FU, abdominal CT revealed that the liver mass had shrunk to 7 mm in size. SBRT was then administered with a 6 MV X‑ray beam generated by a linear accelerator. A total dose of 50 Gy was given in 5 fractions of 10 Gy to the liver mass. At 1 month after SBRT, abdominal CT revealed that the liver mass had disappeared. The patient received no further adjuvant chemotherapy and had no recurrence at 18 months after diagnosis of liver metastasis and 13 months after SBRT.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Watanabe M, Tachimori Y, Oyama T, Toh Y, Matsubara H, Ueno M, Kono K, Uno T, Ishihara R, Muro K, et al: Comprehensive registry of esophageal cancer in Japan, 2013. Esophagus. 18:1–24. 2021.PubMed/NCBI View Article : Google Scholar

2 

Kitagawa Y, Uno T, Oyama T, Kato K, Kato H, Kawakubo H, Kawamura O, Kusano M, Kuwano H, Takeuchi H, et al: Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: Part 2. Esophagus. 16:25–43. 2019.PubMed/NCBI View Article : Google Scholar

3 

Huddy JR, Thomas RL, Worthington TR and Karanjia ND: Liver metastases from esophageal carcinoma: Is there a role for surgical resection? Dis Esophagus. 28:483–487. 2015.PubMed/NCBI View Article : Google Scholar

4 

Miyata H, Yamasaki M, Kurokawa Y, Takiguchi S, Nakajima K, Fujiwara Y, Konishi K, Mori M and Doki Y: Survival factors in patients with recurrence after curative resection of esophageal squamous cell carcinomas. Ann Surg Oncol. 18:3353–3361. 2011.PubMed/NCBI View Article : Google Scholar

5 

Bleiberg H, Conroy T, Paillot B, Lacave AJ, Blijham G, Jacob JH, Bedenne L, Namer M, De Besi P, Gay F, et al: Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesopahgeal cancer. Eur J Cancer. 33:1216–1220. 1997.PubMed/NCBI View Article : Google Scholar

6 

Iizuka T, Kakegawa T, Ide H, Ando N, Watanabe H, Tanaka O, Takagi I, Isono K, Ishida K, Arimori M, et al: Phase II evaluation of cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the esophagus: A Japanese esophageal oncology group trial. Jpn J Clin Oncol. 22:172–176. 1992.PubMed/NCBI

7 

Hellman S and Weichselbaum RR: Oligometastases. J Clin Oncol. 13:8–10. 1995.PubMed/NCBI View Article : Google Scholar

8 

Jamel S, Tukanova K and Markar S: Detection and management of oligometastatic disease in oesophageal cancer and identification of prognostic factors: A systematic review. World J Gastrointest Oncol. 11:741–749. 2019.PubMed/NCBI View Article : Google Scholar

9 

Li J, Wen Y, Xiang Z, Du H, Geng L, Yang X, Zhang Y, Bai J, Dai T, Feng G, et al: Radical radiotherapy for metachronous oligometastasis after initial treatment of esophageal cancer. Radiother Oncol. 154:201–206. 2021.PubMed/NCBI View Article : Google Scholar

10 

Ohkura Y, Shindoh J, Ueno M, Iizuka T and Udagawa H: Clinicopathologic characteristics of oligometastases from esophageal cancer and long-term outcomes of resection. Ann Surg Oncol. 27:651–659. 2020.PubMed/NCBI View Article : Google Scholar

11 

Baba Y, Watanabe M, Kawanaka K, Iwagami S, Ishimoto T, Iwatsuki M, Yoshida N, Yamashita Y and Baba H: Radiofrequency ablation for pulmonary metastases from esophageal squamous cell carcinoma. Dis Esophagus. 27:36–41. 2014.PubMed/NCBI View Article : Google Scholar

12 

Dawood O, Mahadevan A and Goodman KA: Stereotactic body radiation therapy for liver metastases. Eur J Cancer. 45:2947–2959. 2009.PubMed/NCBI View Article : Google Scholar

13 

Lehrer EJ, Singh R, Wang M, Chinchilli VM, Trifiletti DM, Ost P, Siva S, Meng MB, Tchelebi L and Zaorsky NG: Safety and survival rates associated with ablative stereotactic radiotherapy for patients with oligometastatic cancer: A systematic review and meta-analysis. JAMA Oncol. 7:92–106. 2021.PubMed/NCBI View Article : Google Scholar

14 

Palma DA, Olson R, Harrow S, Gaede S, Louie AV, Haasbeek C, Mulroy L, Lock M, Rodrigues GB, Yaremko BP, et al: Stereotactic ablative radiotherapy for the comprehensive treatment of oligometastatic cancers: Long-term results of the SABR-COMET phase II randomized trial. J Clin Oncol. 38:2830–2838. 2020.PubMed/NCBI View Article : Google Scholar

