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Intracranial non‑myxoid angiomatoid fibrous histiocytoma with EWSR1‑CREB1 transcript fusion treated with doxorubicin: A case report

  • Authors:
    • Louis Garnier
    • Tanguy Fenouil
    • Daniel Pissaloux
    • Roxana Ameli
    • François Ducray
    • David Meyronet
    • Jerome Honnorat
  • View Affiliations / Copyright

    Affiliations: Department of Neuro‑Oncology, East Group Hospital, Hospices Civils de Lyon, 69677 Lyon, France, Department of Pathology, East Group Hospital, Hospices Civils de Lyon, 69677 Lyon, France, Department of Clinical Sciences, Claude Bernard Lyon 1 University, INSERM U1052, CNRS UMR5286, Léon Bérard Center, Cancer Research Center of Lyon, 69677 Lyon, France, Department of Neuro‑Radiology, East Group Hospital, Hospices Civils de Lyon, 69677 Lyon, France, Department of Clinical Sciences, Claude Bernard Lyon 1 University, 69008 Lyon, France
    Copyright: © Garnier et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 131
    |
    Published online on: May 9, 2021
       https://doi.org/10.3892/mco.2021.2293
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Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that has only been reported in the central nervous system in case reports. After surgery, patients exhibit tumor recurrence. Pathological diagnosis of AHF remains difficult, especially in sites other than skin. AFH can harbor characteristic translocations implying that the Ewing sarcoma breakpoint region 1 gene (EWSR1) fuses with the transcription factor cyclic AMP response element binding (CREB) family genes. Doxorubicin is a chemotherapy that has previously been used successfully in two metastatic soft tissue AFH cases but never in intracranial AFH. The present report describes a case of an adult with a progressive classical intracranial non‑myxoid AFH with ESWR1‑CREB1 transcript fusion 4 years after surgery. The patient was treated with doxorubicin as a single agent chemotherapy. This treatment resulted in a prolonged stable disease 15 months after treatment discontinuation. This is the first reported case of a treatment with doxorubicin in an adult with progressive intracranial AFH with ESWR1‑CREB1 transcript fusion which was sustained after treatment discontinuation.
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1 

Lemaigre FP, Ace CI and Green MR: The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators. Nucleic Acids Res. 21:2907–2911. 1993.PubMed/NCBI View Article : Google Scholar

2 

Gonzalez GA and Montminy MR: Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 59:675–680. 1989.PubMed/NCBI View Article : Google Scholar

3 

Thway K and Fisher C: Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: The current status. Am J Surg Pathol. 36(11)2012.PubMed/NCBI View Article : Google Scholar

4 

Enzinger FM: Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer. 44:2147–2157. 1979.PubMed/NCBI View Article : Google Scholar

5 

Antonescu CR and Rossi S: WHO Classification of Tumours of Soft Tissue and Bone. Vol 5. 4th edition. Fletcher CD, Bridge JA, Hogendoorn PC and Mertens F (eds). IARC, Lyon, pp204-205, 2013.

6 

Saito K, Kobayashi E, Yoshida A, Araki Y, Kubota D, Tanzawa Y, Kawai A, Yanagawa T, Takagishi K and Chuman H: Angiomatoid fibrous histiocytoma: A series of seven cases including genetically confirmed aggressive cases and a literature review. BMC Musculoskelet Disord. 18(31)2017.PubMed/NCBI View Article : Google Scholar

7 

Fanburg-Smith JC and Miettinen M: Angiomatoid ‘malignant’ fibrous histiocytoma: A clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol. 30:1336–1343. 1999.PubMed/NCBI View Article : Google Scholar

8 

Huret JL: EWSR1 (Ewing sarcoma breakpoint region 1). Atlas Genet Cytogenet Oncol Haematol. 15:395–407. 2011.

9 

Dunham C, Hussong J, Seiff M, Pfeifer J and Perry A: Primary Intracerebral angiomatoid fibrous histiocytoma: Report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes. Am J Surg Pathol. 32:478–484. 2008.PubMed/NCBI View Article : Google Scholar

10 

Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB and Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg. 112:978–982. 2010.PubMed/NCBI View Article : Google Scholar

11 

Hansen JM, Larsen VA, Scheie D, Perry A and Skjøth-Rasmussen J: Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features. Cephalalgia. 35:1334–1336. 2015.PubMed/NCBI View Article : Google Scholar

12 

Alshareef MA, Almadidy Z, Baker T, Perry A, Welsh CT and Vandergrift WA III: Intracranial angiomatoid fibrous histiocytoma: Case report and literature review. World Neurosurg. 96:403–409. 2016.PubMed/NCBI View Article : Google Scholar

13 

Konstantinidis A, Cheesman E, O'Sullivan J, Pavaine J, Avula S, Pizer B and Kilday JP: Intracranial angiomatoid fibrous histiocytoma with EWSR1-CREB family fusions: A report of 2 pediatric cases. World Neurosurg. 126:113–119. 2019.PubMed/NCBI View Article : Google Scholar

14 

Kao YC, Sung YS, Zhang L, Chen CL, Vaiyapuri S, Rosenblum MK and Antonescu CR: EWSR1 fusions with CREB family transcription factors define a novel myxoid mesenchymal tumor with predilection for intracranial location. Am J Surg Pathol. 41:482–490. 2017.PubMed/NCBI View Article : Google Scholar

