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Intracranial non‑myxoid angiomatoid fibrous histiocytoma with EWSR1‑CREB1 transcript fusion treated with doxorubicin: A case report

  • Authors:
    • Louis Garnier
    • Tanguy Fenouil
    • Daniel Pissaloux
    • Roxana Ameli
    • François Ducray
    • David Meyronet
    • Jerome Honnorat
  • View Affiliations

  • Published online on: May 9, 2021     https://doi.org/10.3892/mco.2021.2293
  • Article Number: 131
  • Copyright: © Garnier et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that has only been reported in the central nervous system in case reports. After surgery, patients exhibit tumor recurrence. Pathological diagnosis of AHF remains difficult, especially in sites other than skin. AFH can harbor characteristic translocations implying that the Ewing sarcoma breakpoint region 1 gene (EWSR1) fuses with the transcription factor cyclic AMP response element binding (CREB) family genes. Doxorubicin is a chemotherapy that has previously been used successfully in two metastatic soft tissue AFH cases but never in intracranial AFH. The present report describes a case of an adult with a progressive classical intracranial non‑myxoid AFH with ESWR1‑CREB1 transcript fusion 4 years after surgery. The patient was treated with doxorubicin as a single agent chemotherapy. This treatment resulted in a prolonged stable disease 15 months after treatment discontinuation. This is the first reported case of a treatment with doxorubicin in an adult with progressive intracranial AFH with ESWR1‑CREB1 transcript fusion which was sustained after treatment discontinuation.
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July-2021
Volume 15 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Garnier L, Fenouil T, Pissaloux D, Ameli R, Ducray F, Meyronet D and Honnorat J: Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report. Mol Clin Oncol 15: 131, 2021.
APA
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., & Honnorat, J. (2021). Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report. Molecular and Clinical Oncology, 15, 131. https://doi.org/10.3892/mco.2021.2293
MLA
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., Honnorat, J."Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report". Molecular and Clinical Oncology 15.1 (2021): 131.
Chicago
Garnier, L., Fenouil, T., Pissaloux, D., Ameli, R., Ducray, F., Meyronet, D., Honnorat, J."Intracranial non‑myxoid angiomatoid fibrous histiocytoma with <em>EWSR1‑CREB1</em> transcript fusion treated with doxorubicin: A case report". Molecular and Clinical Oncology 15, no. 1 (2021): 131. https://doi.org/10.3892/mco.2021.2293