15 

Pennathur A, Gibson MK, Jobe BA and Luketich JD: Oesophageal carcinoma. Lancet. 381:400–412. 2013.PubMed/NCBI View Article : Google Scholar

16 

Palma DA, Salama JK, Lo SS, Senan S, Treasure T, Govindan R and Weichselbaum R: The oligometastatic state - separating truth from wishful thinking. Nat Rev Clin Oncol. 11:549–557. 2014.PubMed/NCBI View Article : Google Scholar

17 

Morinaga T, Iwatsuki M, Yamashita K, Harada K, Kurashige J, Nagai Y, Iwagami S, Baba Y, Yoshida N and Baba H: Oligometastatic recurrence as a prognostic factor after curative resection of esophageal squamous cell carcinoma. Surg Today. 51:798–806. 2021.PubMed/NCBI View Article : Google Scholar

18 

Rusthoven KE, Kavanagh BD, Cardenes H, Stieber VW, Burri SH, Feigenberg SJ, Chidel MA, Pugh TJ, Franklin W, Kane M, et al: Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol. 27:1572–1578. 2009.PubMed/NCBI View Article : Google Scholar

19 

Guckenberger M, Lievens Y, Bouma AB, Collette L, Dekker A, deSouza NM, Dingemans AC, Fournier B, Hurkmans C, Lecouvet FE, et al: Characterisation and classification of oligometastatic disease: A European society for radiotherapy and oncology and European organisation for research and treatment of cancer consensus recommendation. Lancet Oncol. 21:e18–e28. 2020.PubMed/NCBI View Article : Google Scholar

20 

Ghaly G, Harrison S, Kamel MK, Rahouma M, Nasar A, Port JL, Stiles BM and Altorki NK: Predictors of survival after treatment of oligometastases after esophagectomy. Ann Thorac Surg. 105:357–362. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fukuda S, Okajima K, Okada K, Fukuda K, Wakasa T, Tsujimoto T, Gakuhara A, Tomihara H, Ohta K, Kitani K, Kitani K, et al: Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report. Mol Clin Oncol 15: 130, 2021.
APA
Fukuda, S., Okajima, K., Okada, K., Fukuda, K., Wakasa, T., Tsujimoto, T. ... Inoue, M. (2021). Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report. Molecular and Clinical Oncology, 15, 130. https://doi.org/10.3892/mco.2021.2292
MLA
Fukuda, S., Okajima, K., Okada, K., Fukuda, K., Wakasa, T., Tsujimoto, T., Gakuhara, A., Tomihara, H., Ohta, K., Kitani, K., Hashimoto, K., Ishikawa, H., Hida, J., Yukawa, M., Ohta, Y., Inoue, M."Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report". Molecular and Clinical Oncology 15.1 (2021): 130.
Chicago
Fukuda, S., Okajima, K., Okada, K., Fukuda, K., Wakasa, T., Tsujimoto, T., Gakuhara, A., Tomihara, H., Ohta, K., Kitani, K., Hashimoto, K., Ishikawa, H., Hida, J., Yukawa, M., Ohta, Y., Inoue, M."Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report". Molecular and Clinical Oncology 15, no. 1 (2021): 130. https://doi.org/10.3892/mco.2021.2292
Copy and paste a formatted citation
x
Spandidos Publications style
Fukuda S, Okajima K, Okada K, Fukuda K, Wakasa T, Tsujimoto T, Gakuhara A, Tomihara H, Ohta K, Kitani K, Kitani K, et al: Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report. Mol Clin Oncol 15: 130, 2021.
APA
Fukuda, S., Okajima, K., Okada, K., Fukuda, K., Wakasa, T., Tsujimoto, T. ... Inoue, M. (2021). Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report. Molecular and Clinical Oncology, 15, 130. https://doi.org/10.3892/mco.2021.2292
MLA
Fukuda, S., Okajima, K., Okada, K., Fukuda, K., Wakasa, T., Tsujimoto, T., Gakuhara, A., Tomihara, H., Ohta, K., Kitani, K., Hashimoto, K., Ishikawa, H., Hida, J., Yukawa, M., Ohta, Y., Inoue, M."Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report". Molecular and Clinical Oncology 15.1 (2021): 130.
Chicago
Fukuda, S., Okajima, K., Okada, K., Fukuda, K., Wakasa, T., Tsujimoto, T., Gakuhara, A., Tomihara, H., Ohta, K., Kitani, K., Hashimoto, K., Ishikawa, H., Hida, J., Yukawa, M., Ohta, Y., Inoue, M."Postoperative solitary liver metastasis from esophageal squamous cell carcinoma achieving a clinical complete response to chemotherapy with cisplatin and 5‑fluorouracil followed by stereotactic body radiotherapy: A case report". Molecular and Clinical Oncology 15, no. 1 (2021): 130. https://doi.org/10.3892/mco.2021.2292
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team