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Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review

  • Authors:
    • Silvia Bisello
    • Anna Chiara Camilletti
    • Federica Bertini
    • Milly Buwenge
    • Alessandra Arcelli
    • Gabriella Macchia
    • Francesco Deodato
    • Savino Cilla
    • Giancarlo Mattiucci
    • Rosa Autorino
    • Giovanni Brandi
    • Lidia Strigari
    • Silvia Cammelli
    • Alessio G. Morganti
  • View Affiliations / Copyright

    Affiliations: Radiation Oncology, IRCCS Azienda Ospedaliero‑Universitaria di Bologna, I‑40138 Bologna, Italy, Radiotherapy Unit, Gemelli Molise Hospital, Università Cattolica del Sacro Cuore, I-86100 Campobasso, Italy, Medical Physic Unit, Gemelli Molise Hospital, Università Cattolica del Sacro Cuore, I-86100 Campobasso, Italy, Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radioterapia, Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, I-00168 Rome, Italy, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola‑Malpighi Hospital, I-40138 Bologna, Italy, Medical Physics, IRCCS Azienda Ospedaliero‑Universitaria di Bologna, I-40138 Bologna, Italy
    Copyright: © Bisello et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 152
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    Published online on: June 3, 2021
       https://doi.org/10.3892/mco.2021.2314
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Abstract

Among biliary tract cancers, intrahepatic cholangiocarcinoma (ICC) has different characteristics compared with those in other sites. Current guidelines suggest several treatment options for ICC, including stereotactic body radiation therapy (SBRT). However, the role of SBRT in locally advanced ICC is unclear. The aim of the present study was to present a systematic review on the efficacy and safety of SBRT in ICC. A systematic review based on the PRISMA methodology was performed. Only papers reporting outcomes in terms of overall survival (OS) after SBRT in inoperable patients with ICC were included. Secondary aims were local control (LC), progression‑free survival (PFS) and treatment‑related toxicity. Six papers (145 patients) were included in the present analysis. SBRT was frequently used as a salvage treatment, since 28.6‑66.7% of patients received previous systemic or local treatments. The median SBRT dose was 45 Gy delivered in 3‑5 fractions. The median follow‑up was 16 months, and median OS time was 14 months (range, 10‑48 months). In one of the included studies, SBRT was significantly superior in terms of OS compared with both chemoradiation and trans‑arterial‑radio‑embolization. The 1‑year LC rate was 85% in one study, and 1‑year PFS rates were 50 and 68% in two studies, respectively. Toxicity was generally not reported in detail or was reported including other sites of biliary cancers. Overall, limited evidence was available on the efficacy of SBRT in ICC, which should be further investigated in prospective studies with a larger number of patients. However, based on the available data, SBRT seems to produce similar results compared with other ICC treatments, with the advantage of being a very short and non‑invasive therapy. Therefore, SBRT should be considered in selected patients with ICC.
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Copy and paste a formatted citation
Spandidos Publications style
Bisello S, Camilletti AC, Bertini F, Buwenge M, Arcelli A, Macchia G, Deodato F, Cilla S, Mattiucci G, Autorino R, Autorino R, et al: Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review. Mol Clin Oncol 15: 152, 2021.
APA
Bisello, S., Camilletti, A.C., Bertini, F., Buwenge, M., Arcelli, A., Macchia, G. ... Morganti, A.G. (2021). Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review. Molecular and Clinical Oncology, 15, 152. https://doi.org/10.3892/mco.2021.2314
MLA
Bisello, S., Camilletti, A. C., Bertini, F., Buwenge, M., Arcelli, A., Macchia, G., Deodato, F., Cilla, S., Mattiucci, G., Autorino, R., Brandi, G., Strigari, L., Cammelli, S., Morganti, A. G."Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review". Molecular and Clinical Oncology 15.2 (2021): 152.
Chicago
Bisello, S., Camilletti, A. C., Bertini, F., Buwenge, M., Arcelli, A., Macchia, G., Deodato, F., Cilla, S., Mattiucci, G., Autorino, R., Brandi, G., Strigari, L., Cammelli, S., Morganti, A. G."Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review". Molecular and Clinical Oncology 15, no. 2 (2021): 152. https://doi.org/10.3892/mco.2021.2314
Copy and paste a formatted citation
x
Spandidos Publications style
Bisello S, Camilletti AC, Bertini F, Buwenge M, Arcelli A, Macchia G, Deodato F, Cilla S, Mattiucci G, Autorino R, Autorino R, et al: Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review. Mol Clin Oncol 15: 152, 2021.
APA
Bisello, S., Camilletti, A.C., Bertini, F., Buwenge, M., Arcelli, A., Macchia, G. ... Morganti, A.G. (2021). Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review. Molecular and Clinical Oncology, 15, 152. https://doi.org/10.3892/mco.2021.2314
MLA
Bisello, S., Camilletti, A. C., Bertini, F., Buwenge, M., Arcelli, A., Macchia, G., Deodato, F., Cilla, S., Mattiucci, G., Autorino, R., Brandi, G., Strigari, L., Cammelli, S., Morganti, A. G."Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review". Molecular and Clinical Oncology 15.2 (2021): 152.
Chicago
Bisello, S., Camilletti, A. C., Bertini, F., Buwenge, M., Arcelli, A., Macchia, G., Deodato, F., Cilla, S., Mattiucci, G., Autorino, R., Brandi, G., Strigari, L., Cammelli, S., Morganti, A. G."Stereotactic radiotherapy in intrahepatic cholangiocarcinoma: A systematic review". Molecular and Clinical Oncology 15, no. 2 (2021): 152. https://doi.org/10.3892/mco.2021.2314
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