15 

Gareton A, Pierron G, Mokhtari K, Tran S, Tauziède-Espariat A, Pallud J, Louvel G, Meary E, Capelle L, Chrétien F and Varlet P: ESWR1-CREM fusion in an intracranial myxoid angiomatoid fibrous histiocytoma-like tumor: A case report and literature review. J Neuropathol Exp Neurol. 77:537–541. 2018.PubMed/NCBI View Article : Google Scholar

16 

Sciot R, Jacobs S, Calenbergh FV, Demaerel P, Wozniak A and Debiec-Rychter M: Primary myxoid mesenchymal tumour with intracranial location: Report of a case with a EWSR1-ATF1 fusion. Histopathology. 72:880–883. 2018.PubMed/NCBI View Article : Google Scholar

17 

Bale TA, Oviedo A, Kozakewich H, Giannini C, Davineni PK, Ligon K and Alexandrescu S: Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: Myxoid variant of angiomatoid fibrous histiocytoma or novel entity? Brain Pathol. 28:183–191. 2018.PubMed/NCBI View Article : Google Scholar

18 

Ghanbari N, Lam A, Wycoco V and Lee G: Intracranial myxoid variant of angiomatoid fibrous histiocytoma: A case report and literature review. Cureus. 11(e4261)2019.PubMed/NCBI View Article : Google Scholar

19 

Gunness VR, Munoz I, González-López P, Alshafai N, Mikalkova A and Spears J: Intracranial angiomatoid fibrous histiocytoma with Hodgkin lymphoma. Med J Malaysia. 74:234–236. 2019.PubMed/NCBI

20 

White MD, McDowell MM, Pearce TM, Bukowinski AJ and Greene S: Intracranial Myxoid mesenchymal tumor with rare EWSR1-CREM translocation. Pediatr Neurosurg. 54:347–353. 2019.PubMed/NCBI View Article : Google Scholar

21 

Ballester LY, Meis JM, Lazar AJ, Prabhu SS, Hoang KB, Leeds NE and Fuller GN: Intracranial myxoid mesenchymal tumor with EWSR1-ATF1 Fusion. J Neuropathol Exp Neurol. 79:347–351. 2020.PubMed/NCBI View Article : Google Scholar

22 

Komatsu M, Yoshida A, Tanaka K, Matsuo K, Sasayama T, Kojita Y, Kanda T, Kodama Y, Itoh T and Hirose T: Intracranial myxoid mesenchymal tumor with EWSR1-CREB1 gene fusion: A case report and literature review. Brain Tumor Pathol. 37:76–80. 2020.PubMed/NCBI View Article : Google Scholar

23 

Spatz M, Nussbaum ES, Lyons L, Greenberg S, Kallmes KM and Nussbaum LA: Primary intracranial angiomatoid fibrous histiocytoma: A case report and literature review. Br J Neurosurg: Mar 15, 2018 (Epub ahead of print). doi: 10.1080/02688697.2018.1451823.

24 

Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD and Ladanyi M: EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 46:1051–1060. 2007.PubMed/NCBI View Article : Google Scholar

25 

Thway K and Fisher C: Angiomatoid fibrous histiocytoma: The current status of pathology and genetics. Arch Pathol Lab Med. 139:674–682. 2015.PubMed/NCBI View Article : Google Scholar

26 

Ogden S, Harave S, McPartland J, Brennan B, Jeys L, Losty P and Pizer B: Angiomatoid fibrous histiocytoma: A case of local recurrence and metastases to loco-regional lymph nodes that responded to chemotherapy. Pediatr Blood Cancer: 64, 2017 doi: 10.1002/pbc.26376.

27 

Bernini JC, Fort DW, Pritchard M, Rogers BB and Winick NJ: Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma. Cancer. 74:962–964. 1994.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Garnier L, Fenouil T, Pissaloux D, Ameli R, Ducray F, Meyronet D and Honnorat J: Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report. Mol Clin Oncol 15: 131, 2021.
APA
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., & Honnorat, J. (2021). Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report. Molecular and Clinical Oncology, 15, 131. https://doi.org/10.3892/mco.2021.2293
MLA
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., Honnorat, J."Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report". Molecular and Clinical Oncology 15.1 (2021): 131.
Chicago
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., Honnorat, J."Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report". Molecular and Clinical Oncology 15, no. 1 (2021): 131. https://doi.org/10.3892/mco.2021.2293
Copy and paste a formatted citation
x
Spandidos Publications style
Garnier L, Fenouil T, Pissaloux D, Ameli R, Ducray F, Meyronet D and Honnorat J: Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report. Mol Clin Oncol 15: 131, 2021.
APA
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., & Honnorat, J. (2021). Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report. Molecular and Clinical Oncology, 15, 131. https://doi.org/10.3892/mco.2021.2293
MLA
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., Honnorat, J."Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report". Molecular and Clinical Oncology 15.1 (2021): 131.
Chicago
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., Honnorat, J."Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report". Molecular and Clinical Oncology 15, no. 1 (2021): 131. https://doi.org/10.3892/mco.2021.2293
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