Anaplastic thyroid cancer with long‑term survival with lenvatinib therapy and preservation of laryngeal function after one‑stage reconstruction: A case report

Tanaka,Akihisa; Uemura,Hirokazu; Masui,Takashi; Kanazawa,Shigenori; Yoshii,Yumi; Kanno,Masatoshi; Morita,Gohei; Obayashi,Chiho; Yamanaka,Toshiaki; Kitahara,Tadashi

doi:10.3892/mco.2021.2320

Anaplastic thyroid cancer with long‑term survival with lenvatinib therapy and preservation of laryngeal function after one‑stage reconstruction: A case report

Authors:
- Akihisa Tanaka
- Hirokazu Uemura
- Takashi Masui
- Shigenori Kanazawa
- Yumi Yoshii
- Masatoshi Kanno
- Gohei Morita
- Chiho Obayashi
- Toshiaki Yamanaka
- Tadashi Kitahara
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Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Otorhinolaryngology‑Head and Neck Surgery, Nippon Life Hospital, Osaka‑city, Osaka 550‑0006, Japan, Department of Cancer Genomics and Medical Oncology, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara 634‑8522, Japan
Published online on: June 11, 2021 https://doi.org/10.3892/mco.2021.2320
Article Number: 158
Copyright : © Tanaka et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Laryngotracheal reconstruction is performed to treat locally advanced thyroid carcinoma invading the larynx and/or trachea. The reconstructive technique varies. The present report describes the case of a 71‑year‑old female patient who underwent surgery for thyroid carcinoma involving the larynx. Reconstructive surgical techniques were employed to maintain laryngeal structure and function. An anterolateral thigh flap with free rib cartilage grafts was used to compensate for laryngeal defects. Although a temporary tracheal stoma was constructed, it closed spontaneously after decannulation. Therefore, one‑stage laryngeal reconstruction was accomplished. Post‑operative histopathological examination revealed focal anaplastic changes in the lesion, which mainly consisted of papillary components. Post‑operative positron emission tomography/computed tomography indicated early recurrence in the left side of the neck. Therefore, lenvatinib was started as adjuvant therapy. Complete response was observed with lenvatinib therapy. The patient was alive and had good laryngeal function 26 months after the operation. One‑stage laryngeal reconstruction can reduce burden and improve quality of life in patients with thyroid carcinoma involving the larynx. Lenvatinib may be useful for treating early recurrence of anaplastic thyroid carcinoma after reconstructive surgery with a free flap.

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